ZN655_HUMAN
ID ZN655_HUMAN Reviewed; 491 AA.
AC Q8N720; A4D291; A6NGD3; B4E3M4; B7Z9Q9; D6W5T4; Q8IV00; Q8TA89; Q96EZ3;
AC Q9BQ85;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Zinc finger protein 655;
DE AltName: Full=Vav-interacting Krueppel-like protein;
GN Name=ZNF655; Synonyms=VIK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH VAV1 AND CDK4.
RX PubMed=15558030; DOI=10.1038/sj.onc.1208043;
RA Houlard M., Romero-Portillo F., Germani A., Depaux A., Regnier-Ricard F.,
RA Gisselbrecht S., Varin-Blank N.;
RT "Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.";
RL Oncogene 24:28-38(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Brain, Small intestine, Trachea, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ASP-52.
RC TISSUE=Brain, Cervix, Pancreas, Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-77; LYS-190 AND LYS-201, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBUNIT: Interacts with VAV1 and CDK4. {ECO:0000269|PubMed:15558030}.
CC -!- INTERACTION:
CC Q8N720; Q9UKU0-7: ACSL6; NbExp=3; IntAct=EBI-625509, EBI-12883224;
CC Q8N720; X5D778: ANKRD11; NbExp=3; IntAct=EBI-625509, EBI-17183751;
CC Q8N720; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-625509, EBI-541426;
CC Q8N720; Q9NWX5: ASB6; NbExp=3; IntAct=EBI-625509, EBI-6425205;
CC Q8N720; O95671: ASMTL; NbExp=3; IntAct=EBI-625509, EBI-743231;
CC Q8N720; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-625509, EBI-1166928;
CC Q8N720; Q99728: BARD1; NbExp=3; IntAct=EBI-625509, EBI-473181;
CC Q8N720; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-625509, EBI-10193358;
CC Q8N720; Q13895: BYSL; NbExp=3; IntAct=EBI-625509, EBI-358049;
CC Q8N720; Q6P047: C8orf74; NbExp=3; IntAct=EBI-625509, EBI-8466055;
CC Q8N720; Q9Y6W3: CAPN7; NbExp=3; IntAct=EBI-625509, EBI-1765641;
CC Q8N720; Q9H257: CARD9; NbExp=3; IntAct=EBI-625509, EBI-751319;
CC Q8N720; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-625509, EBI-11530605;
CC Q8N720; Q8NA61: CBY2; NbExp=4; IntAct=EBI-625509, EBI-741724;
CC Q8N720; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-625509, EBI-744311;
CC Q8N720; H3BU77: CCDC179; NbExp=3; IntAct=EBI-625509, EBI-17766379;
CC Q8N720; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-625509, EBI-10961624;
CC Q8N720; Q96AQ1: CCDC74A; NbExp=3; IntAct=EBI-625509, EBI-8466689;
CC Q8N720; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-625509, EBI-10175300;
CC Q8N720; P51946: CCNH; NbExp=3; IntAct=EBI-625509, EBI-741406;
CC Q8N720; Q16543: CDC37; NbExp=3; IntAct=EBI-625509, EBI-295634;
CC Q8N720; P11802: CDK4; NbExp=6; IntAct=EBI-625509, EBI-295644;
CC Q8N720; Q86X02: CDR2L; NbExp=3; IntAct=EBI-625509, EBI-11063830;
CC Q8N720; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-625509, EBI-1104570;
CC Q8N720; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-625509, EBI-12012272;
CC Q8N720; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-625509, EBI-739773;
CC Q8N720; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-625509, EBI-5453285;
CC Q8N720; Q8NFT6-2: DBF4B; NbExp=3; IntAct=EBI-625509, EBI-12205861;
CC Q8N720; Q05D60: DEUP1; NbExp=3; IntAct=EBI-625509, EBI-748597;
