ZN662_HUMAN
ID ZN662_HUMAN Reviewed; 426 AA.
AC Q6ZS27; A1A4T9; F8W7S8; Q6ZNF8; Q6ZQW8;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 662;
GN Name=ZNF662;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, Brain, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ZS27-3; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-10255155, EBI-11962928;
CC Q6ZS27-3; Q99750: MDFI; NbExp=3; IntAct=EBI-10255155, EBI-724076;
CC Q6ZS27-3; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-10255155, EBI-928842;
CC Q6ZS27-3; Q13077: TRAF1; NbExp=3; IntAct=EBI-10255155, EBI-359224;
CC Q6ZS27-3; Q12933: TRAF2; NbExp=3; IntAct=EBI-10255155, EBI-355744;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZS27-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZS27-2; Sequence=VSP_020745;
CC Name=3;
CC IsoId=Q6ZS27-3; Sequence=VSP_053783, VSP_053784, VSP_053785;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI28086.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK127779; BAC87129.1; -; mRNA.
DR EMBL; AK128676; BAC87565.1; -; mRNA.
DR EMBL; AK131235; BAD18417.1; -; mRNA.
DR EMBL; AC092043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128085; AAI28086.1; ALT_INIT; mRNA.
DR CCDS; CCDS2708.1; -. [Q6ZS27-1]
DR CCDS; CCDS46807.1; -. [Q6ZS27-3]
DR RefSeq; NP_001128128.1; NM_001134656.1. [Q6ZS27-3]
DR RefSeq; NP_997287.2; NM_207404.3. [Q6ZS27-1]
DR AlphaFoldDB; Q6ZS27; -.
DR SMR; Q6ZS27; -.
DR BioGRID; 132979; 6.
DR IntAct; Q6ZS27; 7.
DR iPTMnet; Q6ZS27; -.
DR PhosphoSitePlus; Q6ZS27; -.
DR BioMuta; ZNF662; -.
DR DMDM; 74758793; -.
DR jPOST; Q6ZS27; -.
DR MassIVE; Q6ZS27; -.
DR PeptideAtlas; Q6ZS27; -.
DR PRIDE; Q6ZS27; -.
DR ProteomicsDB; 30001; -.
DR ProteomicsDB; 68185; -. [Q6ZS27-1]
DR ProteomicsDB; 68186; -. [Q6ZS27-2]
DR TopDownProteomics; Q6ZS27-1; -. [Q6ZS27-1]
DR Antibodypedia; 45656; 120 antibodies from 14 providers.
DR DNASU; 389114; -.
DR Ensembl; ENST00000328199.6; ENSP00000329264.6; ENSG00000182983.15. [Q6ZS27-3]
DR Ensembl; ENST00000440367.7; ENSP00000405047.2; ENSG00000182983.15. [Q6ZS27-1]
DR GeneID; 389114; -.
DR KEGG; hsa:389114; -.
DR MANE-Select; ENST00000440367.7; ENSP00000405047.2; NM_207404.4; NP_997287.2.
DR UCSC; uc003cmi.3; human. [Q6ZS27-1]
DR CTD; 389114; -.
DR DisGeNET; 389114; -.
DR GeneCards; ZNF662; -.
DR HGNC; HGNC:31930; ZNF662.
DR HPA; ENSG00000182983; Low tissue specificity.
DR neXtProt; NX_Q6ZS27; -.
DR OpenTargets; ENSG00000182983; -.
DR PharmGKB; PA142670510; -.
DR VEuPathDB; HostDB:ENSG00000182983; -.
DR GeneTree; ENSGT00940000163753; -.
DR HOGENOM; CLU_002678_0_0_1; -.
DR InParanoid; Q6ZS27; -.
DR OMA; GPSLICT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZS27; -.
DR TreeFam; TF342076; -.
DR PathwayCommons; Q6ZS27; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZS27; -.
DR BioGRID-ORCS; 389114; 14 hits in 1101 CRISPR screens.
DR GenomeRNAi; 389114; -.
DR Pharos; Q6ZS27; Tdark.
DR PRO; PR:Q6ZS27; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZS27; protein.
DR Bgee; ENSG00000182983; Expressed in oviduct epithelium and 135 other tissues.
DR ExpressionAtlas; Q6ZS27; baseline and differential.
DR Genevisible; Q6ZS27; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..426
FT /note="Zinc finger protein 662"
FT /id="PRO_0000251196"
FT DOMAIN 1..44
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 192..214
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 220..242
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 248..270
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 276..298
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..326
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1
FT /note="M -> MAAVALASGTRLGLVLELLPGQPALPRARRESVTFEDVAVYFSENEW
FT IGLGPAQRALYRDVM (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_053783"
FT VAR_SEQ 2..109
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020745"
FT VAR_SEQ 12
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_053784"
FT VAR_SEQ 51..84
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_053785"
FT VARIANT 176
FT /note="N -> S (in dbSNP:rs60980399)"
FT /id="VAR_061961"
FT CONFLICT 389
FT /note="K -> R (in Ref. 1; BAC87565)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 48496 MW; C43690B7773AF3DE CRC64;
MLENYGAVAS LAAFPFPKPA LISQLERGET PWCSVPRGAL DGEAPRGISS GYPFLKPAGI
SHPEQVEEPL NLKLQGEGPS LICPEGVLKR KKEDFILKEE IIEEAQDLMV LSSGPQWCGS
QELWFGKTCE EKSRLGRWPG YLNGGRMESS TNDIIEVIVK DEMISVEESS GNTDVNNLLG
IHHKILNEQI FYICEECGKC FDQNEDFDQH QKTHNGEKVY GCKECGKAFS FRSHCIAHQR
IHSGVKPYEC QECAKAFVWK SNLIRHQRIH TGEKPFECKE CGKGFSQNTS LTQHQRIHTG
EKPYTCKECG KSFTRNPALL RHQRMHTGEK PYECKDCGKG FMWNSDLSQH QRVHTGDKPH
ECTDCGKSFF CKAHLIRHQR IHTGERPYKC NDCGKAFSQN SVLIKHQRRH ARDKPYNCQI
SHLLEH
