ZN665_HUMAN
ID ZN665_HUMAN Reviewed; 678 AA.
AC Q9H7R5; A8K5T8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-FEB-2019, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Zinc finger protein 665;
DE AltName: Full=Zinc finger protein 160-like;
GN Name=ZNF665; Synonyms=ZFP160L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-84; ARG-157 AND
RP ILE-647.
RC TISSUE=Brain, and Thyroid;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14911.1; Type=Miscellaneous discrepancy; Note=Chimeric sequence.; Evidence={ECO:0000305};
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DR EMBL; AK024407; BAB14911.1; ALT_SEQ; mRNA.
DR EMBL; AK291403; BAF84092.1; -; mRNA.
DR EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46169.1; -.
DR RefSeq; NP_079009.3; NM_024733.3.
DR RefSeq; XP_005259323.1; XM_005259266.4.
DR AlphaFoldDB; Q9H7R5; -.
DR SMR; Q9H7R5; -.
DR BioGRID; 122888; 2.
DR IntAct; Q9H7R5; 3.
DR MINT; Q9H7R5; -.
DR STRING; 9606.ENSP00000379702; -.
DR iPTMnet; Q9H7R5; -.
DR PhosphoSitePlus; Q9H7R5; -.
DR BioMuta; ZNF665; -.
DR DMDM; 325511370; -.
DR EPD; Q9H7R5; -.
DR jPOST; Q9H7R5; -.
DR MassIVE; Q9H7R5; -.
DR MaxQB; Q9H7R5; -.
DR PaxDb; Q9H7R5; -.
DR PeptideAtlas; Q9H7R5; -.
DR PRIDE; Q9H7R5; -.
DR Antibodypedia; 9473; 92 antibodies from 15 providers.
DR DNASU; 79788; -.
DR Ensembl; ENST00000396424.5; ENSP00000379702.2; ENSG00000197497.11.
DR Ensembl; ENST00000650736.1; ENSP00000498600.1; ENSG00000197497.11.
DR GeneID; 79788; -.
DR KEGG; hsa:79788; -.
DR MANE-Select; ENST00000396424.5; ENSP00000379702.2; NM_024733.5; NP_079009.3.
DR UCSC; uc010eqm.2; human.
DR CTD; 79788; -.
DR GeneCards; ZNF665; -.
DR HGNC; HGNC:25885; ZNF665.
DR HPA; ENSG00000197497; Low tissue specificity.
DR neXtProt; NX_Q9H7R5; -.
DR OpenTargets; ENSG00000197497; -.
DR VEuPathDB; HostDB:ENSG00000197497; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162609; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; Q9H7R5; -.
DR OMA; KRPERHF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9H7R5; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q9H7R5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9H7R5; -.
DR BioGRID-ORCS; 79788; 43 hits in 1084 CRISPR screens.
DR ChiTaRS; ZNF665; human.
DR GenomeRNAi; 79788; -.
DR Pharos; Q9H7R5; Tdark.
DR PRO; PR:Q9H7R5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H7R5; protein.
DR Bgee; ENSG00000197497; Expressed in corpus epididymis and 186 other tissues.
DR ExpressionAtlas; Q9H7R5; baseline and differential.
DR Genevisible; Q9H7R5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 18.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..678
FT /note="Zinc finger protein 665"
FT /id="PRO_0000325613"
FT DOMAIN 8..83
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 178..200
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 206..228
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 234..256
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 262..284
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 290..312
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 318..340
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 346..368
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 374..396
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 402..424
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 430..452
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 458..480
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 486..508
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 514..536
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 542..564
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 570..592
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 598..620
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 626..648
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 654..676
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 84
FT /note="V -> A (in dbSNP:rs12460170)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039895"
FT VARIANT 157
FT /note="H -> R (in dbSNP:rs4801959)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039896"
FT VARIANT 647
FT /note="V -> I (in dbSNP:rs4801958)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039897"
FT CONFLICT 419
FT /note="N -> S (in Ref. 1; BAF84092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 678 AA; 77640 MW; 78B5CA3D3744F7B4 CRC64;
MALPQGQLTF KDVAIEFSQE EWTCLDPAQK TLYRDVMLEN YRNLVSLDIS CKCVNTDLPP
KGKNNMGEAF YTVKLERLES CDTVGLSFQE VQKNTYDFEC QWKDDEGNYK TVLMLQKENL
PGRRAQRDRR AAGNRHIENQ LGVSFQSHLP ELQQFQHEGK IYEYNQVEKS PNNRGKHYKC
DECGKVFSQN SRLTSHKRIH TGEKPYQCNK CGKAFTVRSN LTIHQVIHTG EKPYKCNECG
KVFSQPSNLA GHQRIHTGEK PYKCNECGKA FRAHSKLTTH QVIHTGEKPY KCKECGKCFT
QNSHLASHRR IHTGEKPYKC NECGKAFSVR SSLTTHQTIH TGEKPYKCNE CGKVFRHNSY
LAKHRRIHTG EKPYKCNECG KAFSMHSNLT KHQIIHTGEK PFKCNECVKV FTQYSHLANH
RRIHTGEKPY RCDECGKAFS VRSSLTTHQA IHTGEKPYKC NDCGKVFTQN SHLASHRGIH
SGEKPYKCDE CGKAFSQTSQ LARHWRVHTG EKPYKCNECG KAFSVHSSLT IHQTIHTGQK
PYKCNDCGKV FRHNSYLAIH QRIHTGEKPY KCNECGKAFS VHSNLATHQV IHTGEKPYKC
NECGKVFTQN SHLANHRRIH TGEKPYRCNE CGKAFSVRST LTTHMAVHTG DKPYKCNQCG
KVFTQNSNLA KHRRIHSG
