ZN641_HUMAN
ID ZN641_HUMAN Reviewed; 438 AA.
AC Q96N77; B3KS43; B4DNU5; Q8TCQ7; Q8WVE1;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 641;
GN Name=ZNF641;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Fetal heart;
RX PubMed=16343441; DOI=10.1016/j.bbrc.2005.11.124;
RA Qi X., Li Y., Xiao J., Yuan W., Yan Y., Wang Y., Liang S., Zhu C., Chen Y.,
RA Liu M., Wu X.;
RT "Activation of transcriptional activities of AP-1 and SRE by a new zinc-
RT finger protein ZNF641.";
RL Biochem. Biophys. Res. Commun. 339:1155-1164(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Kidney, Lung, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT CYS-231.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-438 (ISOFORM 1), AND VARIANT
RP PRO-363.
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-426, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Transcriptional activator. Activates transcriptional
CC activities of SRE and AP-1. {ECO:0000269|PubMed:16343441}.
CC -!- INTERACTION:
CC Q96N77-2; P48643: CCT5; NbExp=3; IntAct=EBI-12939666, EBI-355710;
CC Q96N77-2; G5E9A7: DMWD; NbExp=3; IntAct=EBI-12939666, EBI-10976677;
CC Q96N77-2; P28799: GRN; NbExp=3; IntAct=EBI-12939666, EBI-747754;
CC Q96N77-2; P04792: HSPB1; NbExp=3; IntAct=EBI-12939666, EBI-352682;
CC Q96N77-2; P42858: HTT; NbExp=18; IntAct=EBI-12939666, EBI-466029;
CC Q96N77-2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-12939666, EBI-10975473;
CC Q96N77-2; P25800: LMO1; NbExp=3; IntAct=EBI-12939666, EBI-8639312;
CC Q96N77-2; P25791-3: LMO2; NbExp=3; IntAct=EBI-12939666, EBI-11959475;
CC Q96N77-2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-12939666, EBI-11742507;
CC Q96N77-2; P07196: NEFL; NbExp=3; IntAct=EBI-12939666, EBI-475646;
CC Q96N77-2; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-12939666, EBI-396669;
CC Q96N77-2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-12939666, EBI-748391;
CC Q96N77-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-12939666, EBI-5235340;
CC Q96N77-2; O76024: WFS1; NbExp=3; IntAct=EBI-12939666, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16343441}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96N77-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96N77-2; Sequence=VSP_024867, VSP_024868;
CC Name=3;
CC IsoId=Q96N77-3; Sequence=VSP_024867, VSP_043422;
CC Name=4;
CC IsoId=Q96N77-4; Sequence=VSP_024867;
CC -!- TISSUE SPECIFICITY: Highly expressed in skeletal muscle, moderate
CC expression in heart, liver, and pancreas, lower expression in placenta,
CC no expression seen in brain, lung, and kidney.
CC {ECO:0000269|PubMed:16343441}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY842285; AAW28082.1; -; mRNA.
DR EMBL; AK055857; BAB71031.1; -; mRNA.
DR EMBL; AK092740; BAG52605.1; -; mRNA.
DR EMBL; AK298064; BAG60357.1; -; mRNA.
DR EMBL; AC024257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471111; EAW57982.1; -; Genomic_DNA.
DR EMBL; BC018090; AAH18090.2; -; mRNA.
DR EMBL; AL713659; CAD28468.1; -; mRNA.
DR CCDS; CCDS53787.1; -. [Q96N77-3]
DR CCDS; CCDS53788.1; -. [Q96N77-4]
DR CCDS; CCDS8763.1; -. [Q96N77-1]
DR RefSeq; NP_001166152.1; NM_001172681.1. [Q96N77-4]
DR RefSeq; NP_001166153.1; NM_001172682.1. [Q96N77-3]
DR RefSeq; NP_689533.2; NM_152320.2. [Q96N77-1]
DR RefSeq; XP_005268695.1; XM_005268638.3. [Q96N77-4]
DR RefSeq; XP_011536199.1; XM_011537897.1. [Q96N77-1]
DR RefSeq; XP_011536200.1; XM_011537898.1. [Q96N77-4]
DR RefSeq; XP_016874286.1; XM_017018797.1.
DR AlphaFoldDB; Q96N77; -.
DR SMR; Q96N77; -.
DR BioGRID; 125718; 21.
DR IntAct; Q96N77; 17.
DR MINT; Q96N77; -.
DR STRING; 9606.ENSP00000437832; -.
DR iPTMnet; Q96N77; -.
DR PhosphoSitePlus; Q96N77; -.