CC Q8N720; Q92785: DPF2; NbExp=3; IntAct=EBI-625509, EBI-359932;
CC Q8N720; Q13115: DUSP4; NbExp=3; IntAct=EBI-625509, EBI-6591081;
CC Q8N720; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-625509, EBI-1175354;
CC Q8N720; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-625509, EBI-74090;
CC Q8N720; Q9Y6C2-2: EMILIN1; NbExp=3; IntAct=EBI-625509, EBI-11748557;
CC Q8N720; Q9UI08-2: EVL; NbExp=3; IntAct=EBI-625509, EBI-6448852;
CC Q8N720; Q9NQT4: EXOSC5; NbExp=5; IntAct=EBI-625509, EBI-371876;
CC Q8N720; O95864-3: FADS2; NbExp=3; IntAct=EBI-625509, EBI-12057609;
CC Q8N720; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-625509, EBI-745689;
CC Q8N720; Q8TBF8: FAM81A; NbExp=3; IntAct=EBI-625509, EBI-11993062;
CC Q8N720; Q96LP2: FAM81B; NbExp=3; IntAct=EBI-625509, EBI-10290827;
CC Q8N720; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-625509, EBI-6658203;
CC Q8N720; O95363: FARS2; NbExp=3; IntAct=EBI-625509, EBI-2513774;
CC Q8N720; Q14192: FHL2; NbExp=3; IntAct=EBI-625509, EBI-701903;
CC Q8N720; O75344: FKBP6; NbExp=3; IntAct=EBI-625509, EBI-744771;
CC Q8N720; P55040: GEM; NbExp=3; IntAct=EBI-625509, EBI-744104;
CC Q8N720; P14136: GFAP; NbExp=3; IntAct=EBI-625509, EBI-744302;
CC Q8N720; P09211: GSTP1; NbExp=3; IntAct=EBI-625509, EBI-353467;
CC Q8N720; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-625509, EBI-11978177;
CC Q8N720; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-625509, EBI-11956675;
CC Q8N720; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-625509, EBI-5460660;
CC Q8N720; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-625509, EBI-748420;
CC Q8N720; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-625509, EBI-746704;
CC Q8N720; P09067: HOXB5; NbExp=3; IntAct=EBI-625509, EBI-3893317;
CC Q8N720; P37235: HPCAL1; NbExp=3; IntAct=EBI-625509, EBI-749311;
CC Q8N720; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-625509, EBI-3918847;
CC Q8N720; P42858: HTT; NbExp=14; IntAct=EBI-625509, EBI-466029;
CC Q8N720; Q13907-2: IDI1; NbExp=3; IntAct=EBI-625509, EBI-13341351;
CC Q8N720; Q9NV31: IMP3; NbExp=3; IntAct=EBI-625509, EBI-747481;
CC Q8N720; Q9NVR2: INTS10; NbExp=3; IntAct=EBI-625509, EBI-536703;
CC Q8N720; Q96PC2: IP6K3; NbExp=3; IntAct=EBI-625509, EBI-10990676;
CC Q8N720; P18084: ITGB5; NbExp=3; IntAct=EBI-625509, EBI-1223434;
CC Q8N720; O75564-2: JRK; NbExp=3; IntAct=EBI-625509, EBI-17181882;
CC Q8N720; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-625509, EBI-2125614;
CC Q8N720; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-625509, EBI-14069005;
CC Q8N720; Q6A162: KRT40; NbExp=3; IntAct=EBI-625509, EBI-10171697;
CC Q8N720; Q01546: KRT76; NbExp=3; IntAct=EBI-625509, EBI-2952745;
CC Q8N720; P78386: KRT85; NbExp=3; IntAct=EBI-625509, EBI-1049371;
CC Q8N720; O43790: KRT86; NbExp=3; IntAct=EBI-625509, EBI-9996498;
CC Q8N720; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-625509, EBI-3958099;
CC Q8N720; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-625509, EBI-11958364;
CC Q8N720; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-625509, EBI-10245291;
CC Q8N720; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-625509, EBI-10246358;
