ZN667_HUMAN
ID ZN667_HUMAN Reviewed; 610 AA.
AC Q5HYK9; B2RMS6; B9EK36; Q6B093; Q9H807;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 667;
GN Name=ZNF667;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-134.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-134.
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-134.
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5HYK9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-7115499, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH74898.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH74899.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK024073; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK056508; BAG51734.1; -; mRNA.
DR EMBL; BX647401; CAI46040.1; -; mRNA.
DR EMBL; AC006116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC013256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074898; AAH74898.2; ALT_INIT; mRNA.
DR EMBL; BC074899; AAH74899.2; ALT_INIT; mRNA.
DR EMBL; BC136388; AAI36389.1; -; mRNA.
DR EMBL; BC150593; AAI50594.1; -; mRNA.
DR CCDS; CCDS12944.1; -.
DR RefSeq; NP_001308285.1; NM_001321356.1.
DR RefSeq; NP_071386.3; NM_022103.3.
DR RefSeq; XP_011525510.1; XM_011527208.1.
DR RefSeq; XP_011525511.1; XM_011527209.1.
DR AlphaFoldDB; Q5HYK9; -.
DR SMR; Q5HYK9; -.
DR BioGRID; 122002; 6.
DR IntAct; Q5HYK9; 3.
DR MINT; Q5HYK9; -.
DR STRING; 9606.ENSP00000439402; -.
DR iPTMnet; Q5HYK9; -.
DR PhosphoSitePlus; Q5HYK9; -.
DR BioMuta; ZNF667; -.
DR DMDM; 215273933; -.
DR EPD; Q5HYK9; -.
DR jPOST; Q5HYK9; -.
DR MassIVE; Q5HYK9; -.
DR MaxQB; Q5HYK9; -.
DR PaxDb; Q5HYK9; -.
DR PeptideAtlas; Q5HYK9; -.
DR PRIDE; Q5HYK9; -.
DR ProteomicsDB; 62949; -.
DR Antibodypedia; 33211; 106 antibodies from 20 providers.
DR DNASU; 63934; -.
DR Ensembl; ENST00000292069.10; ENSP00000292069.5; ENSG00000198046.13.
DR Ensembl; ENST00000504904.8; ENSP00000439402.1; ENSG00000198046.13.
DR GeneID; 63934; -.
DR KEGG; hsa:63934; -.
DR MANE-Select; ENST00000504904.8; ENSP00000439402.1; NM_001321356.2; NP_001308285.1.
DR UCSC; uc002qnd.4; human.
DR CTD; 63934; -.
DR DisGeNET; 63934; -.
DR GeneCards; ZNF667; -.
DR HGNC; HGNC:28854; ZNF667.
DR HPA; ENSG00000198046; Tissue enhanced (pituitary).
DR MIM; 611024; gene.
DR neXtProt; NX_Q5HYK9; -.
DR OpenTargets; ENSG00000198046; -.
DR PharmGKB; PA142670514; -.
DR VEuPathDB; HostDB:ENSG00000198046; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00390000021477; -.
DR InParanoid; Q5HYK9; -.
DR OMA; HQNSHSE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5HYK9; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q5HYK9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q5HYK9; -.
DR BioGRID-ORCS; 63934; 11 hits in 1084 CRISPR screens.
DR ChiTaRS; ZNF667; human.
DR GenomeRNAi; 63934; -.
DR Pharos; Q5HYK9; Tbio.
DR PRO; PR:Q5HYK9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q5HYK9; protein.
DR Bgee; ENSG00000198046; Expressed in Brodmann (1909) area 23 and 155 other tissues.
DR ExpressionAtlas; Q5HYK9; baseline and differential.
DR Genevisible; Q5HYK9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..610
FT /note="Zinc finger protein 667"
FT /id="PRO_0000251897"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 144..166
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 172..194
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 415..437
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 443..465
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 471..493
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 499..521
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 527..549
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 555..577
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 583..605
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 119..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 134
FT /note="P -> L (in dbSNP:rs35914474)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_047330"
FT VARIANT 260
FT /note="K -> R (in dbSNP:rs3760849)"
FT /id="VAR_027716"
FT VARIANT 540
FT /note="T -> A (in dbSNP:rs12610019)"
FT /id="VAR_027717"
FT CONFLICT 139
FT /note="S -> P (in Ref. 2; CAI46040)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="A -> T (in Ref. 1; AK024073)"
FT /evidence="ECO:0000305"
FT CONFLICT 593
FT /note="S -> G (in Ref. 1; AK024073 and 2; CAI46040)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 610 AA; 70161 MW; 658048EF4605B884 CRC64;
MPSARGKSKS KAPITFGDLA IYFSQEEWEW LSPIQKDLYE DVMLENYRNL VSLGLSFRRP
NVITLLEKGK APWMVEPVRR RRAPDSGSKC ETKKLPPNQC NKSGQSICQK LVSAQQKAPT
RKSGCNKNSV LVKPKKGHSG KKPLKCNDCG KTFSRSFSLK LHQNIHTGEK PFECSNCRKA
FRQISSILLH QRIHSGKKSH ECNKCGESFN QRTTLILHMR IHDGKEILDC GKALSQCQSF
NIHQKIHVVG NVCQCRKCGK AFNQMSSLLL HKKIHNGKKT HKYNKCGRGF KKKSVFVVHK
RIHAGEKIPE NAKALSQSLQ QRSHHLENPF KCRKCGKLFN RISPLMLHQR IHTSEKPYKC
DKCDKFFRRL STLILHLRIH NGEKLYRCNK CEKVCNRHSS LIQHQKVHTK KKKLFECKEC
GKMFSGTANL KIHQNIHSEE KPFKCNKCSK VFGRQSFLIE HQRIHTGEKP YQCEECGKAF
SHRISLTRHK RIHTEDRPYE CDQCGKAFSQ SAHLAQHERI HTGEKPYTCK TCGKAFSQRT
SLILHERSHT GEKPYECNEC GKAFSSGSDL IRHQRSHSSE KPYECSKCGK AYSRSSSLIR
HQNTHSEEKA
