ZN618_MOUSE
ID ZN618_MOUSE Reviewed; 953 AA.
AC Q80YY7; Q69Z57; Q80YY8; Q9CZ99;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Zinc finger protein 618;
GN Name=Znf618; Synonyms=Kiaa1952, Zfp618;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 645-953 (ISOFORM 1).
RC TISSUE=Embryonic intestine;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
CC -!- FUNCTION: Regulates UHRF2 function as a specific 5-
CC hydroxymethylcytosine (5hmC) reader by regulating its chromatin
CC localization. {ECO:0000250|UniProtKB:Q5T7W0}.
CC -!- SUBUNIT: Interacts with UHRF2. {ECO:0000250|UniProtKB:Q5T7W0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5T7W0}.
CC Chromosome {ECO:0000250|UniProtKB:Q5T7W0}. Note=Localizes at genomic
CC loci that are enriched for 5-hydroxymethylcytosine (5hmC).
CC {ECO:0000250|UniProtKB:Q5T7W0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80YY7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80YY7-2; Sequence=VSP_025186, VSP_025184, VSP_025185;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28510.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK012848; BAB28510.1; ALT_FRAME; mRNA.
DR EMBL; AL691431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL691496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK173309; BAD32587.1; -; mRNA.
DR CCDS; CCDS89760.1; -. [Q80YY7-1]
DR AlphaFoldDB; Q80YY7; -.
DR SMR; Q80YY7; -.
DR IntAct; Q80YY7; 1.
DR STRING; 10090.ENSMUSP00000103038; -.
DR iPTMnet; Q80YY7; -.
DR PhosphoSitePlus; Q80YY7; -.
DR MaxQB; Q80YY7; -.
DR PRIDE; Q80YY7; -.
DR ProteomicsDB; 275017; -. [Q80YY7-1]
DR ProteomicsDB; 275018; -. [Q80YY7-2]
DR Antibodypedia; 29860; 36 antibodies from 14 providers.
DR Ensembl; ENSMUST00000107415; ENSMUSP00000103038; ENSMUSG00000028358. [Q80YY7-1]
DR MGI; MGI:1919950; Zfp618.
DR VEuPathDB; HostDB:ENSMUSG00000028358; -.
DR eggNOG; KOG1121; Eukaryota.
DR GeneTree; ENSGT00940000153306; -.
DR InParanoid; Q80YY7; -.
DR PhylomeDB; Q80YY7; -.
DR TreeFam; TF331270; -.
DR ChiTaRS; Zfp618; mouse.
DR PRO; PR:Q80YY7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80YY7; protein.
DR Bgee; ENSMUSG00000028358; Expressed in metanephric cortical collecting duct and 162 other tissues.
DR ExpressionAtlas; Q80YY7; baseline and differential.
DR Genevisible; Q80YY7; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005721; C:pericentric heterochromatin; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001221; F:transcription coregulator binding; ISO:MGI.
DR GO; GO:0035563; P:positive regulation of chromatin binding; ISO:MGI.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Chromosome; DNA-binding;
KW Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..953
FT /note="Zinc finger protein 618"
FT /id="PRO_0000286812"
FT ZN_FING 146..168
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 187..209
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..277
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7W0"
FT CROSSLNK 63
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5T7W0"
FT CROSSLNK 81
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5T7W0"
FT CROSSLNK 238
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5T7W0"
FT CROSSLNK 436
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5T7W0"
FT VAR_SEQ 1..56
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025186"
FT VAR_SEQ 362..441
FT /note="ENTFSRRVESKAQNHFEETNSSSQNSSEPYTCGACGIQFQFYSNLLEHMQSH
FT AADNENNITSNQSRSPPAAVEEKWKPQA -> GTDGLSHRCLPGFPPTTCRSCSPARTR
FT LEFPSCFGADWDPWPLATSVTLADQVINLSWRFIQRNLQTFSKFDVFFSQIMA (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025184"
FT VAR_SEQ 442..953
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025185"
FT CONFLICT 251
FT /note="K -> N (in Ref. 1; BAB28510)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 953 AA; 104866 MW; 6D0F92911E2DC7DC CRC64;
MSQPDGAAAP QVDGASAPGR KSAVNRERLK RSQKSSKVEG PEPVPAEASL SAEQGTMTEV
KVKTEVPDDY IQEVIWQGEA KEEKAGGKDS TGDVPAEICV VIGGVRNQQT LDGKAPEGSP
HGGSVRSRYS GTWIFDQALK YASGSYECGI CGKKYKYYNC FQTHVRAHRD TEATSGEGVS
QSNNFRYTCD ICGKKYKYYS CFQEHRDLHA VDVFSVEGAP ENRADPFDQG VVATDEVKEE
PPEPFQKIGP KTGNYTCEFC GKQYKYYTPY QEHVALHAPI STAPGWEPPE DPDTGSECSH
PEVTPSPRFV AAKTQSNQSG KKAPASVVRC TSLLHRTPPA TQTQTFRAPN SGSPASKAAA
AENTFSRRVE SKAQNHFEET NSSSQNSSEP YTCGACGIQF QFYSNLLEHM QSHAADNENN
ITSNQSRSPP AAVEEKWKPQ AQRNSANNTT TSGLTPNSVI PEKERQNIAE RLLRVMCADL
GALSVVSGKE FLKLAQTLVD SGARYGAFSV TEILGNFNTL ALKHLPRMYN QVKVKVTCAL
GSNACLGIGV TCHSQSVGPD SCYILTAYQA EGNHIKSYVL GVKGADIRDS GDLVHHWVQN
VLSEFVMSEI RTVYVTDCRV STSAFSKAGM CLRCSACALN SVVQSVLSKR TLQARSMHEV
IELLNVCEDL AGSTGLAKET FGSLEETSPP PCWNSVTDSL LLVHERYEQI CEFYSRAKKM
NLIQSLNKHL LSNLAAILTP VKQAVIELSN ESQPTLQLVL PTYVRLEKLF TAKANDAGTV
SKLCHLFLEA LKENFKVHPA HKVAMILDPQ QKLRPVPPYQ HEEIISKVCE LINEVKESWA
EEADFEPAAK KARSATGEHP AAQEEDRLGK NEVYDYLQEP LFQATPDLFQ YWSCVTQKHT
KLAKLAFWLL AVPAVGARSG CVNMCEQALL IKRRRLLSPE DMNKLMFLKS NML