DR BioMuta; ZNF641; -.
DR DMDM; 146328571; -.
DR jPOST; Q96N77; -.
DR MassIVE; Q96N77; -.
DR PaxDb; Q96N77; -.
DR PeptideAtlas; Q96N77; -.
DR PRIDE; Q96N77; -.
DR ProteomicsDB; 3621; -.
DR ProteomicsDB; 77481; -. [Q96N77-1]
DR ProteomicsDB; 77482; -. [Q96N77-2]
DR ProteomicsDB; 77483; -. [Q96N77-3]
DR Antibodypedia; 25642; 63 antibodies from 13 providers.
DR DNASU; 121274; -.
DR Ensembl; ENST00000301042.7; ENSP00000301042.3; ENSG00000167528.13. [Q96N77-1]
DR Ensembl; ENST00000448928.7; ENSP00000394627.3; ENSG00000167528.13. [Q96N77-3]
DR Ensembl; ENST00000544117.6; ENSP00000437832.2; ENSG00000167528.13. [Q96N77-1]
DR Ensembl; ENST00000547026.6; ENSP00000449974.1; ENSG00000167528.13. [Q96N77-4]
DR GeneID; 121274; -.
DR KEGG; hsa:121274; -.
DR MANE-Select; ENST00000547026.6; ENSP00000449974.1; NM_001172681.2; NP_001166152.1. [Q96N77-4]
DR UCSC; uc001rrn.3; human. [Q96N77-1]
DR CTD; 121274; -.
DR DisGeNET; 121274; -.
DR GeneCards; ZNF641; -.
DR HGNC; HGNC:31834; ZNF641.
DR HPA; ENSG00000167528; Low tissue specificity.
DR MIM; 613906; gene.
DR neXtProt; NX_Q96N77; -.
DR OpenTargets; ENSG00000167528; -.
DR PharmGKB; PA142670508; -.
DR VEuPathDB; HostDB:ENSG00000167528; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162121; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q96N77; -.
DR OMA; WESMNIQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96N77; -.
DR TreeFam; TF350829; -.
DR PathwayCommons; Q96N77; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96N77; -.
DR BioGRID-ORCS; 121274; 13 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF641; human.
DR GenomeRNAi; 121274; -.
DR Pharos; Q96N77; Tdark.
DR PRO; PR:Q96N77; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q96N77; protein.
DR Bgee; ENSG00000167528; Expressed in germinal epithelium of ovary and 187 other tissues.
DR ExpressionAtlas; Q96N77; baseline and differential.
DR Genevisible; Q96N77; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..438
FT /note="Zinc finger protein 641"
FT /id="PRO_0000285301"
FT DOMAIN 109..181
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 264..286
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..265
FT /note="Transactivation"
FT REGION 345..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 191
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 426
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..14
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_024867"
FT VAR_SEQ 107..150
FT /note="GLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLR -> VSSA
FT SLGVSCGPITAAFVLLSHQPIDELAHMIING (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043422"
FT VAR_SEQ 398..438
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024868"
FT VARIANT 231
FT /note="S -> C (in dbSNP:rs17851618)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032009"
FT VARIANT 363
FT /note="Q -> P (in dbSNP:rs2732481)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_032010"
FT CONFLICT 26
FT /note="G -> R (in Ref. 5; AAH18090)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="D -> G (in Ref. 1; AAW28082 and 2; BAB71031)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 49528 MW; E3873D1A84CF395D CRC64;
MQAEDRSQFG SAAEMLSEQT AALGTGWESM NVQLDGAEPQ VERGSQEERP WRTVPGPLEH
LCCDLEEEPQ SLQEKAQSAP WVPAIPQEGN TGDWEMAAAL LAAGSQGLVT IKDVSLCFSQ
EEWRSLDPSQ TDFYGEYVMQ ENCGIVVSLR FPIPKLDMLS QLEGGEEQWV PDPQDLEERD
ILRVTYTGDG SEHEGDTPEL EAEPPRMLSS VSEDTVLWNP EHDESWDSMP SSSRGMLLGP
PFLQEDSFSN LLCSTEMDSL LRPHTCPQCG KQFVWGSHLA RHQQTHTGER PYSCLKCEKT
FGRRHHLIRH QKTHLHDKTS RCSECGKNFR CNSHLASHQR VHAEGKSCKG QEVGESPGTR
KRQRAPPVPK CHVCTECGKS FGRRHHLVRH WLTHTGEKPF QCPRCEKSFG RKHHLDRHLL
THQGQSPRNS WDRGTSVF
