ZN626_HUMAN
ID ZN626_HUMAN Reviewed; 528 AA.
AC Q68DY1; Q8N8T4; Q96QM1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 626;
GN Name=ZNF626;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Lung, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q68DY1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68DY1-2; Sequence=VSP_022263;
CC Name=3;
CC IsoId=Q68DY1-3; Sequence=VSP_043270, VSP_043271;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04729.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305};
CC Sequence=CAH18089.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305};
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DR EMBL; AK096221; BAC04729.1; ALT_SEQ; mRNA.
DR EMBL; AK131567; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CR749233; CAH18089.1; ALT_SEQ; mRNA.
DR EMBL; AC010636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84879.1; -; Genomic_DNA.
DR EMBL; BC007116; AAH07116.1; -; mRNA.
DR EMBL; BC107803; AAI07804.1; -; mRNA.
DR CCDS; CCDS32976.1; -. [Q68DY1-3]
DR CCDS; CCDS42535.1; -. [Q68DY1-1]
DR RefSeq; NP_001070143.1; NM_001076675.2. [Q68DY1-1]
DR RefSeq; NP_660340.1; NM_145297.3. [Q68DY1-3]
DR AlphaFoldDB; Q68DY1; -.
DR SMR; Q68DY1; -.
DR BioGRID; 128273; 2.
DR IntAct; Q68DY1; 3.
DR STRING; 9606.ENSP00000469958; -.
DR iPTMnet; Q68DY1; -.
DR PhosphoSitePlus; Q68DY1; -.
DR BioMuta; ZNF626; -.
DR DMDM; 215273916; -.
DR jPOST; Q68DY1; -.
DR MassIVE; Q68DY1; -.
DR PaxDb; Q68DY1; -.
DR PeptideAtlas; Q68DY1; -.
DR PRIDE; Q68DY1; -.
DR ProteomicsDB; 66115; -. [Q68DY1-1]
DR ProteomicsDB; 66116; -. [Q68DY1-2]
DR ProteomicsDB; 66117; -. [Q68DY1-3]
DR Antibodypedia; 56812; 33 antibodies from 8 providers.
DR DNASU; 199777; -.
DR Ensembl; ENST00000291750.6; ENSP00000291750.6; ENSG00000188171.17. [Q68DY1-3]
DR Ensembl; ENST00000601440.6; ENSP00000469958.1; ENSG00000188171.17. [Q68DY1-1]
DR GeneID; 199777; -.
DR KEGG; hsa:199777; -.
DR MANE-Select; ENST00000601440.6; ENSP00000469958.1; NM_001076675.3; NP_001070143.1.
DR UCSC; uc002npb.2; human. [Q68DY1-1]
DR CTD; 199777; -.
DR GeneCards; ZNF626; -.
DR HGNC; HGNC:30461; ZNF626.
DR HPA; ENSG00000188171; Low tissue specificity.
DR neXtProt; NX_Q68DY1; -.
DR OpenTargets; ENSG00000188171; -.
DR PharmGKB; PA134875370; -.
DR VEuPathDB; HostDB:ENSG00000188171; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q68DY1; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q68DY1; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q68DY1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q68DY1; -.
DR BioGRID-ORCS; 199777; 15 hits in 1037 CRISPR screens.
DR ChiTaRS; ZNF626; human.
DR GenomeRNAi; 199777; -.
DR Pharos; Q68DY1; Tdark.
DR PRO; PR:Q68DY1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q68DY1; protein.
DR Bgee; ENSG00000188171; Expressed in buccal mucosa cell and 165 other tissues.
DR ExpressionAtlas; Q68DY1; baseline and differential.
DR Genevisible; Q68DY1; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..528
FT /note="Zinc finger protein 626"
FT /id="PRO_0000270994"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 173..195
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..76
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022263"
FT VAR_SEQ 77..92
FT /note="MCSHFAQDLWPEQSMK -> SFLQVHSESQSPLHDI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043270"
FT VAR_SEQ 93..528
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043271"
FT VARIANT 65
FT /note="M -> T (in dbSNP:rs8106117)"
FT /id="VAR_047338"
FT VARIANT 68
FT /note="N -> H (in dbSNP:rs3209058)"
FT /id="VAR_029837"
FT VARIANT 89
FT /note="Q -> E (in dbSNP:rs8111015)"
FT /id="VAR_047339"
FT VARIANT 90
FT /note="S -> N (in dbSNP:rs8110802)"
FT /id="VAR_047340"
FT VARIANT 464
FT /note="C -> Y (in dbSNP:rs4809072)"
FT /id="VAR_047341"
FT VARIANT 500
FT /note="E -> K (in dbSNP:rs10408597)"
FT /id="VAR_047342"
SQ SEQUENCE 528 AA; 60893 MW; 4F631D271B872653 CRC64;
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGITVSKP DLITCLEQGR
KPLTMKRNEM IAKPSVMCSH FAQDLWPEQS MKDSFQKVVL RRYEKCEHDN LQLKKGCISV
DECKVHKEGY NELNQCLTTT PRKICQCDKY VKVLHQFPNS NGQKRGHTGK KPFKYIECGK
AFKQFSTLTT HKKIHTGGKP YKCEECGKAF NHSCSLTRHK KIHTGEKPYK CEECGKAFKH
SSTLTTHKRN HTGEKPYKCD KCGKAFMSSS TLSKHEIIHT EKKPYKCEEC GKAFNRSSTL
TTHKIIHTGE KPYKCEECDK AFKYSYTLTT HKRIHTEDKP YKCEECGKAF KYSSTLTTHK
RIHTGEKPYK CEECGKAFKR SSDLTTHKII HTGEKPYKCE ECGKAFKYSS NLTTHKKIHT
GERPYKCEEC GKAFNQSSIL TTHRRIHTGE KFYKCEECGK AFKCSSNLTT HKKIHTGERP
YKCEECGKAF NQSSILTTHE RIILERNSTN VKNVAKPSSG PHTLLHIR