CC Q8N720; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-625509, EBI-11955689;
CC Q8N720; Q8TCE9: LGALS14; NbExp=5; IntAct=EBI-625509, EBI-10274069;
CC Q8N720; P25791-3: LMO2; NbExp=3; IntAct=EBI-625509, EBI-11959475;
CC Q8N720; Q8TBB1: LNX1; NbExp=5; IntAct=EBI-625509, EBI-739832;
CC Q8N720; Q8WV35: LRRC29; NbExp=3; IntAct=EBI-625509, EBI-10276755;
CC Q8N720; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-625509, EBI-2683507;
CC Q8N720; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-625509, EBI-77889;
CC Q8N720; Q96E03: MAGEA2B; NbExp=3; IntAct=EBI-625509, EBI-10239285;
CC Q8N720; O95983-2: MBD3; NbExp=3; IntAct=EBI-625509, EBI-11978579;
CC Q8N720; Q13503: MED21; NbExp=3; IntAct=EBI-625509, EBI-394678;
CC Q8N720; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-625509, EBI-1104564;
CC Q8N720; Q8WXB1: METTL21A; NbExp=3; IntAct=EBI-625509, EBI-8652459;
CC Q8N720; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-625509, EBI-1104552;
CC Q8N720; Q8WV92: MITD1; NbExp=3; IntAct=EBI-625509, EBI-2691489;
CC Q8N720; Q13368: MPP3; NbExp=3; IntAct=EBI-625509, EBI-716157;
CC Q8N720; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-625509, EBI-995714;
CC Q8N720; Q13084: MRPL28; NbExp=3; IntAct=EBI-625509, EBI-723426;
CC Q8N720; Q96QG7: MTMR9; NbExp=3; IntAct=EBI-625509, EBI-744593;
CC Q8N720; P50539-3: MXI1; NbExp=3; IntAct=EBI-625509, EBI-10211940;
CC Q8N720; P41227: NAA10; NbExp=3; IntAct=EBI-625509, EBI-747693;
CC Q8N720; O14777: NDC80; NbExp=3; IntAct=EBI-625509, EBI-715849;
CC Q8N720; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-625509, EBI-10172876;
CC Q8N720; Q9NPG2: NGB; NbExp=3; IntAct=EBI-625509, EBI-10311409;
CC Q8N720; Q6P988: NOTUM; NbExp=3; IntAct=EBI-625509, EBI-16147014;
CC Q8N720; O43809: NUDT21; NbExp=3; IntAct=EBI-625509, EBI-355720;
CC Q8N720; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-625509, EBI-10297093;
CC Q8N720; Q9NPJ8-3: NXT2; NbExp=3; IntAct=EBI-625509, EBI-10698339;
CC Q8N720; O43482: OIP5; NbExp=3; IntAct=EBI-625509, EBI-536879;
CC Q8N720; Q01804: OTUD4; NbExp=3; IntAct=EBI-625509, EBI-1054396;
CC Q8N720; Q99572: P2RX7; NbExp=3; IntAct=EBI-625509, EBI-1753251;
CC Q8N720; Q96AL5: PBX3; NbExp=3; IntAct=EBI-625509, EBI-741171;
CC Q8N720; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-625509, EBI-11956269;
CC Q8N720; P16118: PFKFB1; NbExp=3; IntAct=EBI-625509, EBI-709807;
CC Q8N720; O15160: POLR1C; NbExp=3; IntAct=EBI-625509, EBI-1055079;
CC Q8N720; P0CG20: PRR35; NbExp=3; IntAct=EBI-625509, EBI-11986293;
CC Q8N720; Q6NUQ1: RINT1; NbExp=5; IntAct=EBI-625509, EBI-726876;
CC Q8N720; P23921: RRM1; NbExp=3; IntAct=EBI-625509, EBI-717006;
CC Q8N720; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-625509, EBI-11984663;
CC Q8N720; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-625509, EBI-747035;
CC Q8N720; O43699-3: SIGLEC6; NbExp=3; IntAct=EBI-625509, EBI-12161783;
CC Q8N720; Q9UP95: SLC12A4; NbExp=3; IntAct=EBI-625509, EBI-7244836;
CC Q8N720; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-625509, EBI-358489;
CC Q8N720; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-625509, EBI-2872322;
