ZN621_HUMAN
ID ZN621_HUMAN Reviewed; 439 AA.
AC Q6ZSS3; Q14DC7; Q8TE91;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 621;
GN Name=ZNF621;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Corpus callosum, and Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZSS3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZSS3-2; Sequence=VSP_016041, VSP_016042;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK074366; BAB85061.1; -; mRNA.
DR EMBL; AK127181; BAC86873.1; -; mRNA.
DR EMBL; CR749268; CAH18124.1; -; mRNA.
DR EMBL; BC101619; AAI01620.1; -; mRNA.
DR EMBL; BC113415; AAI13416.1; -; mRNA.
DR CCDS; CCDS2693.1; -. [Q6ZSS3-1]
DR CCDS; CCDS74920.1; -. [Q6ZSS3-2]
DR RefSeq; NP_001091884.1; NM_001098414.2. [Q6ZSS3-1]
DR RefSeq; NP_001274174.1; NM_001287245.1. [Q6ZSS3-2]
DR RefSeq; NP_940886.1; NM_198484.4. [Q6ZSS3-1]
DR AlphaFoldDB; Q6ZSS3; -.
DR SMR; Q6ZSS3; -.
DR BioGRID; 130064; 6.
DR IntAct; Q6ZSS3; 5.
DR STRING; 9606.ENSP00000340841; -.
DR iPTMnet; Q6ZSS3; -.
DR PhosphoSitePlus; Q6ZSS3; -.
DR BioMuta; ZNF621; -.
DR DMDM; 74762406; -.
DR jPOST; Q6ZSS3; -.
DR MassIVE; Q6ZSS3; -.
DR PaxDb; Q6ZSS3; -.
DR PeptideAtlas; Q6ZSS3; -.
DR PRIDE; Q6ZSS3; -.
DR ProteomicsDB; 68235; -. [Q6ZSS3-1]
DR ProteomicsDB; 68236; -. [Q6ZSS3-2]
DR Antibodypedia; 12279; 121 antibodies from 20 providers.
DR DNASU; 285268; -.
DR Ensembl; ENST00000310898.5; ENSP00000312144.1; ENSG00000172888.12. [Q6ZSS3-2]
DR Ensembl; ENST00000339296.10; ENSP00000340841.5; ENSG00000172888.12. [Q6ZSS3-1]
DR Ensembl; ENST00000403205.6; ENSP00000386051.2; ENSG00000172888.12. [Q6ZSS3-1]
DR GeneID; 285268; -.
DR KEGG; hsa:285268; -.
DR MANE-Select; ENST00000339296.10; ENSP00000340841.5; NM_198484.5; NP_940886.1.
DR UCSC; uc003ckm.4; human. [Q6ZSS3-1]
DR CTD; 285268; -.
DR GeneCards; ZNF621; -.
DR HGNC; HGNC:24787; ZNF621.
DR HPA; ENSG00000172888; Low tissue specificity.
DR neXtProt; NX_Q6ZSS3; -.
DR OpenTargets; ENSG00000172888; -.
DR PharmGKB; PA134982950; -.
DR VEuPathDB; HostDB:ENSG00000172888; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163271; -.
DR InParanoid; Q6ZSS3; -.
DR OMA; KSKAAWQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZSS3; -.
DR TreeFam; TF350844; -.
DR PathwayCommons; Q6ZSS3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZSS3; -.
DR BioGRID-ORCS; 285268; 8 hits in 1099 CRISPR screens.
DR GenomeRNAi; 285268; -.
DR Pharos; Q6ZSS3; Tdark.
DR PRO; PR:Q6ZSS3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZSS3; protein.
DR Bgee; ENSG00000172888; Expressed in endothelial cell and 166 other tissues.
DR ExpressionAtlas; Q6ZSS3; baseline and differential.
DR Genevisible; Q6ZSS3; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..439
FT /note="Zinc finger protein 621"
FT /id="PRO_0000047693"
FT DOMAIN 11..83
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 151..173
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 179..201
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..229
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 148..157
FT /note="MKFYECKECG -> SVEVRSLRPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016041"
FT VAR_SEQ 158..439
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016042"
SQ SEQUENCE 439 AA; 49205 MW; 6E44DBCE808EA165 CRC64;
MLQTTWPQES VTFEDVAVYF TQNQWASLDP AQRALYGEVM LENYANVASL VAFPFPKPAL
ISHLERGEAP WGPDPWDTEI LRGISQGGES WIKNEGLVIK QEASEETELH RMPVGGLLRN
VSQHFDFKRK ALKQTFNLNP NLILRGGMKF YECKECGKIF RYNSKLIRHQ MSHTGEKPFK
CKECGKAFKS SYDCIVHEKN HIGEGPYECK ECGKGLSSNT ALTQHQRIHT GEKPYECKEC
GKAFRRSAAY LQHQRLHTGE KLYKCKECWK AFGCRSLFIV HQRIHTGEKP YQCKECGKAF
TQKIASIQHQ RVHTGEKPYE CKVCGKAFKW YGSFVQHQKL HPVEKKPVKV LGPSLVSPQC
SSPAIPPVLL QGSCSASAVA VPSLTFPHAV LIPTSGNFFM LLPTSGIPSS SAQIVRVFQG
LTPTVKPSPV ILTPSSHSS
