CCA12_ARATH
ID CCA12_ARATH Reviewed; 442 AA.
AC Q9FVX0;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cyclin-A1-2;
DE AltName: Full=G2/mitotic-specific cyclin-A1-2;
DE Short=CycA1;2;
DE AltName: Full=Protein TARDY ASYNCHRONOUS MEIOSIS;
GN Name=CYCA1-2; Synonyms=TAM; OrderedLocusNames=At1g77390; ORFNames=F2P24.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF THR-283.
RX PubMed=15557098; DOI=10.1104/pp.104.051201;
RA Wang Y., Magnard J.-L., McCormick S., Yang M.;
RT "Progression through meiosis I and meiosis II in Arabidopsis anthers is
RT regulated by an A-type cyclin predominately expressed in prophase I.";
RL Plant Physiol. 136:4127-4135(2004).
RN [5]
RP DEVELOPMENTAL STAGE, AND INTERACTION WITH FZR1 AND FZR2.
RX PubMed=15970679;
RA Fueloep K., Tarayre S., Kelemen Z., Horvath G., Kevei Z., Nikovics K.,
RA Bako L., Brown S., Kondorosi A., Kondorosi E.;
RT "Arabidopsis anaphase-promoting complexes: multiple activators and wide
RT range of substrates might keep APC perpetually busy.";
RL Cell Cycle 4:1084-1092(2005).
RN [6]
RP INTERACTION WITH CDC20-1 AND CDC20-2.
RX PubMed=21687678; DOI=10.1371/journal.pone.0020618;
RA Kevei Z., Baloban M., Da Ines O., Tiricz H., Kroll A., Regulski K.,
RA Mergaert P., Kondorosi E.;
RT "Conserved CDC20 cell cycle functions are carried out by two of the five
RT isoforms in Arabidopsis thaliana.";
RL PLoS ONE 6:E20618-E20618(2011).
CC -!- FUNCTION: Involved in the regulation of male meiosis progression.
CC {ECO:0000269|PubMed:15557098}.
CC -!- SUBUNIT: Interacts with CDC20-1, CDC20-2, FZR2/CCS52A1 and
CC FZR1/CCS52A2. {ECO:0000269|PubMed:15970679,
CC ECO:0000269|PubMed:21687678}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15557098}. Nucleus
CC {ECO:0000269|PubMed:15557098}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems and flowers.
CC {ECO:0000269|PubMed:15557098}.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed at zygotene, highly at pachitene
CC and disappears from late diplotene to anaphase. Pronounced peak at the
CC G1/S boundary but does not show mitotic expression.
CC {ECO:0000269|PubMed:15557098, ECO:0000269|PubMed:15970679}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG29191.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC078898; AAG29191.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35972.1; -; Genomic_DNA.
DR PIR; A96803; A96803.
DR RefSeq; NP_177863.2; NM_106388.4.
DR AlphaFoldDB; Q9FVX0; -.
DR SMR; Q9FVX0; -.
DR BioGRID; 29294; 3.
DR STRING; 3702.AT1G77390.1; -.
DR PaxDb; Q9FVX0; -.
DR PRIDE; Q9FVX0; -.
DR EnsemblPlants; AT1G77390.1; AT1G77390.1; AT1G77390.
DR GeneID; 844075; -.
DR Gramene; AT1G77390.1; AT1G77390.1; AT1G77390.
DR KEGG; ath:AT1G77390; -.
DR Araport; AT1G77390; -.
DR TAIR; locus:2031407; AT1G77390.
DR eggNOG; KOG0654; Eukaryota.
DR HOGENOM; CLU_020695_13_2_1; -.
DR InParanoid; Q9FVX0; -.
DR OMA; MCFLRRF; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; Q9FVX0; -.
DR PRO; PR:Q9FVX0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FVX0; baseline and differential.
DR Genevisible; Q9FVX0; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:TAIR.
DR GO; GO:0007135; P:meiosis II; IMP:TAIR.
DR GO; GO:0009556; P:microsporogenesis; IMP:TAIR.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IMP:TAIR.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Cytoplasm; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..442
FT /note="Cyclin-A1-2"
FT /id="PRO_0000286988"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 283
FT /note="T->I: In tam; alters male meiosis progression."
FT /evidence="ECO:0000269|PubMed:15557098"
SQ SEQUENCE 442 AA; 49637 MW; F1A346EF263D5913 CRC64;
MSSSSRNLSQ ENPIPRPNLA KTRTSLRDVG NRRAPLGDIT NQKNGSRNPS PSSTLVNCSN
KIGQSKKAPK PALSRNWNLG ILDSGLPPKP NAKSNIIVPY EDTELLQSDD SLLCSSPALS
LDASPTQSDP SISTHDSLTN HVVDYMVEST TDDGNDDDDD EIVNIDSDLM DPQLCASFAC
DIYEHLRVSE VNKRPALDYM ERTQSSINAS MRSILIDWLV EVAEEYRLSP ETLYLAVNYV
DRYLTGNAIN KQNLQLLGVT CMMIAAKYEE VCVPQVEDFC YITDNTYLRN ELLEMESSVL
NYLKFELTTP TAKCFLRRFL RAAQGRKEVP SLLSECLACY LTELSLLDYA MLRYAPSLVA
ASAVFLAQYT LHPSRKPWNA TLEHYTSYRA KHMEACVKNL LQLCNEKLSS DVVAIRKKYS
QHKYKFAAKK LCPTSLPQEL FL
