ZN641_MOUSE
ID ZN641_MOUSE Reviewed; 422 AA.
AC Q8BZ34; Q14DN8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein 641;
GN Name=Znf641; Synonyms=Zfp641;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional activator. Activates transcriptional
CC activities of SRE and AP-1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BZ34-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZ34-2; Sequence=VSP_024869;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK036826; BAC29594.1; -; mRNA.
DR EMBL; AK136402; BAE22965.1; -; mRNA.
DR EMBL; BC111896; AAI11897.1; -; mRNA.
DR EMBL; BC112418; AAI12419.1; -; mRNA.
DR CCDS; CCDS27789.1; -. [Q8BZ34-1]
DR CCDS; CCDS88831.1; -. [Q8BZ34-2]
DR RefSeq; NP_776130.1; NM_173769.3. [Q8BZ34-1]
DR RefSeq; XP_006521032.1; XM_006520969.3. [Q8BZ34-1]
DR RefSeq; XP_006521033.1; XM_006520970.3. [Q8BZ34-1]
DR RefSeq; XP_006521034.1; XM_006520971.3. [Q8BZ34-2]
DR RefSeq; XP_006521035.1; XM_006520972.3.
DR RefSeq; XP_011243929.1; XM_011245627.2. [Q8BZ34-1]
DR RefSeq; XP_017172093.1; XM_017316604.1. [Q8BZ34-2]
DR AlphaFoldDB; Q8BZ34; -.
DR SMR; Q8BZ34; -.
DR BioGRID; 232110; 2.
DR IntAct; Q8BZ34; 2.
DR STRING; 10090.ENSMUSP00000133212; -.
DR PhosphoSitePlus; Q8BZ34; -.
DR PaxDb; Q8BZ34; -.
DR PRIDE; Q8BZ34; -.
DR Antibodypedia; 25642; 63 antibodies from 13 providers.
DR DNASU; 239652; -.
DR Ensembl; ENSMUST00000023722; ENSMUSP00000023722; ENSMUSG00000022987. [Q8BZ34-2]
DR Ensembl; ENSMUST00000169721; ENSMUSP00000133212; ENSMUSG00000022987. [Q8BZ34-1]
DR GeneID; 239652; -.
DR KEGG; mmu:239652; -.
DR UCSC; uc007xme.1; mouse. [Q8BZ34-1]
DR UCSC; uc007xmf.1; mouse. [Q8BZ34-2]
DR CTD; 239652; -.
DR MGI; MGI:2442788; Zfp641.
DR VEuPathDB; HostDB:ENSMUSG00000022987; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162121; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q8BZ34; -.
DR OMA; WESMNIQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BZ34; -.
DR TreeFam; TF350829; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 239652; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp641; mouse.
DR PRO; PR:Q8BZ34; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BZ34; protein.
DR Bgee; ENSMUSG00000022987; Expressed in hindlimb stylopod muscle and 51 other tissues.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..422
FT /note="Zinc finger protein 641"
FT /id="PRO_0000285302"
FT DOMAIN 95..167
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 250..272
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 356..378
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 384..406
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 157..251
FT /note="Transactivation"
FT /evidence="ECO:0000250"
FT REGION 172..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 410
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96N77"
FT VAR_SEQ 93..106
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024869"
SQ SEQUENCE 422 AA; 47398 MW; E27B9AD71CA87BB1 CRC64;
MLSEQAVGLG TGWEPMNTQL DAAELQSERG TREEGSWRTA PRPLEHLHCG LEDEPLSLQE
KATSVPWVPA VPQEGNTGDW EMAAALLAAG SQGLVTIKDV SLCFSQEEWR SLDPSQTDFY
GEYVMQENCG IVVSLRFPIP KLDMLSQQEG GEDQWAPDPQ DVEGRDILKV TYTGDGGEPQ
GDTPELQVEP PRTLSSVTED TALWNPGQGP SWESMPRNST GMLLSPRFLQ EDTFSRHLHR
TDTDSLLKPH TCPQCGKQFV WGSHLARHQQ THTGERPYSC LKCEKSFGRR HHLIRHQKTH
LHDKPSRCSE CGKSFRCSSH LASHQRVHAD SKSCKGQDFG ESPAAQHCVP PVPKCHVCTE
CGKSFGRRHH LVRHWLTHTG EKPFHCPRCE KSFGRKHHLD RHLLTHQGQS PGSSWDRRTA
AF
