ZN620_HUMAN
ID ZN620_HUMAN Reviewed; 422 AA.
AC Q6ZNG0; Q8N223;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Zinc finger protein 620;
GN Name=ZNF620;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6ZNG0; O94929-2: ABLIM3; NbExp=3; IntAct=EBI-4395669, EBI-11961672;
CC Q6ZNG0; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-4395669, EBI-12006308;
CC Q6ZNG0; Q13515: BFSP2; NbExp=3; IntAct=EBI-4395669, EBI-10229433;
CC Q6ZNG0; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-4395669, EBI-12006120;
CC Q6ZNG0; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-4395669, EBI-747505;
CC Q6ZNG0; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-4395669, EBI-7317823;
CC Q6ZNG0; Q9NP86: CABP5; NbExp=3; IntAct=EBI-4395669, EBI-10311131;
CC Q6ZNG0; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-4395669, EBI-11530605;
CC Q6ZNG0; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-4395669, EBI-10171570;
CC Q6ZNG0; Q16204: CCDC6; NbExp=3; IntAct=EBI-4395669, EBI-1045350;
CC Q6ZNG0; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-4395669, EBI-10175300;
CC Q6ZNG0; P24863: CCNC; NbExp=3; IntAct=EBI-4395669, EBI-395261;
CC Q6ZNG0; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-4395669, EBI-5278764;
CC Q6ZNG0; P55273: CDKN2D; NbExp=3; IntAct=EBI-4395669, EBI-745859;
CC Q6ZNG0; Q13111: CHAF1A; NbExp=3; IntAct=EBI-4395669, EBI-1020839;
CC Q6ZNG0; Q96Q77: CIB3; NbExp=3; IntAct=EBI-4395669, EBI-10292696;
CC Q6ZNG0; Q9BW66: CINP; NbExp=3; IntAct=EBI-4395669, EBI-739784;
CC Q6ZNG0; O95833: CLIC3; NbExp=3; IntAct=EBI-4395669, EBI-10192241;
CC Q6ZNG0; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-4395669, EBI-11962928;
CC Q6ZNG0; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-4395669, EBI-742953;
CC Q6ZNG0; Q86UW9: DTX2; NbExp=3; IntAct=EBI-4395669, EBI-740376;
CC Q6ZNG0; Q96JC9: EAF1; NbExp=3; IntAct=EBI-4395669, EBI-769261;
CC Q6ZNG0; Q96G04: EEF2KMT; NbExp=3; IntAct=EBI-4395669, EBI-747840;
CC Q6ZNG0; Q14240-2: EIF4A2; NbExp=3; IntAct=EBI-4395669, EBI-10232522;
CC Q6ZNG0; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-4395669, EBI-6255981;
CC Q6ZNG0; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-4395669, EBI-371876;
CC Q6ZNG0; Q14192: FHL2; NbExp=3; IntAct=EBI-4395669, EBI-701903;
CC Q6ZNG0; O95995: GAS8; NbExp=3; IntAct=EBI-4395669, EBI-1052570;
CC Q6ZNG0; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-4395669, EBI-748515;
CC Q6ZNG0; P62993: GRB2; NbExp=3; IntAct=EBI-4395669, EBI-401755;
CC Q6ZNG0; P13807: GYS1; NbExp=3; IntAct=EBI-4395669, EBI-740553;
CC Q6ZNG0; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-4395669, EBI-11955401;
CC Q6ZNG0; Q14005-2: IL16; NbExp=3; IntAct=EBI-4395669, EBI-17178971;
CC Q6ZNG0; O75564-2: JRK; NbExp=3; IntAct=EBI-4395669, EBI-17181882;
CC Q6ZNG0; Q7L273: KCTD9; NbExp=3; IntAct=EBI-4395669, EBI-4397613;
CC Q6ZNG0; P25800: LMO1; NbExp=3; IntAct=EBI-4395669, EBI-8639312;
CC Q6ZNG0; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-4395669, EBI-11742507;
CC Q6ZNG0; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-4395669, EBI-746778;