CC Q8N720; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-625509, EBI-12023934;
CC Q8N720; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-625509, EBI-5235340;
CC Q8N720; O43610: SPRY3; NbExp=3; IntAct=EBI-625509, EBI-12290641;
CC Q8N720; A0A286YEY3: SRGAP2B; NbExp=3; IntAct=EBI-625509, EBI-17766455;
CC Q8N720; Q5T011-5: SZT2; NbExp=3; IntAct=EBI-625509, EBI-10245139;
CC Q8N720; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-625509, EBI-11955057;
CC Q8N720; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-625509, EBI-750487;
CC Q8N720; O15482: TEX28P2; NbExp=3; IntAct=EBI-625509, EBI-751954;
CC Q8N720; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-625509, EBI-3925505;
CC Q8N720; P62072: TIMM10; NbExp=3; IntAct=EBI-625509, EBI-1200391;
CC Q8N720; Q9UKI8: TLK1; NbExp=3; IntAct=EBI-625509, EBI-740492;
CC Q8N720; Q12933: TRAF2; NbExp=3; IntAct=EBI-625509, EBI-355744;
CC Q8N720; O00463: TRAF5; NbExp=3; IntAct=EBI-625509, EBI-523498;
CC Q8N720; P0DI81-3: TRAPPC2; NbExp=3; IntAct=EBI-625509, EBI-11961968;
CC Q8N720; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-625509, EBI-725997;
CC Q8N720; Q6ZMU5: TRIM72; NbExp=3; IntAct=EBI-625509, EBI-2341648;
CC Q8N720; Q9UJ04: TSPYL4; NbExp=3; IntAct=EBI-625509, EBI-308511;
CC Q8N720; O14530: TXNDC9; NbExp=3; IntAct=EBI-625509, EBI-707554;
CC Q8N720; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-625509, EBI-739895;
CC Q8N720; P15498: VAV1; NbExp=5; IntAct=EBI-625509, EBI-625518;
CC Q8N720; O14972: VPS26C; NbExp=3; IntAct=EBI-625509, EBI-7207091;
CC Q8N720; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-625509, EBI-9031083;
CC Q8N720; P23025: XPA; NbExp=3; IntAct=EBI-625509, EBI-295222;
CC Q8N720; P62699: YPEL5; NbExp=3; IntAct=EBI-625509, EBI-11721624;
CC Q8N720; Q05516: ZBTB16; NbExp=3; IntAct=EBI-625509, EBI-711925;
CC Q8N720; Q53FD0-2: ZC2HC1C; NbExp=5; IntAct=EBI-625509, EBI-14104088;
CC Q8N720; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-625509, EBI-373456;
CC Q8N720; Q9H707: ZNF552; NbExp=3; IntAct=EBI-625509, EBI-2555731;
CC Q8N720; Q5T619: ZNF648; NbExp=3; IntAct=EBI-625509, EBI-11985915;
CC Q8N720; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-625509, EBI-10240849;
CC Q8N720; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-625509, EBI-11962574;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N720-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N720-2; Sequence=VSP_036030, VSP_036031;
CC Name=3;
CC IsoId=Q8N720-3; Sequence=VSP_041157;
CC Name=4;
CC IsoId=Q8N720-4; Sequence=VSP_044809, VSP_044810;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY099353; AAM33786.1; -; mRNA.
DR EMBL; AK027114; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK304785; BAG65536.1; -; mRNA.
DR EMBL; AK314593; BAG37165.1; -; mRNA.
DR EMBL; AK316024; BAH14395.1; -; mRNA.
DR EMBL; AC005020; AAS02017.1; -; Genomic_DNA.
DR EMBL; CH236956; EAL23871.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76650.1; -; Genomic_DNA.
DR EMBL; CH236956; EAL23870.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76651.1; -; Genomic_DNA.
DR EMBL; BC000823; AAH00823.1; -; mRNA.
