ZN664_HUMAN
ID ZN664_HUMAN Reviewed; 261 AA.
AC Q8N3J9; B3KP97; Q15914; Q3ZCQ7;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Zinc finger protein 664;
DE AltName: Full=Zinc finger protein 176 {ECO:0000312|HGNC:HGNC:25406};
DE AltName: Full=Zinc finger protein from organ of Corti;
GN Name=ZNF664 {ECO:0000312|HGNC:HGNC:25406};
GN Synonyms=ZFOC1, ZNF176 {ECO:0000312|HGNC:HGNC:25406};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Cervix adenocarcinoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-207.
RC TISSUE=Retina;
RX PubMed=8634327; DOI=10.1016/0167-4781(96)00022-x;
RA Rivolta M.N., Negrini C., Wilcox E.R.;
RT "A novel zinc finger gene preferentially expressed in the retina and the
RT organ of Corti localizes to human chromosome 12q24.3.";
RL Biochim. Biophys. Acta 1306:127-132(1996).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-257, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N3J9; Q9NP86: CABP5; NbExp=3; IntAct=EBI-2799450, EBI-10311131;
CC Q8N3J9; Q96Q77: CIB3; NbExp=3; IntAct=EBI-2799450, EBI-10292696;
CC Q8N3J9; O95257: GADD45G; NbExp=3; IntAct=EBI-2799450, EBI-448202;
CC Q8N3J9; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-2799450, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK056034; BAG51609.1; -; mRNA.
DR EMBL; AL834266; CAD38941.1; -; mRNA.
DR EMBL; BX647762; CAH10567.1; -; mRNA.
DR EMBL; CH471054; EAW98441.1; -; Genomic_DNA.
DR EMBL; BC051696; AAH51696.1; -; mRNA.
DR EMBL; BC093848; AAH93848.1; -; mRNA.
DR EMBL; BC101530; AAI01531.1; -; mRNA.
DR EMBL; L41669; AAC41997.1; -; mRNA.
DR CCDS; CCDS9257.1; -.
DR PIR; S70007; S70007.
DR RefSeq; NP_001191227.1; NM_001204298.1.
DR RefSeq; NP_689650.1; NM_152437.2.
DR AlphaFoldDB; Q8N3J9; -.
DR SMR; Q8N3J9; -.
DR BioGRID; 126844; 27.
DR IntAct; Q8N3J9; 11.
DR STRING; 9606.ENSP00000441405; -.
DR iPTMnet; Q8N3J9; -.
DR PhosphoSitePlus; Q8N3J9; -.
DR BioMuta; ZNF664; -.
DR DMDM; 74759851; -.
DR EPD; Q8N3J9; -.
DR jPOST; Q8N3J9; -.
DR MassIVE; Q8N3J9; -.
DR MaxQB; Q8N3J9; -.
DR PaxDb; Q8N3J9; -.
DR PeptideAtlas; Q8N3J9; -.
DR PRIDE; Q8N3J9; -.
DR ProteomicsDB; 71817; -.
DR Antibodypedia; 31859; 43 antibodies from 16 providers.
DR DNASU; 144348; -.
DR Ensembl; ENST00000337815.9; ENSP00000337320.4; ENSG00000179195.16.
DR Ensembl; ENST00000392404.7; ENSP00000376205.3; ENSG00000179195.16.
DR Ensembl; ENST00000538932.6; ENSP00000440645.1; ENSG00000179195.16.
DR Ensembl; ENST00000539644.5; ENSP00000441405.1; ENSG00000179195.16.
DR GeneID; 144348; -.
DR KEGG; hsa:144348; -.
DR MANE-Select; ENST00000337815.9; ENSP00000337320.4; NM_152437.3; NP_689650.1.
DR UCSC; uc001uga.4; human.
DR CTD; 144348; -.
DR DisGeNET; 144348; -.
DR GeneCards; ZNF664; -.
DR HGNC; HGNC:25406; ZNF664.
DR HPA; ENSG00000179195; Low tissue specificity.
DR MIM; 617890; gene.
DR neXtProt; NX_Q8N3J9; -.
DR OpenTargets; ENSG00000179195; -.
DR PharmGKB; PA37547; -.
DR VEuPathDB; HostDB:ENSG00000179195; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244829; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; Q8N3J9; -.
DR OMA; ERDRECY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N3J9; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q8N3J9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N3J9; -.
DR BioGRID-ORCS; 144348; 9 hits in 1089 CRISPR screens.
DR ChiTaRS; ZNF664; human.
DR GeneWiki; ZNF664; -.
DR GenomeRNAi; 144348; -.
DR Pharos; Q8N3J9; Tdark.
DR PRO; PR:Q8N3J9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N3J9; protein.
DR Bgee; ENSG00000179195; Expressed in ileal mucosa and 191 other tissues.
DR ExpressionAtlas; Q8N3J9; baseline and differential.
DR Genevisible; Q8N3J9; HS.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..261
FT /note="Zinc finger protein 664"
FT /id="PRO_0000296273"
FT ZN_FING 3..25
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 31..53
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 59..81
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 87..109
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 115..137
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 143..165
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..193
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 199..221
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 227..249
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 257
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CONFLICT 24
FT /note="I -> V (in Ref. 5; AAC41997)"
FT /evidence="ECO:0000305"
FT CONFLICT 113
FT /note="K -> E (in Ref. 5; AAC41997)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="G -> R (in Ref. 4; AAH51696)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="S -> R (in Ref. 5; AAC41997)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="P -> H (in Ref. 4; AAH51696)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 30284 MW; 783FE11E5FBACAA5 CRC64;
MIYKCPMCRE FFSERADLFM HQKIHTAEKP HKCDKCDKGF FHISELHIHW RDHTGEKVYK
CDDCGKDFST TTKLNRHKKI HTVEKPYKCY ECGKAFNWSS HLQIHMRVHT GEKPYVCSEC
GRGFSNSSNL CMHQRVHTGE KPFKCEECGK AFRHTSSLCM HQRVHTGEKP YKCYECGKAF
SQSSSLCIHQ RVHTGEKPYR CCGCGKAFSQ SSSLCIHQRV HTGEKPFKCD ECGKAFSQST
SLCIHQRVHT KERNHLKISV I
