ZN660_HUMAN
ID ZN660_HUMAN Reviewed; 331 AA.
AC Q6AZW8; Q7Z331; Q8N9M8;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 660;
GN Name=ZNF660;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Astrocyte;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-331.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6AZW8; Q9NYL2-2: MAP3K20; NbExp=3; IntAct=EBI-12376497, EBI-10255081;
CC Q6AZW8; Q15287: RNPS1; NbExp=3; IntAct=EBI-12376497, EBI-395959;
CC Q6AZW8; O00560: SDCBP; NbExp=3; IntAct=EBI-12376497, EBI-727004;
CC Q6AZW8; Q15973: ZNF124; NbExp=3; IntAct=EBI-12376497, EBI-2555767;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK094189; BAC04303.1; -; mRNA.
DR EMBL; BC075094; AAH75094.1; -; mRNA.
DR EMBL; BC075095; AAH75095.1; -; mRNA.
DR EMBL; BX538171; CAD98047.1; -; mRNA.
DR CCDS; CCDS2716.1; -.
DR RefSeq; NP_775929.2; NM_173658.2.
DR RefSeq; XP_005265147.1; XM_005265090.4.
DR RefSeq; XP_006713180.1; XM_006713117.3.
DR RefSeq; XP_011531924.1; XM_011533622.2.
DR AlphaFoldDB; Q6AZW8; -.
DR SMR; Q6AZW8; -.
DR BioGRID; 130088; 5.
DR IntAct; Q6AZW8; 6.
DR STRING; 9606.ENSP00000324605; -.
DR iPTMnet; Q6AZW8; -.
DR PhosphoSitePlus; Q6AZW8; -.
DR BioMuta; ZNF660; -.
DR DMDM; 74762291; -.
DR jPOST; Q6AZW8; -.
DR MassIVE; Q6AZW8; -.
DR MaxQB; Q6AZW8; -.
DR PaxDb; Q6AZW8; -.
DR PeptideAtlas; Q6AZW8; -.
DR PRIDE; Q6AZW8; -.
DR ProteomicsDB; 66201; -.
DR Antibodypedia; 12502; 121 antibodies from 20 providers.
DR DNASU; 285349; -.
DR Ensembl; ENST00000322734.2; ENSP00000324605.2; ENSG00000144792.9.
DR Ensembl; ENST00000625494.1; ENSP00000487319.1; ENSG00000280661.2.
DR GeneID; 285349; -.
DR KEGG; hsa:285349; -.
DR MANE-Select; ENST00000322734.2; ENSP00000324605.2; NM_173658.4; NP_775929.2.
DR UCSC; uc003cnl.2; human.
DR CTD; 285349; -.
DR DisGeNET; 285349; -.
DR GeneCards; ZNF660; -.
DR HGNC; HGNC:26720; ZNF660.
DR HPA; ENSG00000144792; Low tissue specificity.
DR neXtProt; NX_Q6AZW8; -.
DR OpenTargets; ENSG00000144792; -.
DR PharmGKB; PA134920595; -.
DR VEuPathDB; HostDB:ENSG00000144792; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163766; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; Q6AZW8; -.
DR OMA; KTRNFKQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6AZW8; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q6AZW8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6AZW8; -.
DR BioGRID-ORCS; 285349; 11 hits in 1087 CRISPR screens.
DR GenomeRNAi; 285349; -.
DR Pharos; Q6AZW8; Tdark.
DR PRO; PR:Q6AZW8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6AZW8; protein.
DR Bgee; ENSG00000144792; Expressed in calcaneal tendon and 104 other tissues.
DR ExpressionAtlas; Q6AZW8; baseline and differential.
DR Genevisible; Q6AZW8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..331
FT /note="Zinc finger protein 660"
FT /id="PRO_0000047701"
FT ZN_FING 50..72
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 78..100
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 106..128
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 134..156
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 162..184
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CONFLICT 57
FT /note="K -> N (in Ref. 1; BAC04303)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 38270 MW; 0F78D1090AA32CB4 CRC64;
MRRKTRNFKH KTVKDNKVLT EGSDQESEKD NSQCCDPATN ERVQAEKRQY VCTECGKAFS
QSANLTVHER IHTGEKPYKC KECGKAFSHS SNLVVHRRIH TGLKPYTCSE CGKSFSGKSH
LIRHQGIHSG EKTYECKECG KAFSRSSGLI SHHRVHTGEK PYSCIECGKA FSRSSNLTQH
QRMHRGKKVY KCKECGKTCG SNTKIMDHQR IHTGEKPYEC DECGKTFILR KTLNEHQRLH
RREKPYKCNE CGKAFTSNRN LVDHQRVHTG EKPYKCNECG KTFRQTSQVI LHLRTHTKEK
PYKCSECGKA YRYSSQLIQH QRKHNEEKET S