DR EMBL; BC004288; AAH04288.1; -; mRNA.
DR EMBL; BC007378; AAH07378.1; -; mRNA.
DR EMBL; BC011816; AAH11816.1; -; mRNA.
DR EMBL; BC024770; AAH24770.1; -; mRNA.
DR EMBL; BC037407; AAH37407.1; -; mRNA.
DR CCDS; CCDS34695.1; -. [Q8N720-4]
DR CCDS; CCDS47655.1; -. [Q8N720-3]
DR CCDS; CCDS5669.1; -. [Q8N720-1]
DR CCDS; CCDS5670.1; -. [Q8N720-2]
DR RefSeq; NP_001009958.1; NM_001009958.1. [Q8N720-4]
DR RefSeq; NP_001009960.1; NM_001009960.1. [Q8N720-1]
DR RefSeq; NP_001077425.1; NM_001083956.1. [Q8N720-3]
DR RefSeq; NP_001078835.1; NM_001085366.1. [Q8N720-4]
DR RefSeq; NP_001078836.1; NM_001085367.1. [Q8N720-2]
DR RefSeq; NP_001078837.1; NM_001085368.1. [Q8N720-3]
DR RefSeq; NP_076966.1; NM_024061.3. [Q8N720-2]
DR RefSeq; NP_612503.1; NM_138494.2. [Q8N720-1]
DR RefSeq; XP_016868092.1; XM_017012603.1.
DR RefSeq; XP_016868093.1; XM_017012604.1.
DR RefSeq; XP_016868095.1; XM_017012606.1.
DR RefSeq; XP_016868096.1; XM_017012607.1. [Q8N720-1]
DR AlphaFoldDB; Q8N720; -.
DR SMR; Q8N720; -.
DR BioGRID; 122495; 172.
DR DIP; DIP-34108N; -.
DR IntAct; Q8N720; 159.
DR MINT; Q8N720; -.
DR STRING; 9606.ENSP00000393876; -.
DR iPTMnet; Q8N720; -.
DR PhosphoSitePlus; Q8N720; -.
DR BioMuta; ZNF655; -.
DR DMDM; 116242863; -.
DR EPD; Q8N720; -.
DR jPOST; Q8N720; -.
DR MassIVE; Q8N720; -.
DR MaxQB; Q8N720; -.
DR PeptideAtlas; Q8N720; -.
DR PRIDE; Q8N720; -.
DR ProteomicsDB; 1117; -.
DR ProteomicsDB; 72255; -. [Q8N720-1]
DR ProteomicsDB; 72256; -. [Q8N720-2]
DR ProteomicsDB; 72257; -. [Q8N720-3]
DR Antibodypedia; 16203; 86 antibodies from 15 providers.
DR DNASU; 79027; -.
DR Ensembl; ENST00000252713.9; ENSP00000252713.4; ENSG00000197343.11. [Q8N720-1]
DR Ensembl; ENST00000320583.9; ENSP00000322363.5; ENSG00000197343.11. [Q8N720-2]
DR Ensembl; ENST00000357864.6; ENSP00000350530.2; ENSG00000197343.11. [Q8N720-4]
DR Ensembl; ENST00000394163.2; ENSP00000377718.2; ENSG00000197343.11. [Q8N720-1]
DR Ensembl; ENST00000424881.5; ENSP00000393876.1; ENSG00000197343.11. [Q8N720-3]
DR Ensembl; ENST00000440391.5; ENSP00000396396.1; ENSG00000197343.11. [Q8N720-4]
DR Ensembl; ENST00000493277.5; ENSP00000419135.1; ENSG00000197343.11. [Q8N720-3]
DR GeneID; 79027; -.
DR KEGG; hsa:79027; -.
DR MANE-Select; ENST00000252713.9; ENSP00000252713.4; NM_138494.3; NP_612503.1.
DR UCSC; uc003urc.4; human. [Q8N720-1]
DR CTD; 79027; -.
DR DisGeNET; 79027; -.
