ZN625_HUMAN
ID ZN625_HUMAN Reviewed; 306 AA.
AC Q96I27; A4FU45; I3L0E9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Zinc finger protein 625;
GN Name=ZNF625;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-215 (ISOFORM 2).
RA Birkett C., Cho J., Gau Y., Hamer R., Kelly S., Kovacs K., Liu L., Liu X.,
RA Porter J., Sachs A., Shu Y., Sun Z., Wong J., Wu M., Zhang X., Jay G.,
RA He W.;
RT "High-throughput cloning of full-length human cDNAs directly from cDNA
RT libraries optimized for large and rare transcripts.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96I27; Q6A162: KRT40; NbExp=3; IntAct=EBI-4395587, EBI-10171697;
CC Q96I27; P60372: KRTAP10-4; NbExp=3; IntAct=EBI-4395587, EBI-10178153;
CC Q96I27; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-4395587, EBI-10172290;
CC Q96I27; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-4395587, EBI-10172052;
CC Q96I27-2; P28799: GRN; NbExp=3; IntAct=EBI-12038525, EBI-747754;
CC Q96I27-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12038525, EBI-10171774;
CC Q96I27-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-12038525, EBI-5235340;
CC Q96I27-2; O76024: WFS1; NbExp=3; IntAct=EBI-12038525, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96I27-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96I27-2; Sequence=VSP_046327;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC022415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84261.1; -; Genomic_DNA.
DR EMBL; CH471106; EAW84263.1; -; Genomic_DNA.
DR EMBL; BC007868; AAH07868.1; -; mRNA.
DR EMBL; BC101589; AAI01590.1; -; mRNA.
DR EMBL; BC101591; AAI01592.1; -; mRNA.
DR EMBL; BC143563; AAI43564.1; -; mRNA.
DR EMBL; DN991057; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS12269.2; -. [Q96I27-2]
DR RefSeq; NP_660276.2; NM_145233.3. [Q96I27-2]
DR AlphaFoldDB; Q96I27; -.
DR SMR; Q96I27; -.
DR BioGRID; 124739; 15.
DR IntAct; Q96I27; 11.
DR STRING; 9606.ENSP00000394380; -.
DR iPTMnet; Q96I27; -.
DR PhosphoSitePlus; Q96I27; -.
DR BioMuta; ZNF625; -.
DR DMDM; 74762662; -.
DR EPD; Q96I27; -.
DR jPOST; Q96I27; -.
DR MassIVE; Q96I27; -.
DR MaxQB; Q96I27; -.
DR PaxDb; Q96I27; -.
DR PeptideAtlas; Q96I27; -.
DR PRIDE; Q96I27; -.
DR ProteomicsDB; 46343; -.
DR ProteomicsDB; 76808; -. [Q96I27-1]
DR Antibodypedia; 56965; 122 antibodies from 15 providers.
DR DNASU; 90589; -.
DR Ensembl; ENST00000439556.3; ENSP00000394380.2; ENSG00000257591.6. [Q96I27-2]
DR GeneID; 90589; -.
DR KEGG; hsa:90589; -.
DR MANE-Select; ENST00000439556.3; ENSP00000394380.2; NM_145233.4; NP_660276.2. [Q96I27-2]
DR UCSC; uc010dyo.3; human. [Q96I27-1]
DR CTD; 90589; -.
DR GeneCards; ZNF625; -.
DR HGNC; HGNC:30571; ZNF625.
DR HPA; ENSG00000257591; Tissue enhanced (retina).
DR neXtProt; NX_Q96I27; -.
DR OpenTargets; ENSG00000257591; -.
DR PharmGKB; PA134911932; -.
DR VEuPathDB; HostDB:ENSG00000257591; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164670; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q96I27; -.
DR OMA; IRYHERM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96I27; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q96I27; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96I27; -.
DR BioGRID-ORCS; 90589; 14 hits in 1088 CRISPR screens.
DR GenomeRNAi; 90589; -.
DR Pharos; Q96I27; Tdark.
DR PRO; PR:Q96I27; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96I27; protein.
DR Bgee; ENSG00000257591; Expressed in ventricular zone and 92 other tissues.
DR ExpressionAtlas; Q96I27; baseline and differential.
DR Genevisible; Q96I27; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..306
FT /note="Zinc finger protein 625"
FT /id="PRO_0000234602"
FT ZN_FING 31..53
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 69..91
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 97..119
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 125..147
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 153..175
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 181..203
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 209..231
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 287..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 209
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9BS34"
FT VAR_SEQ 1
FT /note="M -> MDSVVFEDVDVNFTQEEWALLDPSQKNLYRDVMQETFRNLASVGKKW
FT KDQKIEDEYKNPRRNLRGLM (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_046327"
FT VARIANT 41
FT /note="V -> M (in dbSNP:rs7258368)"
FT /id="VAR_052882"
SQ SEQUENCE 306 AA; 34746 MW; 49A28E02E8D66464 CRC64;
MGERLLESKK DHQHGEILTQ VPDDMLKKKT PRVKSCGEVS VGHASLNRHH RADTGHKPYE
YQEYGQKPYK CTYCKKAFSD LPYFRTHEWA HTGGKPYDCE ECGKSFISRS SIRRHRIMHS
GDGPYKCNFC GKALMCLSLY LIHKRTHTGE KPYECKQCGK AFSHSGSLRI HERTHTGEKP
YECSECGKAF HSSTCLHAHK ITHTGEKPYE CKQCGKAFVS FNSVRYHERT HTGEKPYECK
QCGKAFRSAS HLRTHGRTHT GEKPYECKQC GKAFGCASSV KIHERTHTGE KPCSSNTSKG
QGEKIA
