ZN623_HUMAN
ID ZN623_HUMAN Reviewed; 536 AA.
AC O75123; A4FU80; B4DGP3; E7ENV5;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 3.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Zinc finger protein 623;
GN Name=ZNF623; Synonyms=KIAA0628;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. X. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:169-176(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-445, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC O75123; P36508: ZNF76; NbExp=3; IntAct=EBI-18560922, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O75123-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O75123-2; Sequence=VSP_053501;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA31603.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG57854.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB014528; BAA31603.2; ALT_INIT; mRNA.
DR EMBL; AK294695; BAG57854.1; ALT_FRAME; mRNA.
DR EMBL; AC067930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC105210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067516; AAH67516.1; -; mRNA.
DR EMBL; BC067517; AAH67517.1; -; mRNA.
DR EMBL; BC067518; AAH67518.1; -; mRNA.
DR EMBL; BC075056; AAH75056.1; -; mRNA.
DR EMBL; BC075057; AAH75057.1; -; mRNA.
DR EMBL; BC112899; AAI12900.1; -; mRNA.
DR CCDS; CCDS34957.1; -. [O75123-1]
DR CCDS; CCDS47931.1; -. [O75123-2]
DR RefSeq; NP_001075949.1; NM_001082480.2. [O75123-2]
DR RefSeq; NP_001248772.1; NM_001261843.1. [O75123-2]
DR RefSeq; NP_055604.3; NM_014789.3. [O75123-1]
DR RefSeq; XP_006716771.1; XM_006716708.3. [O75123-2]
DR AlphaFoldDB; O75123; -.
DR SMR; O75123; -.
DR BioGRID; 115169; 10.
DR IntAct; O75123; 2.
DR MINT; O75123; -.
DR STRING; 9606.ENSP00000445979; -.
DR iPTMnet; O75123; -.
DR PhosphoSitePlus; O75123; -.
DR BioMuta; ZNF623; -.
DR EPD; O75123; -.
DR MassIVE; O75123; -.
DR MaxQB; O75123; -.
DR PaxDb; O75123; -.
DR PeptideAtlas; O75123; -.
DR PRIDE; O75123; -.
DR ProteomicsDB; 17232; -.
DR ProteomicsDB; 49779; -. [O75123-1]
DR Antibodypedia; 48612; 55 antibodies from 16 providers.
DR DNASU; 9831; -.
DR Ensembl; ENST00000458270.2; ENSP00000411139.2; ENSG00000183309.12. [O75123-2]
DR Ensembl; ENST00000501748.3; ENSP00000445979.1; ENSG00000183309.12. [O75123-1]
DR Ensembl; ENST00000526926.6; ENSP00000435232.1; ENSG00000183309.12. [O75123-2]
DR Ensembl; ENST00000618766.2; ENSP00000481049.1; ENSG00000276340.4. [O75123-2]
DR Ensembl; ENST00000620499.4; ENSP00000484164.1; ENSG00000276340.4. [O75123-2]
DR Ensembl; ENST00000633071.1; ENSP00000487869.1; ENSG00000276340.4. [O75123-1]
DR GeneID; 9831; -.
DR KEGG; hsa:9831; -.
DR MANE-Select; ENST00000526926.6; ENSP00000435232.1; NM_001261843.2; NP_001248772.1. [O75123-2]
DR UCSC; uc003yzd.3; human. [O75123-1]
DR CTD; 9831; -.
DR DisGeNET; 9831; -.
DR GeneCards; ZNF623; -.
DR HGNC; HGNC:29084; ZNF623.
DR HPA; ENSG00000183309; Low tissue specificity.
DR neXtProt; NX_O75123; -.
DR OpenTargets; ENSG00000183309; -.
DR PharmGKB; PA134969295; -.
DR VEuPathDB; HostDB:ENSG00000183309; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163183; -.
DR HOGENOM; CLU_002678_44_12_1; -.
DR InParanoid; O75123; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; O75123; -.
DR TreeFam; TF337005; -.
DR PathwayCommons; O75123; -.
DR SignaLink; O75123; -.
DR BioGRID-ORCS; 9831; 13 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF623; human.
DR GenomeRNAi; 9831; -.
DR Pharos; O75123; Tdark.
DR PRO; PR:O75123; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; O75123; protein.
DR Bgee; ENSG00000183309; Expressed in cortical plate and 109 other tissues.
DR Genevisible; O75123; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..536
FT /note="Zinc finger protein 623"
FT /id="PRO_0000047694"
FT ZN_FING 123..145
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 151..173
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 179..201
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..229
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..425
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..453
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 459..481
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 57..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 445
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053501"
FT VARIANT 126
FT /note="D -> N (in dbSNP:rs4874084)"
FT /id="VAR_052881"
SQ SEQUENCE 536 AA; 61393 MW; 714619E8EE7D6B0E CRC64;
MILLSFVSDS NVGTGEKKVT EAWISEDENS HRTTSDRLTV MELPSPESEE VHEPRLGELL
GNPEGQSLGS SPSQDRGCKQ VTVTHWKIQT GETAQVCTKS GRNHILNSDL LLLQRELIEG
EANPCDICGK TFTFNSDLVR HRISHAGEKP YTCDQCGKGF GQSSHLMEHQ RIHTGERLYV
CNVCGKDFIH YSGLIEHQRV HSGEKPFKCA QCGKAFCHSS DLIRHQRVHT RERPFECKEC
GKGFSQSSLL IRHQRIHTGE RPYECNECGK SFIRSSSLIR HYQIHTEVKQ YECKECGKAF
RHRSDLIEHQ RIHTGERPFE CNECGKAFIR SSKLIQHQRI HTGERPYVCN ECGKRFSQTS
NFTQHQRIHT GEKLYECNEC GKAFFLSSYL IRHQKIHTGE RVYECKECGK AFLQKAHLTE
HQKIHSGDRP FECKDCGKAF IQSSKLLLHQ IIHTGEKPYV CSYCGKGFIQ RSNFLQHQKI
HTEEKLYECS QYGRDFNSTT NVKNNQRVHQ EGLSLSKAPI HLGERSVDKG EHTGNL
