ZN615_PONAB
ID ZN615_PONAB Reviewed; 730 AA.
AC Q5R4K8; Q5R7F4; Q5R900;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc finger protein 615;
GN Name=ZNF615;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; CR859597; CAH91760.1; -; mRNA.
DR EMBL; CR860164; CAH92306.1; -; mRNA.
DR EMBL; CR861238; CAH93308.1; -; mRNA.
DR RefSeq; NP_001126350.1; NM_001132878.1.
DR RefSeq; NP_001128902.1; NM_001135430.1.
DR RefSeq; XP_009231255.1; XM_009232980.1.
DR RefSeq; XP_009231256.1; XM_009232981.1.
DR AlphaFoldDB; Q5R4K8; -.
DR SMR; Q5R4K8; -.
DR GeneID; 100173331; -.
DR GeneID; 100189844; -.
DR KEGG; pon:100189844; -.
DR CTD; 284370; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q5R4K8; -.
DR OMA; CEHNTFA; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF350804; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..730
FT /note="Zinc finger protein 615"
FT /id="PRO_0000311773"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 203..225
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 371..393
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 399..421
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 539..561
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 567..589
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 595..617
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 623..645
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 651..673
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 679..701
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 707..729
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 181
FT /note="T -> I (in Ref. 1; CAH92306)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="R -> G (in Ref. 1; CAH92306)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="L -> P (in Ref. 1; CAH93308)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="Y -> C (in Ref. 1; CAH93308)"
FT /evidence="ECO:0000305"
FT CONFLICT 414
FT /note="L -> P (in Ref. 1; CAH92306)"
FT /evidence="ECO:0000305"
FT CONFLICT 543
FT /note="E -> A (in Ref. 1; CAH92306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 730 AA; 83781 MW; DDE420173A8A8727 CRC64;
MQAQESLTLE DVAVDFTWEE WQFLSPAQKD LYRDVMLENY SNLVAVGFQA SKQDALSKLE
RGEETCTTED EIYSRICFEI RKIDDPLQHH LQNRSIQKSV KQCHEQNMFG NIVNQNKGHF
LLKQDRDTFD LHEKPLKSIL SFENQKRSSG LKNSAEFNGD GKSLFHANHK QFYTEMKFPA
TAKPINKSQF IKQQRTHNIE NAHVCSECGK AFLKLSQFID HQRVHNGEKP HVCSMCGKAF
SRKSRLMDHQ RTHTELKHYE CTECDKTFLK KSQLNIHQKT HMGEKPYTCS ECGKAFIKKC
RLIYHQRTHT GEKPHGCSVC GKAFSTKFSL TTHQKTHTGE KPYICSECGK GFIEKRRLIA
HHRTHTGEKP FICNKCGKGF TLKNSLITHQ QTHTEEKLYT CSECGKGFSM KHCLMVHQRT
HTGEKPYKCN ECGKGFALKS PLIRHQRTHT GEKPYVCTEC RKGFTMKSDL IVHQRTHTAE
KPYICNDCGK GFTVKSRLIV HQRTHTGEKP YVCGECGKGF PAKIRLMGHQ RTHTGEKPYI
CDECGKGFTE KSHLNVHRRT HTGEKPYVCS ECGKGLTGKS MLIAHQRTHT GEKPYICNEC
GKGFTMKSTL SIHQQTHTGE KPYKCNECDK SFRKKTCLIQ HQRFHTGKTS FACTECGKFS
LRKNDLITHQ RIHTGEKPYK CSDCGKAFTT KSGLNVHQRK HTGERPYGCS DCGKAFAHLS
ILVKHKRIHR
