ID   ZN664_CAVPO             Reviewed;         261 AA.
AC   Q60493;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Zinc finger protein 664;
DE   AltName: Full=Zinc finger protein from organ of Corti;
GN   Name=ZNF664; Synonyms=ZFOC1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=NIH 2; TISSUE=Organ of Corti;
RX   PubMed=8634327; DOI=10.1016/0167-4781(96)00022-x;
RA   Rivolta M.N., Negrini C., Wilcox E.R.;
RT   "A novel zinc finger gene preferentially expressed in the retina and the
RT   organ of Corti localizes to human chromosome 12q24.3.";
RL   Biochim. Biophys. Acta 1306:127-132(1996).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the organ of Corti, stria vascularis,
CC       auditory nerve and retina. Lower levels in the tongue, cerebellum,
CC       small intestine and kidney. {ECO:0000269|PubMed:8634327}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; L26335; AAC42091.1; -; mRNA.
DR   PIR; S70006; S70006.
DR   RefSeq; NP_001166361.1; NM_001172890.1.
DR   AlphaFoldDB; Q60493; -.
DR   SMR; Q60493; -.
DR   STRING; 10141.ENSCPOP00000013001; -.
DR   BindingDB; Q60493; -.
DR   ChEMBL; CHEMBL4105757; -.
DR   GeneID; 100379578; -.
DR   KEGG; cpoc:100379578; -.
DR   CTD; 144348; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q60493; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   2: Evidence at transcript level;
KW   DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..261
FT                   /note="Zinc finger protein 664"
FT                   /id="PRO_0000296272"
FT   ZN_FING         3..25
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         31..53
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         59..81
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         87..109
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         115..137
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         143..165
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         171..193
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         199..221
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         227..249
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CROSSLNK        257
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N3J9"
SQ   SEQUENCE   261 AA;  30280 MW;  ACE5BD4A96FE9DEF CRC64;
     MIYKCPMCRE FFSERADLFM HQKVHTAEKP HKCDKCDKGF FHISELHIHW RDHTGEKVYK
     CDDCGKDFST TTKLNRHKKI HTVEKPYKCY ECGKAFNWSP HLQIHMRVHT GEKPYVCSEC
     GRGFSNSSNL CMHQRVHTGE KPFKCEECGK AFRHTSSLCM HQRVHTGEKP YKCYECGKAF
     SQSSSLCIHQ RVHTGEKPYR CCGCGKAFSQ SSSLCIHQRV HTGEKPFKCD ECGKAFSQST
     SLCIHQRVHT KERNHLKISV I