ZN648_HUMAN
ID ZN648_HUMAN Reviewed; 568 AA.
AC Q5T619; B2RP16;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger protein 648;
GN Name=ZNF648;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q5T619; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-11985915, EBI-4400025;
CC Q5T619; Q9BUH8: BEGAIN; NbExp=5; IntAct=EBI-11985915, EBI-742722;
CC Q5T619; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-11985915, EBI-11975051;
CC Q5T619; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-11985915, EBI-739580;
CC Q5T619; Q9BXL6-2: CARD14; NbExp=3; IntAct=EBI-11985915, EBI-12114736;
CC Q5T619; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-11985915, EBI-744556;
CC Q5T619; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-11985915, EBI-10961624;
CC Q5T619; Q86X02: CDR2L; NbExp=3; IntAct=EBI-11985915, EBI-11063830;
CC Q5T619; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-11985915, EBI-739624;
CC Q5T619; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11985915, EBI-3867333;
CC Q5T619; Q92997: DVL3; NbExp=3; IntAct=EBI-11985915, EBI-739789;
CC Q5T619; Q96CN4: EVI5L; NbExp=3; IntAct=EBI-11985915, EBI-749523;
CC Q5T619; A1L4K1: FSD2; NbExp=3; IntAct=EBI-11985915, EBI-5661036;
CC Q5T619; Q08379: GOLGA2; NbExp=3; IntAct=EBI-11985915, EBI-618309;
CC Q5T619; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11985915, EBI-5916454;
CC Q5T619; P54257: HAP1; NbExp=3; IntAct=EBI-11985915, EBI-712814;
CC Q5T619; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-11985915, EBI-10961706;
CC Q5T619; O75031: HSF2BP; NbExp=3; IntAct=EBI-11985915, EBI-7116203;
CC Q5T619; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11985915, EBI-2556193;
CC Q5T619; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11985915, EBI-11959885;
CC Q5T619; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11985915, EBI-10171774;
CC Q5T619; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11985915, EBI-11953334;
CC Q5T619; O95751: LDOC1; NbExp=3; IntAct=EBI-11985915, EBI-740738;
CC Q5T619; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-11985915, EBI-741037;
CC Q5T619; P23508: MCC; NbExp=3; IntAct=EBI-11985915, EBI-307531;
CC Q5T619; Q99750: MDFI; NbExp=5; IntAct=EBI-11985915, EBI-724076;
CC Q5T619; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11985915, EBI-16439278;
CC Q5T619; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11985915, EBI-10172526;
CC Q5T619; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11985915, EBI-11522433;
CC Q5T619; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11985915, EBI-22310682;
CC Q5T619; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-11985915, EBI-10297093;
CC Q5T619; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-11985915, EBI-1051317;
CC Q5T619; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-11985915, EBI-949255;
CC Q5T619; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-11985915, EBI-1210429;
CC Q5T619; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-11985915, EBI-726876;
CC Q5T619; Q92622: RUBCN; NbExp=3; IntAct=EBI-11985915, EBI-2952709;
CC Q5T619; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-11985915, EBI-2212028;
CC Q5T619; Q8N205-2: SYNE4; NbExp=3; IntAct=EBI-11985915, EBI-12099160;
CC Q5T619; Q8NA77: TEX19; NbExp=3; IntAct=EBI-11985915, EBI-13323487;
CC Q5T619; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11985915, EBI-949753;
CC Q5T619; Q13077: TRAF1; NbExp=3; IntAct=EBI-11985915, EBI-359224;
CC Q5T619; Q12933: TRAF2; NbExp=3; IntAct=EBI-11985915, EBI-355744;
CC Q5T619; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-11985915, EBI-725997;
CC Q5T619; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-11985915, EBI-742740;
CC Q5T619; Q8WW36: ZCCHC13; NbExp=3; IntAct=EBI-11985915, EBI-954111;
CC Q5T619; P15622-3: ZNF250; NbExp=5; IntAct=EBI-11985915, EBI-10177272;
CC Q5T619; Q3ZCT1: ZNF260; NbExp=3; IntAct=EBI-11985915, EBI-10241410;
CC Q5T619; Q9NSD4: ZNF275; NbExp=3; IntAct=EBI-11985915, EBI-17263125;
CC Q5T619; Q96PQ6: ZNF317; NbExp=3; IntAct=EBI-11985915, EBI-1210473;
CC Q5T619; Q6P1L6: ZNF343; NbExp=3; IntAct=EBI-11985915, EBI-10252492;
CC Q5T619; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-11985915, EBI-11962468;
CC Q5T619; Q9H707: ZNF552; NbExp=3; IntAct=EBI-11985915, EBI-2555731;
CC Q5T619; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-11985915, EBI-4395669;
CC Q5T619; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11985915, EBI-625509;
CC Q5T619; Q9NQZ8: ZNF71; NbExp=3; IntAct=EBI-11985915, EBI-7138235;
CC Q5T619; Q9H5H4: ZNF768; NbExp=3; IntAct=EBI-11985915, EBI-1210580;
CC Q5T619; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11985915, EBI-10240849;
CC Q5T619; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11985915, EBI-11962574;
CC Q5T619; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11985915, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AL355482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137223; AAI37224.1; -; mRNA.