CC Q6ZNG0; Q13163: MAP2K5; NbExp=3; IntAct=EBI-4395669, EBI-307294;
CC Q6ZNG0; Q8WXB1: METTL21A; NbExp=3; IntAct=EBI-4395669, EBI-8652459;
CC Q6ZNG0; P55081: MFAP1; NbExp=3; IntAct=EBI-4395669, EBI-1048159;
CC Q6ZNG0; Q8IVT2: MISP; NbExp=3; IntAct=EBI-4395669, EBI-2555085;
CC Q6ZNG0; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-4395669, EBI-8852072;
CC Q6ZNG0; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-4395669, EBI-5662487;
CC Q6ZNG0; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-4395669, EBI-10249760;
CC Q6ZNG0; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-4395669, EBI-744782;
CC Q6ZNG0; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-4395669, EBI-12025760;
CC Q6ZNG0; Q9UMX2-2: OAZ3; NbExp=3; IntAct=EBI-4395669, EBI-12049527;
CC Q6ZNG0; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-4395669, EBI-14066006;
CC Q6ZNG0; Q92569: PIK3R3; NbExp=3; IntAct=EBI-4395669, EBI-79893;
CC Q6ZNG0; O60568: PLOD3; NbExp=3; IntAct=EBI-4395669, EBI-741582;
CC Q6ZNG0; P56282: POLE2; NbExp=3; IntAct=EBI-4395669, EBI-713847;
CC Q6ZNG0; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-4395669, EBI-10226430;
CC Q6ZNG0; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-4395669, EBI-6257312;
CC Q6ZNG0; Q15020: SART3; NbExp=3; IntAct=EBI-4395669, EBI-308619;
CC Q6ZNG0; O75093: SLIT1; NbExp=3; IntAct=EBI-4395669, EBI-947791;
CC Q6ZNG0; Q92966: SNAPC3; NbExp=3; IntAct=EBI-4395669, EBI-1760638;
CC Q6ZNG0; Q96A09: TENT5B; NbExp=3; IntAct=EBI-4395669, EBI-752030;
CC Q6ZNG0; P07951-2: TPM2; NbExp=3; IntAct=EBI-4395669, EBI-10977815;
CC Q6ZNG0; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-4395669, EBI-3650647;
CC Q6ZNG0; Q9UDY6-2: TRIM10; NbExp=3; IntAct=EBI-4395669, EBI-11981577;
CC Q6ZNG0; Q86XT4: TRIM50; NbExp=3; IntAct=EBI-4395669, EBI-9867283;
CC Q6ZNG0; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-4395669, EBI-372432;
CC Q6ZNG0; Q969E8: TSR2; NbExp=3; IntAct=EBI-4395669, EBI-746981;
CC Q6ZNG0; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-4395669, EBI-14096082;
CC Q6ZNG0; Q05516: ZBTB16; NbExp=3; IntAct=EBI-4395669, EBI-711925;
CC Q6ZNG0; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-4395669, EBI-10237226;
CC Q6ZNG0; Q15915: ZIC1; NbExp=3; IntAct=EBI-4395669, EBI-11963196;
CC Q6ZNG0; P17028: ZNF24; NbExp=3; IntAct=EBI-4395669, EBI-707773;
CC Q6ZNG0; Q5T619: ZNF648; NbExp=3; IntAct=EBI-4395669, EBI-11985915;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZNG0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZNG0-2; Sequence=VSP_016040;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK093599; BAC04203.1; -; mRNA.
DR EMBL; AK131232; BAD18415.1; -; mRNA.
DR CCDS; CCDS33740.1; -. [Q6ZNG0-1]
DR CCDS; CCDS58825.1; -. [Q6ZNG0-2]
DR RefSeq; NP_001243096.1; NM_001256167.1. [Q6ZNG0-2]
DR RefSeq; NP_001243097.1; NM_001256168.1. [Q6ZNG0-2]
DR RefSeq; NP_787084.1; NM_175888.3. [Q6ZNG0-1]
DR RefSeq; XP_005265068.1; XM_005265011.3. [Q6ZNG0-1]
DR RefSeq; XP_005265069.1; XM_005265012.3. [Q6ZNG0-1]
DR RefSeq; XP_016861558.1; XM_017006069.1. [Q6ZNG0-2]
DR AlphaFoldDB; Q6ZNG0; -.
