ZN622_MOUSE
ID ZN622_MOUSE Reviewed; 476 AA.
AC Q91VY9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cytoplasmic 60S subunit biogenesis factor ZNF622 {ECO:0000305};
DE AltName: Full=Zinc finger protein 622;
GN Name=Znf622; Synonyms=D15Ertd806e, Zfp622;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Pre-60S-associated cytoplasmic factor involved in the
CC cytoplasmic maturation of the 60S subunit.
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- SUBUNIT: Homo- and heterodimer. Associates with pre-60S ribosomal
CC particles. Interacts with MELK and MYBL2. Interacts with DNAJC21.
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969S3}. Nucleus
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- PTM: Phosphorylated by MELK. The phosphorylation may redirect the
CC protein to the nucleus. {ECO:0000250|UniProtKB:Q969S3}.
CC -!- PTM: Ubiquitinated by HECTD1, leading to its degradation.
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- SIMILARITY: Belongs to the REI1 family. {ECO:0000305}.
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DR EMBL; AK031232; BAC27310.1; -; mRNA.
DR EMBL; BC006964; AAH06964.1; -; mRNA.
DR CCDS; CCDS27400.1; -.
DR RefSeq; NP_653106.1; NM_144523.2.
DR AlphaFoldDB; Q91VY9; -.
DR SMR; Q91VY9; -.
DR BioGRID; 206636; 1.
DR IntAct; Q91VY9; 1.
DR STRING; 10090.ENSMUSP00000059678; -.
DR iPTMnet; Q91VY9; -.
DR PhosphoSitePlus; Q91VY9; -.
DR EPD; Q91VY9; -.
DR MaxQB; Q91VY9; -.
DR PaxDb; Q91VY9; -.
DR PRIDE; Q91VY9; -.
DR ProteomicsDB; 299592; -.
DR Antibodypedia; 22565; 179 antibodies from 22 providers.
DR Ensembl; ENSMUST00000061875; ENSMUSP00000059678; ENSMUSG00000052253.
DR GeneID; 52521; -.
DR KEGG; mmu:52521; -.
DR UCSC; uc007vjk.1; mouse.
DR CTD; 52521; -.
DR MGI; MGI:1289282; Zfp622.
DR VEuPathDB; HostDB:ENSMUSG00000052253; -.
DR eggNOG; KOG2785; Eukaryota.
DR GeneTree; ENSGT00390000018047; -.
DR HOGENOM; CLU_018787_0_2_1; -.
DR InParanoid; Q91VY9; -.
DR OMA; YAEYYDY; -.
DR OrthoDB; 1383726at2759; -.
DR PhylomeDB; Q91VY9; -.
DR TreeFam; TF313094; -.
DR BioGRID-ORCS; 52521; 21 hits in 63 CRISPR screens.
DR ChiTaRS; Zfp622; mouse.
DR PRO; PR:Q91VY9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q91VY9; protein.
DR Bgee; ENSMUSG00000052253; Expressed in paneth cell and 246 other tissues.
DR ExpressionAtlas; Q91VY9; baseline and differential.
DR Genevisible; Q91VY9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR GO; GO:0033674; P:positive regulation of kinase activity; ISO:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR InterPro; IPR040025; Znf622/Rei1/Reh1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13182; PTHR13182; 1.
DR Pfam; PF12756; zf-C2H2_2; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF57667; SSF57667; 2.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Ribosome biogenesis; Ubl conjugation; Zinc;
KW Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q969S3"
FT CHAIN 2..476
FT /note="Cytoplasmic 60S subunit biogenesis factor ZNF622"
FT /id="PRO_0000191816"
FT ZN_FING 4..28
FT /note="U1-type 1"
FT ZN_FING 69..93
FT /note="U1-type 2"
FT REGION 137..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..238
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q969S3"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q969S3"
SQ SEQUENCE 476 AA; 53451 MW; 651A9B25964DF6E4 CRC64;
MAALTCITCR VAFRDAELQR AHYKTDWHRY NLRRKVAAMA PVTAEGFQER VRAQRAVAEA
AEASKGAATY CTACGKKFAT FNAYENHLGS RRHAELERKA VRAASRRVEL LNAKNLEKGL
GADGVDKDAV NAAIQQAIKA QPSTSPKKAP FVPTDECGRA AAGARGVPER DPTEKPPRLQ
WFEQQAKKLA KQQWEDGEEE GEEEEEDDED EDWEDIDSDD GLECEDPGVE DQDAEDAAAE
ESPPLGAIPI TDCLFCSHHS SSLVKNVAHM TKVHSFFIPD IEYLSDLKGL IKYLGEKVGV
GKICLWCNEK GKSFYSTEAV QAHMNDKSHC KLFTDGDAAL EFADFYDFRS SYPDYKEGQD
PAELEALSTD KILECDDETM ELILPSGARV GHRSLMRYYK QRFGLPRAVT VARNQKAVGR
VLQQYRALGW MGSTGAALMR ERDMQYVQRM KSKWMLKIGM KNNATKQMHF RAQVRF
