ID   ZN614_MACFA             Reviewed;         582 AA.
AC   Q95K49;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Zinc finger protein 614;
GN   Name=ZNF614; ORFNames=QtrA-10780;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB066544; BAB62218.1; -; mRNA.
DR   RefSeq; NP_001306571.1; NM_001319642.1.
DR   AlphaFoldDB; Q95K49; -.
DR   SMR; Q95K49; -.
DR   STRING; 9541.XP_005590226.1; -.
DR   GeneID; 102146022; -.
DR   CTD; 80110; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..582
FT                   /note="Zinc finger protein 614"
FT                   /id="PRO_0000234599"
FT   DOMAIN          8..79
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         202..224
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         254..278
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         284..306
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         396..418
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         424..446
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         452..474
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         480..502
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         508..530
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         536..558
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   582 AA;  66939 MW;  DBA59806614C88A6 CRC64;
     MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ TSKPDVLSKL
     AHGQEPWITV AKIQNKNCPG IGKADSLLQE HSLNQRLLKS VQQCNGQNTL RNTVHLSKTH
     FPIVQNHDTF DLYRKNLKSS LSLINQKRRH GINNPVEFIG GEKTLKHECM HAKTRFSENA
     KCIHTKFQVF KHQRTQKIEK PHACIECEQT FLRKSQLIYH ENIHIPENPG SGQCEKLSRS
     VLFTKHLKTN TRDKICIPNE YRKGSTVNSR LIAHQQTHTE EKSYMCSECG KGFTMKRYLI
     AHQRTHSGEK PYVCNECGKG FTVKSNLIVH QRTHTGEKPY ICSECGKGFT MKRYLVVHQR
     THTGEKPYIC SECGKGFTVK SNLIVHQRSH TGEKSYICSE CGKGFTVKRT LIIHQRTHTG
     EKSYICNECG KGFTTKRTLI IHQRTHTGEK PYECNECGKA FSQKICLIQH ERCHTGKTPF
     VCTECGKSYS HKYGLITHQR IHTGEKPYEC NECGKAFTTK SVLNVHQRTH TGERPYGCSD
     CEKAFSHLSN LVKHKKMHTR EMGRISQVEN SCNEESQLLP YK