DR SMR; Q6ZNG0; -.
DR BioGRID; 128978; 81.
DR IntAct; Q6ZNG0; 73.
DR STRING; 9606.ENSP00000322265; -.
DR iPTMnet; Q6ZNG0; -.
DR PhosphoSitePlus; Q6ZNG0; -.
DR BioMuta; ZNF620; -.
DR DMDM; 74762397; -.
DR EPD; Q6ZNG0; -.
DR jPOST; Q6ZNG0; -.
DR MassIVE; Q6ZNG0; -.
DR PaxDb; Q6ZNG0; -.
DR PeptideAtlas; Q6ZNG0; -.
DR PRIDE; Q6ZNG0; -.
DR ProteomicsDB; 68021; -. [Q6ZNG0-1]
DR ProteomicsDB; 68022; -. [Q6ZNG0-2]
DR Antibodypedia; 12274; 121 antibodies from 18 providers.
DR DNASU; 253639; -.
DR Ensembl; ENST00000314529.10; ENSP00000322265.6; ENSG00000177842.12. [Q6ZNG0-1]
DR Ensembl; ENST00000418905.1; ENSP00000391472.1; ENSG00000177842.12. [Q6ZNG0-2]
DR GeneID; 253639; -.
DR KEGG; hsa:253639; -.
DR MANE-Select; ENST00000314529.10; ENSP00000322265.6; NM_175888.4; NP_787084.1.
DR UCSC; uc003ckk.5; human. [Q6ZNG0-1]
DR CTD; 253639; -.
DR DisGeNET; 253639; -.
DR GeneCards; ZNF620; -.
DR HGNC; HGNC:28742; ZNF620.
DR HPA; ENSG00000177842; Low tissue specificity.
DR neXtProt; NX_Q6ZNG0; -.
DR OpenTargets; ENSG00000177842; -.
DR PharmGKB; PA134942360; -.
DR VEuPathDB; HostDB:ENSG00000177842; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163769; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q6ZNG0; -.
DR OMA; QISYECR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZNG0; -.
DR TreeFam; TF350844; -.
DR PathwayCommons; Q6ZNG0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZNG0; -.
DR BioGRID-ORCS; 253639; 8 hits in 1100 CRISPR screens.
DR GenomeRNAi; 253639; -.
DR Pharos; Q6ZNG0; Tdark.
DR PRO; PR:Q6ZNG0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZNG0; protein.
DR Bgee; ENSG00000177842; Expressed in adrenal tissue and 106 other tissues.
DR ExpressionAtlas; Q6ZNG0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..422
FT /note="Zinc finger protein 620"
FT /id="PRO_0000047691"
FT DOMAIN 11..82
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 196..218
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016040"
SQ SEQUENCE 422 AA; 48503 MW; 25F673810C3A1923 CRC64;
MFQTAWRQEP VTFEDVAVYF TQNEWASLDS VQRALYREVM LENYANVASL AFPFTTPVLV
SQLEQGELPW GLDPWEPMGR EALRGICPGD EARTEKEGLT PKDHVSKETE SFRLMVGGLP
GNVSQHLDFG SSLEQPQGHW IIKTKSKRRH FTDTSARHHE AYEVKNGEKF EKLGKNISVS
TQLTTNQTNP SGQISYECGQ CGRYFIQMAD FHRHEKCHTG EKSFECKECG KYFRYNSLLI
RHQIIHTGKK PFKCKECGKG LSSDTALIQH QRIHTGEKPY ECKECGKAFS SSSVFLQHQR
FHTGEKLYEC NECWKTFSCS SSFTVHQRMH TGEKPYECKE CGKRLSSNTA LTQHQRIHTG
EKPFECKECG KAFNQKITLI QHQRVHTGEK PYECKVCGKT FSWCGRFILH QKLHTQKTPV
QA