DR GeneCards; ZNF655; -.
DR HGNC; HGNC:30899; ZNF655.
DR HPA; ENSG00000197343; Low tissue specificity.
DR MIM; 617891; gene.
DR neXtProt; NX_Q8N720; -.
DR OpenTargets; ENSG00000197343; -.
DR PharmGKB; PA134883537; -.
DR VEuPathDB; HostDB:ENSG00000197343; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00760000119441; -.
DR HOGENOM; CLU_127743_0_0_1; -.
DR InParanoid; Q8N720; -.
DR OMA; DECGLAY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N720; -.
DR TreeFam; TF344137; -.
DR PathwayCommons; Q8N720; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N720; -.
DR BioGRID-ORCS; 79027; 12 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF655; human.
DR GeneWiki; ZNF655; -.
DR GenomeRNAi; 79027; -.
DR Pharos; Q8N720; Tbio.
DR PRO; PR:Q8N720; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N720; protein.
DR Bgee; ENSG00000197343; Expressed in ileal mucosa and 179 other tissues.
DR ExpressionAtlas; Q8N720; baseline and differential.
DR Genevisible; Q8N720; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..491
FT /note="Zinc finger protein 655"
FT /id="PRO_0000047700"
FT ZN_FING 212..234
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 303..325
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..353
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 77
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 190
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 201
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 45
FT /note="G -> GGFPISKPDGISQLEQDLQVFDLETKTREVLRDDCS (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041157"
FT VAR_SEQ 46..181
FT /note="DGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLE
FT RLQEILRKFLYLEREFRQITISKETFTSEKNNECHEPEKSFSLDSTIDADQRVLRIQNT
FT DDNDKYDMSFNQNSASGKHEHLNLT -> APPVPQVPALPREGSPGDQAAALLTARYQE
FT FVTFEDVAVHLTREEWGYLDPVQRDLYREVMLENYGNVVSLGILLRLPTTRIHSVNSCP
FT ALSHTQASAFSGETLAVLTAGISKRWPKYRLPIDIARPCSETPFPRL (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036030"
FT VAR_SEQ 46..110
FT /note="DGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLE
FT RLQEILRKFLYLE -> GILLRLPTTRIHSVNSCPALSHTQASAFSGETLAVLTAGISK
FT RWPKYRLPIDIARPCSETPFPRL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044809"
FT VAR_SEQ 111..491
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044810"
FT VAR_SEQ 182..491
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036031"
FT VARIANT 52
FT /note="E -> D (in dbSNP:rs17853754)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028165"
FT CONFLICT 178
FT /note="L -> S (in Ref. 2; BAH14395)"
FT /evidence="ECO:0000305"
FT MOD_RES Q8N720-2:60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231"
SQ SEQUENCE 491 AA; 57407 MW; 04FD791D769C3A80 CRC64;
MEEIPAQEAA GSPRVQFQSL ETQSECLSPE PQFVQDTDME QGLTGDGETR EENKLLIPKQ
KISEEVHSYK VRVGRLKHDI TQVPETREVY KSEDRLERLQ EILRKFLYLE REFRQITISK
ETFTSEKNNE CHEPEKSFSL DSTIDADQRV LRIQNTDDND KYDMSFNQNS ASGKHEHLNL
TEDFQSSECK ESLMDLSHLN KWESIPNTEK SYKCDVCGKI FHQSSALTRH QRIHTREKPY
KCKECEKSFS QSSSLSRHKR IHTREKPYKC EASDKSCEAS DKSCSPSSGI IQHKKIHTRA
KSYKCSSCER VFSRSVHLTQ HQKIHKEMPC KCTVCGSDFC HTSYLLEHQR VHHEEKAYEY
DEYGLAYIKQ QGIHFREKPY TCSECGKDFR LNSHLIQHQR IHTGEKAHEC NECGKAFSQT
SCLIQHHKMH RKEKSYECNE YEGSFSHSSD LILQQEVLTR QKAFDCDVWE KNSSQRAHLV
QHQSIHTKEN S