DR EMBL; BC137224; AAI37225.1; -; mRNA.
DR CCDS; CCDS30952.1; -.
DR RefSeq; NP_001009992.1; NM_001009992.1.
DR RefSeq; XP_016855790.1; XM_017000301.1.
DR RefSeq; XP_016855791.1; XM_017000302.1.
DR AlphaFoldDB; Q5T619; -.
DR SMR; Q5T619; -.
DR BioGRID; 126074; 63.
DR IntAct; Q5T619; 60.
DR STRING; 9606.ENSP00000344129; -.
DR iPTMnet; Q5T619; -.
DR PhosphoSitePlus; Q5T619; -.
DR BioMuta; ZNF648; -.
DR DMDM; 74762240; -.
DR MassIVE; Q5T619; -.
DR PaxDb; Q5T619; -.
DR PeptideAtlas; Q5T619; -.
DR PRIDE; Q5T619; -.
DR ProteomicsDB; 64563; -.
DR Antibodypedia; 47087; 81 antibodies from 16 providers.
DR DNASU; 127665; -.
DR Ensembl; ENST00000339948.3; ENSP00000344129.3; ENSG00000179930.6.
DR GeneID; 127665; -.
DR KEGG; hsa:127665; -.
DR MANE-Select; ENST00000339948.3; ENSP00000344129.3; NM_001009992.1; NP_001009992.1.
DR UCSC; uc001goz.3; human.
DR CTD; 127665; -.
DR GeneCards; ZNF648; -.
DR HGNC; HGNC:18190; ZNF648.
DR HPA; ENSG00000179930; Not detected.
DR neXtProt; NX_Q5T619; -.
DR OpenTargets; ENSG00000179930; -.
DR PharmGKB; PA134974398; -.
DR VEuPathDB; HostDB:ENSG00000179930; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163676; -.
DR HOGENOM; CLU_002678_80_0_1; -.
DR InParanoid; Q5T619; -.
DR OMA; QHIRVHN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5T619; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q5T619; -.
DR SignaLink; Q5T619; -.
DR BioGRID-ORCS; 127665; 21 hits in 1086 CRISPR screens.
DR ChiTaRS; ZNF648; human.
DR GenomeRNAi; 127665; -.
DR Pharos; Q5T619; Tdark.
DR PRO; PR:Q5T619; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T619; protein.
DR Bgee; ENSG00000179930; Expressed in liver and 13 other tissues.
DR ExpressionAtlas; Q5T619; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..568
FT /note="Zinc finger protein 648"
FT /id="PRO_0000252162"
FT ZN_FING 279..301
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..358
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 532..554
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 42
FT /note="E -> K (in dbSNP:rs12564283)"
FT /id="VAR_052887"
FT VARIANT 111
FT /note="N -> K (in dbSNP:rs12568050)"
FT /id="VAR_033585"
SQ SEQUENCE 568 AA; 62341 MW; A751072B8C9810F4 CRC64;
MAQVDSQDRW GEASPLSSLT EEAHDTQMLS MNLESDDEDG GEAEKEGTAD PVACPRGSSP
VTHENPDLPW PHPLGKEEEK FSDSSSAGGM GQKPVEMSGK ASWSRDVTKI NETQGSPGAS
RALGSLPSGL AHKLLGQMQP LGDRLPAGDD GYSGANQDAV LDVPPSFPSN GKYLCAHKSV
DTSAGNSSLL CFPRPGSNWD LPTQETHTPA QASATPASLA AAVLAKARNS RKVQNQAGRR
EGGEAEARPY RCLRGGRAFQ KPSKPLSPAE TRGGAAKRYA CELCGKAYSH RGTLQQHRRL
HTGERPYQCS FCDKAYTWSS DHRKHIRTHT GEKPYPCPDC GKAFVRSSDL RKHQRNMHSN
NKPFPCSECG LTFNKPLSLL RHQRTHLGAK PFRCPACDRE FAVASRMVEH QRVHSGERPF
PCPTCGKCFT KSSNLSEHQT LHTGQRPFKC ADCGVAFAQP SRLVRHQRIH TGERPFPCTQ
CGQAFARSST LKRHQQIHSG EKGFLCAECG RAFRIASELA QHIRMHNGER PYQCEDCGQA
FTRSNHLQRH RAKHGTCKKE PIPSSSDE
