ZN669_HUMAN
ID ZN669_HUMAN Reviewed; 464 AA.
AC Q96BR6; B3KP94; Q5VT39; Q9H9Q6;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Zinc finger protein 669;
GN Name=ZNF669;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASP-76.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96BR6; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-12006574, EBI-742909;
CC Q96BR6; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-12006574, EBI-11975051;
CC Q96BR6; Q9NP86: CABP5; NbExp=3; IntAct=EBI-12006574, EBI-10311131;
CC Q96BR6; Q86X02: CDR2L; NbExp=3; IntAct=EBI-12006574, EBI-11063830;
CC Q96BR6; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-12006574, EBI-739624;
CC Q96BR6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12006574, EBI-3867333;
CC Q96BR6; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12006574, EBI-5916454;
CC Q96BR6; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-12006574, EBI-3044087;
CC Q96BR6; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-12006574, EBI-11959885;
CC Q96BR6; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-12006574, EBI-12012928;
CC Q96BR6; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12006574, EBI-10171774;
CC Q96BR6; Q99750: MDFI; NbExp=3; IntAct=EBI-12006574, EBI-724076;
CC Q96BR6; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-12006574, EBI-10172526;
CC Q96BR6; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-12006574, EBI-11522433;
CC Q96BR6; Q9UL42: PNMA2; NbExp=3; IntAct=EBI-12006574, EBI-302355;
CC Q96BR6; Q13077: TRAF1; NbExp=3; IntAct=EBI-12006574, EBI-359224;
CC Q96BR6; Q9NQZ6: ZC4H2; NbExp=5; IntAct=EBI-12006574, EBI-747993;
CC Q96BR6; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-12006574, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96BR6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96BR6-2; Sequence=VSP_047204;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK022668; BAB14166.1; -; mRNA.
DR EMBL; AK056020; BAG51606.1; -; mRNA.
DR EMBL; AL627095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015312; AAH15312.1; -; mRNA.
DR CCDS; CCDS31088.1; -. [Q96BR6-1]
DR CCDS; CCDS44345.1; -. [Q96BR6-2]
DR RefSeq; NP_001136044.1; NM_001142572.1. [Q96BR6-2]
DR RefSeq; NP_079080.2; NM_024804.2. [Q96BR6-1]
DR AlphaFoldDB; Q96BR6; -.
DR SMR; Q96BR6; -.
DR BioGRID; 122950; 56.
DR IntAct; Q96BR6; 45.
DR MINT; Q96BR6; -.
DR STRING; 9606.ENSP00000342818; -.
DR iPTMnet; Q96BR6; -.
DR PhosphoSitePlus; Q96BR6; -.
DR BioMuta; ZNF669; -.
DR DMDM; 94730684; -.
DR EPD; Q96BR6; -.
DR jPOST; Q96BR6; -.
DR MassIVE; Q96BR6; -.
DR MaxQB; Q96BR6; -.
DR PaxDb; Q96BR6; -.
DR PeptideAtlas; Q96BR6; -.
DR PRIDE; Q96BR6; -.
DR ProteomicsDB; 3525; -.
DR ProteomicsDB; 76103; -. [Q96BR6-1]
DR Antibodypedia; 34724; 50 antibodies from 14 providers.
DR DNASU; 79862; -.
DR Ensembl; ENST00000343381.10; ENSP00000342818.6; ENSG00000188295.15. [Q96BR6-1]
DR Ensembl; ENST00000448299.7; ENSP00000404370.2; ENSG00000188295.15. [Q96BR6-2]
DR GeneID; 79862; -.
DR KEGG; hsa:79862; -.
DR MANE-Select; ENST00000448299.7; ENSP00000404370.2; NM_001142572.2; NP_001136044.1. [Q96BR6-2]
DR UCSC; uc001ice.3; human. [Q96BR6-1]
DR CTD; 79862; -.
DR GeneCards; ZNF669; -.
DR HGNC; HGNC:25736; ZNF669.
DR HPA; ENSG00000188295; Low tissue specificity.
DR neXtProt; NX_Q96BR6; -.
DR OpenTargets; ENSG00000188295; -.
DR PharmGKB; PA142670516; -.
DR VEuPathDB; HostDB:ENSG00000188295; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164691; -.
DR HOGENOM; CLU_002678_0_10_1; -.
DR InParanoid; Q96BR6; -.
DR OMA; PCREPRA; -.
DR PhylomeDB; Q96BR6; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q96BR6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96BR6; -.
DR BioGRID-ORCS; 79862; 15 hits in 1104 CRISPR screens.
DR ChiTaRS; ZNF669; human.
DR GenomeRNAi; 79862; -.
DR Pharos; Q96BR6; Tdark.
DR PRO; PR:Q96BR6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96BR6; protein.
DR Bgee; ENSG00000188295; Expressed in olfactory bulb and 198 other tissues.
DR ExpressionAtlas; Q96BR6; baseline and differential.
DR Genevisible; Q96BR6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..464
FT /note="Zinc finger protein 669"
FT /id="PRO_0000233988"
FT DOMAIN 90..176
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 189..211
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 222..244
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..272
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 334..356
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 362..384
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 390..412
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 418..440
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..87
FT /note="MVSGLRLASRSGEEGWLKPAVARLGPPRHRLRNLRTESPWRSRGSVLFCSGP
FT GRAGRAAEPLHPVCTCGRHFRRPEPCREPLASPIQ -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047204"
FT VARIANT 76
FT /note="E -> D (in dbSNP:rs4925692)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057439"
FT VARIANT 460
FT /note="G -> S (in dbSNP:rs7533935)"
FT /id="VAR_059928"
FT CONFLICT 204
FT /note="L -> F (in Ref. 1; BAB14166)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="Y -> C (in Ref. 3; AAH15312)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 52597 MW; BAA71F06363F0305 CRC64;
MVSGLRLASR SGEEGWLKPA VARLGPPRHR LRNLRTESPW RSRGSVLFCS GPGRAGRAAE
PLHPVCTCGR HFRRPEPCRE PLASPIQDSV AFEDVAVNFT QEEWALLDSS QKNLYREVMQ
ETCRNLASVG SQWKDQNIED HFEKPGKDIR NHIVQRLCES KEDGQYGEVV SQIPNLDLNE
NISTGLKPCE CSICGKVFVR HSLLNRHILA HSGYKPYGEK QYKCEQCGKF FVSVPGVRRH
MIMHSGNPAY KCTICGKAFY FLNSVERHQR THTGEKPYKC KQCGKAFTVS GSCLIHERTH
TGEKPYECKE CGKTFRFSCS FKTHERTHTG ERPYKCTKCD KAFSCSTSLR YHGSIHTGER
PYECKQCGKA FSRLSSLCNH RSTHTGEKPY ECKQCDQAFS RLSSLHLHER IHTGEKPYEC
KKCGKAYTRS SHLTRHERSH DIEAGCSDSA YNPSTLGGQG VWIA
