ZN616_HUMAN
ID ZN616_HUMAN Reviewed; 781 AA.
AC Q08AN1; B3KRV1; Q0P658; Q658V7;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Zinc finger protein 616;
GN Name=ZNF616;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-50.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-780, AND VARIANT SER-50.
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK092266; BAG52513.1; -; mRNA.
DR EMBL; BC033199; AAH33199.1; -; mRNA.
DR EMBL; BC125099; AAI25100.1; -; mRNA.
DR EMBL; AL832969; CAH56353.1; -; mRNA.
DR CCDS; CCDS33090.1; -.
DR RefSeq; NP_848618.2; NM_178523.4.
DR AlphaFoldDB; Q08AN1; -.
DR SMR; Q08AN1; -.
DR BioGRID; 124691; 18.
DR IntAct; Q08AN1; 7.
DR MINT; Q08AN1; -.
DR STRING; 9606.ENSP00000471000; -.
DR iPTMnet; Q08AN1; -.
DR PhosphoSitePlus; Q08AN1; -.
DR SwissPalm; Q08AN1; -.
DR BioMuta; ZNF616; -.
DR DMDM; 257050983; -.
DR EPD; Q08AN1; -.
DR jPOST; Q08AN1; -.
DR MassIVE; Q08AN1; -.
DR MaxQB; Q08AN1; -.
DR PaxDb; Q08AN1; -.
DR PeptideAtlas; Q08AN1; -.
DR PRIDE; Q08AN1; -.
DR ProteomicsDB; 58682; -.
DR Antibodypedia; 76364; 8 antibodies from 4 providers.
DR DNASU; 90317; -.
DR Ensembl; ENST00000600228.6; ENSP00000471000.1; ENSG00000204611.7.
DR GeneID; 90317; -.
DR KEGG; hsa:90317; -.
DR MANE-Select; ENST00000600228.6; ENSP00000471000.1; NM_178523.5; NP_848618.2.
DR UCSC; uc002pym.4; human.
DR CTD; 90317; -.
DR GeneCards; ZNF616; -.
DR HGNC; HGNC:28062; ZNF616.
DR HPA; ENSG00000204611; Low tissue specificity.
DR neXtProt; NX_Q08AN1; -.
DR OpenTargets; ENSG00000204611; -.
DR PharmGKB; PA134978923; -.
DR VEuPathDB; HostDB:ENSG00000204611; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164749; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q08AN1; -.
DR OMA; KAYVCNE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q08AN1; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q08AN1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q08AN1; -.
DR BioGRID-ORCS; 90317; 14 hits in 1101 CRISPR screens.
DR GenomeRNAi; 90317; -.
DR Pharos; Q08AN1; Tdark.
DR PRO; PR:Q08AN1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q08AN1; protein.
DR Bgee; ENSG00000204611; Expressed in sural nerve and 130 other tissues.
DR ExpressionAtlas; Q08AN1; baseline and differential.
DR Genevisible; Q08AN1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 21.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 21.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 21.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..781
FT /note="Zinc finger protein 616"
FT /id="PRO_0000280424"
FT DOMAIN 7..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 185..207
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..235
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 241..263
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 269..291
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..599
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 605..627
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 633..655
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 661..683
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 689..711
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 717..739
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 745..767
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 105..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 50
FT /note="P -> S (in dbSNP:rs35582075)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_061960"
FT VARIANT 451
FT /note="H -> R (in dbSNP:rs3764537)"
FT /id="VAR_031149"
SQ SEQUENCE 781 AA; 90273 MW; 487A86A65B70CE10 CRC64;
MATQGHLTFK DVAIEFSQEE WKCLEPVQKA LYKDVMLENY RNLVFLGISP KCVIKELPPT
ENSNTGERFQ TVALERHQSY DIENLYFREI QKHLHDLEFQ WKDGETNDKE VPVPHENNLT
GKRDQHSQGD VENNHIENQL TSNFESRLAE LQKVQTEGRL YECNETEKTG NNGCLVSPHI
REKTYVCNEC GKAFKASSSL INHQRIHTTE KPYKCNECGK AFHRASLLTV HKVVHTRGKS
YQCDVCGKIF RKNSYFVRHQ RSHTGQKPYI CNECGKSFSK SSHLAVHQRI HTGEKPYKCN
LCGKSFSQRV HLRLHQTVHT GERPFKCNEC GKTFKRSSNL TVHQVIHAGK KPYKCDVCGK
AFRHRSNLVC HRRIHSGEKQ YKCNECGKVF SKRSSLAVHR RIHTVEKPCK CNECGKVFSK
RSSLAVHQRI HTGQKTYKCN KCGKVYSKHS HLAVHWRIHT GEKAYKCNEC GKVFSIHSRL
AAHQRIHTGE KPYKCNECGK VFSQHSRLAV HRRIHTGEKP YKCKECGKVF SDRSAFARHR
RIHTGEKPYK CKECGKVFSQ CSRLTVHRRI HSGEKPYKCN ECGKVYSQYS HLVGHRRVHT
GEKPYKCHEC GKAFNQGSTL NRHQRIHTGE KPYKCNQCGN SFSQRVHLRL HQTVHTGDRP
YKCNECGKTF KRSSNLTAHQ IIHAGKKPYK CDECGKVFRH SSHLVSHQRI HTGEKRYKCI
ECGKAFGRLF SLSKHQRIHS GKKPYKCNEC GKSFICRSGL TKHRIRHTGE SLTTKLNVTR
P
