ZN622_RAT
ID ZN622_RAT Reviewed; 386 AA.
AC Q7TM96;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Cytoplasmic 60S subunit biogenesis factor ZNF622 {ECO:0000305};
DE AltName: Full=Liver regeneration-related protein LRRG121;
DE AltName: Full=Zinc finger protein 622;
GN Name=Znf622; ORFNames=Ac1133, Ac2-061, Zfp622;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RA Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Pre-60S-associated cytoplasmic factor involved in the
CC cytoplasmic maturation of the 60S subunit.
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- SUBUNIT: Homo- and heterodimer. Associates with pre-60S ribosomal
CC particles. Interacts with MELK and MYBL2. Interacts with DNAJC21.
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969S3}. Nucleus
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- PTM: Phosphorylated by MELK. The phosphorylation may redirect the
CC protein to the nucleus. {ECO:0000250|UniProtKB:Q969S3}.
CC -!- PTM: Ubiquitinated by HECTD1, leading to its degradation.
CC {ECO:0000250|UniProtKB:Q969S3}.
CC -!- SIMILARITY: Belongs to the REI1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP78750.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP86261.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY310142; AAP78750.1; ALT_INIT; mRNA.
DR EMBL; AY321329; AAP86261.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q7TM96; -.
DR SMR; Q7TM96; -.
DR STRING; 10116.ENSRNOP00000060898; -.
DR jPOST; Q7TM96; -.
DR PaxDb; Q7TM96; -.
DR UCSC; RGD:1309146; rat.
DR RGD; 1309146; Zfp622.
DR VEuPathDB; HostDB:ENSRNOG00000010589; -.
DR eggNOG; KOG2785; Eukaryota.
DR InParanoid; Q7TM96; -.
DR PRO; PR:Q7TM96; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000059443; Expressed in skeletal muscle tissue and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR GO; GO:0033674; P:positive regulation of kinase activity; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR InterPro; IPR040025; Znf622/Rei1/Reh1.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13182; PTHR13182; 1.
DR Pfam; PF12756; zf-C2H2_2; 1.
DR Pfam; PF12171; zf-C2H2_jaz; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SMART; SM00451; ZnF_U1; 2.
DR SUPFAM; SSF57667; SSF57667; 2.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Ribosome biogenesis; Ubl conjugation; Zinc;
KW Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q969S3"
FT CHAIN 2..386
FT /note="Cytoplasmic 60S subunit biogenesis factor ZNF622"
FT /id="PRO_0000191817"
FT ZN_FING 4..28
FT /note="U1-type 1"
FT ZN_FING 67..91
FT /note="U1-type 2"
FT REGION 135..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..234
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q969S3"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q969S3"
SQ SEQUENCE 386 AA; 43890 MW; BE5D56ABD1149E94 CRC64;
MATYTCITCR VAFRDAEMQR AHYKTDWHRY NLRRKVANMA PVTAEGFQER VRAQRAVAEE
ESKGTATYCT VCSKKFATFN AYENHLKSRR HVELEKKAVQ AVSRQVEMMN EKNLEKGLGV
DSVNKDAMNA AIQQAIKAQP STSPKKAPFM PTDESRRVAG AVRRGTPERD PTEKPPRLQW
FEQQAKKLAK QQWEESEEEG EEDDEDWEDI DSDDGLECEN PGVEEEDAED AEAEESPPLG
AIPITDCLFC SHHSSSLVKN VAHMTKVHSF FIPDIEYLSD LKGLIKYLGE KVGVGKICLW
CNEKGKSFYS TEAVQAHMND KSHCKLFTDG DAALEFADFY DFRSSYPDYK EGQDPAEIED
LSSEKILECD DETMELILPS DLEYFD
