ID   ZN622_CHICK             Reviewed;         405 AA.
AC   Q90Y35; Q90Y36;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Cytoplasmic 60S subunit biogenesis factor ZNF622 {ECO:0000305};
DE   AltName: Full=Zinc finger protein 622;
DE   AltName: Full=Zn-finger protein C47 {ECO:0000303|PubMed:11319154};
GN   Name=ZNF622;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11319154; DOI=10.1095/biolreprod64.5.1473;
RA   Kim H., You S., Farris J., Foster L.K., Choi Y.-J., Foster D.N.;
RT   "Gonad-specific expression of two novel chicken complementary DNA
RT   isoforms.";
RL   Biol. Reprod. 64:1473-1480(2001).
CC   -!- FUNCTION: Pre-60S-associated cytoplasmic factor involved in the
CC       cytoplasmic maturation of the 60S subunit.
CC       {ECO:0000250|UniProtKB:Q969S3}.
CC   -!- SUBUNIT: Homo- and heterodimer. Associates with pre-60S ribosomal
CC       particles. {ECO:0000250|UniProtKB:Q969S3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969S3}. Nucleus
CC       {ECO:0000250|UniProtKB:Q969S3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=C47L {ECO:0000303|PubMed:11319154};
CC         IsoId=Q90Y35-1; Sequence=Displayed;
CC       Name=2; Synonyms=C47S {ECO:0000303|PubMed:11319154};
CC         IsoId=Q90Y35-2; Sequence=VSP_010810;
CC   -!- TISSUE SPECIFICITY: [Isoform 1]: Mainly expressed in the ovary.
CC       {ECO:0000269|PubMed:11319154}.
CC   -!- TISSUE SPECIFICITY: [Isoform 2]: Mainly expressed in the testis.
CC       {ECO:0000269|PubMed:11319154}.
CC   -!- SIMILARITY: Belongs to the REI1 family. {ECO:0000305}.
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DR   EMBL; AF299386; AAK97212.1; -; mRNA.
DR   EMBL; AF299387; AAK97213.1; -; mRNA.
DR   AlphaFoldDB; Q90Y35; -.
DR   SMR; Q90Y35; -.
DR   STRING; 9031.ENSGALP00000036335; -.
DR   PaxDb; Q90Y35; -.
DR   VEuPathDB; HostDB:geneid_373921; -.
DR   eggNOG; KOG2785; Eukaryota.
DR   InParanoid; Q90Y35; -.
DR   PhylomeDB; Q90Y35; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR   InterPro; IPR040025; Znf622/Rei1/Reh1.
DR   InterPro; IPR022755; Znf_C2H2_jaz.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR13182; PTHR13182; 1.
DR   Pfam; PF12756; zf-C2H2_2; 1.
DR   Pfam; PF12171; zf-C2H2_jaz; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SMART; SM00451; ZnF_U1; 2.
DR   SUPFAM; SSF57667; SSF57667; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Ribosome biogenesis; Zinc; Zinc-finger.
FT   CHAIN           1..405
FT                   /note="Cytoplasmic 60S subunit biogenesis factor ZNF622"
FT                   /id="PRO_0000191818"
FT   ZN_FING         4..28
FT                   /note="U1-type 1"
FT   ZN_FING         67..91
FT                   /note="U1-type 2"
FT   REGION          135..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..230
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         324..405
FT                   /note="KLFTDGDAALEFADFYDFRSSYPDHKEGQDMEVPAELPSDRELEYDDDTMEL
FT                   IPPFRCKSWSSFFNEILQAAVWSVKNGGCY -> NSSQMEMRPWNLQTSMILGAVTLIT
FT                   RKGKTWRCLLSSHPTENWNTMMTPWS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11319154"
FT                   /id="VSP_010810"
SQ   SEQUENCE   405 AA;  46109 MW;  3C5298B22C59A3AF CRC64;
     MATYTCITCR VAFKDADIQR AHYKTDWHRY NLKRKVADMP PVTAENFQER VLAQRAVAEE
     RDKVTATYCT VCSKRFSTFN AYENHLKSKK HLELEKKAVQ AVSKKVKILN EKNLEKGLAV
     ESVDKDEMNA AIQQAIRAQP SSSPKKVPLP PSHASSSPVP MESAGLLQSK ERTQKPPRLQ
     WFEQQAKKLA KQEAEEEEDS EEGWEEMDSD EDLGSEEEME GVEEEEEKQA EAESTCAIGA
     IPVTDCLFCS HHSRTLMKNV AHMTKVHSFF IPDIEYLVDL RGLIKYLGEK IGVGKICIWC
     NEKGKSFYST EAVQAHMNDK SHCKLFTDGD AALEFADFYD FRSSYPDHKE GQDMEVPAEL
     PSDRELEYDD DTMELIPPFR CKSWSSFFNE ILQAAVWSVK NGGCY