ZN654_MOUSE
ID ZN654_MOUSE Reviewed; 1112 AA.
AC Q9DAU9; A0A140LI34; Q8K390;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 3.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 654 {ECO:0000305};
GN Name=Znf654 {ECO:0000250|UniProtKB:Q8IZM8}; Synonyms=Zfp654;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 610-1112.
RC STRAIN=FVB/N; TISSUE=Embryo, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 489-1112.
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1111, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1111, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27760.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH68018.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB24088.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CT030641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027760; AAH27760.1; ALT_INIT; mRNA.
DR EMBL; BC068018; AAH68018.1; ALT_INIT; mRNA.
DR EMBL; AK005508; BAB24088.2; ALT_INIT; mRNA.
DR CCDS; CCDS84250.1; -.
DR RefSeq; NP_001334174.1; NM_001347245.1.
DR RefSeq; NP_082335.1; NM_028059.2.
DR AlphaFoldDB; Q9DAU9; -.
DR STRING; 10090.ENSMUSP00000052946; -.
DR iPTMnet; Q9DAU9; -.
DR PhosphoSitePlus; Q9DAU9; -.
DR EPD; Q9DAU9; -.
DR MaxQB; Q9DAU9; -.
DR PaxDb; Q9DAU9; -.
DR PeptideAtlas; Q9DAU9; -.
DR PRIDE; Q9DAU9; -.
DR ProteomicsDB; 314788; -.
DR Antibodypedia; 32053; 130 antibodies from 23 providers.
DR DNASU; 72020; -.
DR Ensembl; ENSMUST00000207826; ENSMUSP00000146656; ENSMUSG00000047141.
DR GeneID; 72020; -.
DR KEGG; mmu:72020; -.
DR UCSC; uc007zqd.1; mouse.
DR CTD; 72020; -.
DR MGI; MGI:1919270; Zfp654.
DR VEuPathDB; HostDB:ENSMUSG00000047141; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000183034; -.
DR HOGENOM; CLU_026570_1_0_1; -.
DR InParanoid; Q9DAU9; -.
DR OMA; TFKCPAN; -.
DR OrthoDB; 355592at2759; -.
DR PhylomeDB; Q9DAU9; -.
DR TreeFam; TF326007; -.
DR BioGRID-ORCS; 72020; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp654; mouse.
DR PRO; PR:Q9DAU9; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9DAU9; protein.
DR Bgee; ENSMUSG00000047141; Expressed in spermatid and 245 other tissues.
DR ExpressionAtlas; Q9DAU9; baseline and differential.
DR Genevisible; Q9DAU9; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1112
FT /note="Zinc finger protein 654"
FT /id="PRO_0000311947"
FT ZN_FING 566..588
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 738..763
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 779..801
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 807..831
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 836..860
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 482..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1107
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1111
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 1112 AA; 126445 MW; BA59294CDC9BF871 CRC64;
MAEEESDQEA ERLGEELVAI VESPPGPVGL LAAGDGRGGA GGGGCGGGVG ISSRDYCRRF
CQVVEDYAGR WQVPLPQLQV LQTALCCFTS ASASFPDECE HVQYVLSSLA VSFFELLLFF
GRDEFYEEPL KDILGSFQEC QNHLRRYGNV NLELVTRIIK DGGPWEDPVL QAVLKAQPAS
QEIVNKYLSS ENPLFFELRA RYLIACERIP EAMALIKSCI NHPEISKDLY FHQALFTCLF
MSPVEDQLFR EHLLKTDCKS GIDIICNTEK EGKTLLALQL CESFLIPQLQ NGDMYYIWEL
IFLWSKLQLK SNPSKQVFVD QCYQLLRTAT NVRVIFPFMK IIKDEVEEEG LQICVEICGC
ALQLDLHDDP ETKCLIYKTI AHFLPNDLEI VRVCALSVFF LERSLDAYHT VEELYRRPDE
EYSEGMSTVQ NRVRFELLPI LKKGLFFDPE FWNFVMIKKN CVALLRDKSA VKLLNENTLE
NPSSSLKKRV DQQSVEEDQS TGETDPDDAS VVQPKGQVNV KRSLSALNTS KVDHSVPRHR
CMLCNKEFLG GHIVRHAQAH QKKGSFACVI CGRKFRNRGL MQKHLKNHVK KIQRQQIATA
QQDDPEVITL EEINGSKSLI SFENGNSNTK GLEIETLTAS SERNKEVIRE HMAEFIKIPI
AIPENAIENI IENGKPDASF NNISESLPQC DDDYEEEENE DDYEDDYDLN QETSVLHKIN
GTVCHPKDVY ATDQEGNFKC PALGCVRIFK RIGFLNMHAR TVHPTDLNVR QTVMKWSKGK
CKFCQRQFED SQHFIDHLNR HSYPNVYFCL HFNCNESFKL PFQLAQHTKS HRIFQAQCSF
PECHELFEDL PLLYEHEAQH YLSKTPESSA QLSEVVPNHQ EIDPFSNENQ TIHHPVSTSK
SRKYSTEPKT YIDTMEKKTD SLVHNGNEHS DDTVSNISLI DQKMPAIEPN PENTHSTTDL
VNGHSEIEQT PLVTSDPTLK IDINRNRTEN GSILPSVESQ EHSALSVSQA PSKPNLTSEQ
TSYGLIVTKP FVRPLPPSYL DERYLSMPKR RKFLTDIVDA CSDQDNMYKK PVKRLRCGKC
LTTYCNAEAL EAHLAQKKCQ TLFGFDSDDE SA
