ZN619_HUMAN
ID ZN619_HUMAN Reviewed; 560 AA.
AC Q8N2I2; B4E271; C9JRN5; D4PHA2; E9PCD9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Zinc finger protein 619;
GN Name=ZNF619;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Thyroid, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N2I2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N2I2-2; Sequence=VSP_043080;
CC Name=3;
CC IsoId=Q8N2I2-3; Sequence=VSP_055715;
CC Name=4;
CC IsoId=Q8N2I2-4; Sequence=VSP_055716;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK075245; BAC11495.1; -; mRNA.
DR EMBL; AK304139; BAG65033.1; -; mRNA.
DR EMBL; AC121754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46801.1; -. [Q8N2I2-2]
DR CCDS; CCDS46802.1; -. [Q8N2I2-4]
DR CCDS; CCDS46803.1; -. [Q8N2I2-3]
DR RefSeq; NP_001138554.1; NM_001145082.2. [Q8N2I2-4]
DR RefSeq; NP_001138555.1; NM_001145083.1. [Q8N2I2-2]
DR RefSeq; NP_001138565.1; NM_001145093.2. [Q8N2I2-3]
DR AlphaFoldDB; Q8N2I2; -.
DR SMR; Q8N2I2; -.
DR BioGRID; 130063; 2.
DR IntAct; Q8N2I2; 2.
DR STRING; 9606.ENSP00000411132; -.
DR iPTMnet; Q8N2I2; -.
DR PhosphoSitePlus; Q8N2I2; -.
DR BioMuta; ZNF619; -.
DR DMDM; 74762517; -.
DR jPOST; Q8N2I2; -.
DR MassIVE; Q8N2I2; -.
DR MaxQB; Q8N2I2; -.
DR PaxDb; Q8N2I2; -.
DR PeptideAtlas; Q8N2I2; -.
DR PRIDE; Q8N2I2; -.
DR Antibodypedia; 29047; 124 antibodies from 15 providers.
DR DNASU; 285267; -.
DR Ensembl; ENST00000314686.9; ENSP00000322529.5; ENSG00000177873.14. [Q8N2I2-1]
DR Ensembl; ENST00000432264.4; ENSP00000388710.2; ENSG00000177873.14. [Q8N2I2-3]
DR Ensembl; ENST00000447116.6; ENSP00000411132.2; ENSG00000177873.14. [Q8N2I2-4]
DR Ensembl; ENST00000456778.5; ENSP00000397232.1; ENSG00000177873.14. [Q8N2I2-2]
DR Ensembl; ENST00000521353.5; ENSP00000430705.1; ENSG00000177873.14. [Q8N2I2-4]
DR GeneID; 285267; -.
DR KEGG; hsa:285267; -.
DR MANE-Select; ENST00000432264.4; ENSP00000388710.2; NM_001145093.4; NP_001138565.1. [Q8N2I2-3]
DR UCSC; uc003ckj.4; human. [Q8N2I2-1]
DR CTD; 285267; -.
DR GeneCards; ZNF619; -.
DR HGNC; HGNC:26910; ZNF619.
DR HPA; ENSG00000177873; Low tissue specificity.
DR neXtProt; NX_Q8N2I2; -.
DR OpenTargets; ENSG00000177873; -.
DR PharmGKB; PA134889198; -.
DR VEuPathDB; HostDB:ENSG00000177873; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163750; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8N2I2; -.
DR OMA; RIHMDKK; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N2I2; -.
DR TreeFam; TF350844; -.
DR PathwayCommons; Q8N2I2; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N2I2; -.
DR BioGRID-ORCS; 285267; 8 hits in 1104 CRISPR screens.
DR ChiTaRS; ZNF619; human.
DR GenomeRNAi; 285267; -.
DR Pharos; Q8N2I2; Tdark.
DR PRO; PR:Q8N2I2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N2I2; protein.
DR Bgee; ENSG00000177873; Expressed in calcaneal tendon and 97 other tissues.
DR ExpressionAtlas; Q8N2I2; baseline and differential.
DR Genevisible; Q8N2I2; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..560
FT /note="Zinc finger protein 619"
FT /id="PRO_0000234601"
FT ZN_FING 188..210
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 216..238
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 244..266
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 272..294
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 300..322
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 328..350
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 356..378
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 384..406
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 412..434
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 440..462
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..82
FT /note="MGQPAPYAEGPIQGGDAGELCKCDFLVSISIPQTRSDIPAGARRSSMGPRSL
FT DTCWGRGPERHVHRLECNGVIFTHRNLCLP -> MKPGVISHAPDSVVPAAFPFPKPDL
FT IFQLEQGEAAWGPDPWTLAGGEALRGMCT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043080"
FT VAR_SEQ 1..82
FT /note="MGQPAPYAEGPIQGGDAGELCKCDFLVSISIPQTRSDIPAGARRSSMGPRSL
FT DTCWGRGPERHVHRLECNGVIFTHRNLCLP -> MLQTVWFQGLGRNLLFQEPVTFEDV
FT AVYFTQNEWASLHPTQRALYREVMLENYANVTSLSAFPFPKPDLIFQLEQGEAAWGPDP
FT WTLAGGEALRGMCT (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_055715"
FT VAR_SEQ 1..82
FT /note="MGQPAPYAEGPIQGGDAGELCKCDFLVSISIPQTRSDIPAGARRSSMGPRSL
FT DTCWGRGPERHVHRLECNGVIFTHRNLCLP -> MLQTVWFQGLGRNLLFQEPVTFEDV
FT AVYFTQNEWASLHPTQRALYREVMLENYANVTSLYPTAGGFPLDTERTEKVPGALSSFL
FT PSSSSLELILALLPMSAFPFPKPDLIFQLEQGEAAWGPDPWTLAGGEALRGMCT (in
FT isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_055716"
SQ SEQUENCE 560 AA; 63322 MW; A65162901A812767 CRC64;
MGQPAPYAEG PIQGGDAGEL CKCDFLVSIS IPQTRSDIPA GARRSSMGPR SLDTCWGRGP
ERHVHRLECN GVIFTHRNLC LPGGKTKTEN EEKTAQLNIS KESESHRLIV EGLLMDVPQH
PDFKDRLEKS QLHDTGNKTK IGDCTDLTVQ DHESSTTERE EIARKLEESS VSTHLITKQG
FAKEQVFYKC GECGSYYNPH SDFHLHQRVH TNEKPYTCKE CGKTFRYNSK LSRHQKIHTG
EKPYSCEECG QAFSQNSHLL QHQKLHGGQR PYECTDCGKT FSYNSKLIRH QRIHTGEKPF
KCKECGKAFS CSYDCIIHER IHNGEKPYEC KECGKSLSSN SVLIQHQRIH TGEKPYECKE
CGKAFHRSSV FLQHQRFHTG EQLYKCNECW KTFSCSSRFI VHQRIHNGEK PYECQECGKT
FSQKITLVQH QRVHTGEKPY ECKECGKAFR WNASFIQHQK WHTRKKLING TGLSAVKPYC
PCAILSPLPP QHTCSALAPP GPPLSSSHAV VLPPSVPFFL LLPSSEKANP SPVQIAHFFQ
DLAFPGKSSL QSPNPLSHSL
