ZN670_HUMAN
ID ZN670_HUMAN Reviewed; 389 AA.
AC Q9BS34;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Zinc finger protein 670;
GN Name=ZNF670;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gall bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-281, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
RL Nat. Biotechnol. 23:94-101(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9BS34; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-745276, EBI-11975051;
CC Q9BS34; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-745276, EBI-3866279;
CC Q9BS34; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-745276, EBI-10961312;
CC Q9BS34; O95273: CCNDBP1; NbExp=6; IntAct=EBI-745276, EBI-748961;
CC Q9BS34; P68400: CSNK2A1; NbExp=3; IntAct=EBI-745276, EBI-347804;
CC Q9BS34; P19784: CSNK2A2; NbExp=4; IntAct=EBI-745276, EBI-347451;
CC Q9BS34; O95967: EFEMP2; NbExp=3; IntAct=EBI-745276, EBI-743414;
CC Q9BS34; P28799: GRN; NbExp=3; IntAct=EBI-745276, EBI-747754;
CC Q9BS34; P04792: HSPB1; NbExp=3; IntAct=EBI-745276, EBI-352682;
CC Q9BS34; O60333-2: KIF1B; NbExp=3; IntAct=EBI-745276, EBI-10975473;
CC Q9BS34; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-745276, EBI-10172150;
CC Q9BS34; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-745276, EBI-10172290;
CC Q9BS34; Q99750: MDFI; NbExp=5; IntAct=EBI-745276, EBI-724076;
CC Q9BS34; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-745276, EBI-742948;
CC Q9BS34; Q96CV9: OPTN; NbExp=6; IntAct=EBI-745276, EBI-748974;
CC Q9BS34; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-745276, EBI-396669;
CC Q9BS34; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-745276, EBI-5235340;
CC Q9BS34; O43463: SUV39H1; NbExp=2; IntAct=EBI-745276, EBI-349968;
CC Q9BS34; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-745276, EBI-11955057;
CC Q9BS34; Q8WV44: TRIM41; NbExp=6; IntAct=EBI-745276, EBI-725997;
CC Q9BS34; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-745276, EBI-744794;
CC Q9BS34; O76024: WFS1; NbExp=3; IntAct=EBI-745276, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK074774; BAC11200.1; -; mRNA.
DR EMBL; AL512637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005360; AAH05360.1; -; mRNA.
DR CCDS; CCDS31087.1; -.
DR RefSeq; NP_149990.1; NM_033213.4.
DR AlphaFoldDB; Q9BS34; -.
DR SMR; Q9BS34; -.
DR BioGRID; 125029; 25.
DR IntAct; Q9BS34; 28.
DR MINT; Q9BS34; -.
DR STRING; 9606.ENSP00000355459; -.
DR iPTMnet; Q9BS34; -.
DR PhosphoSitePlus; Q9BS34; -.
DR BioMuta; ZNF670; -.
DR DMDM; 74761228; -.
DR EPD; Q9BS34; -.
DR jPOST; Q9BS34; -.
DR MassIVE; Q9BS34; -.
DR MaxQB; Q9BS34; -.
DR PaxDb; Q9BS34; -.
DR PeptideAtlas; Q9BS34; -.
DR PRIDE; Q9BS34; -.
DR ProteomicsDB; 78863; -.
DR Antibodypedia; 74455; 103 antibodies from 16 providers.
DR DNASU; 93474; -.
DR Ensembl; ENST00000366503.3; ENSP00000355459.2; ENSG00000277462.2.
DR GeneID; 93474; -.
DR KEGG; hsa:93474; -.
DR MANE-Select; ENST00000366503.3; ENSP00000355459.2; NM_033213.5; NP_149990.1.
DR UCSC; uc001icd.3; human.
DR CTD; 93474; -.
DR GeneCards; ZNF670; -.
DR HGNC; HGNC:28167; ZNF670.
DR HPA; ENSG00000277462; Low tissue specificity.
DR neXtProt; NX_Q9BS34; -.
DR OpenTargets; ENSG00000277462; -.
DR PharmGKB; PA142670517; -.
DR VEuPathDB; HostDB:ENSG00000277462; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164696; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q9BS34; -.
DR OMA; CPEKLYH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9BS34; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q9BS34; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9BS34; -.
DR BioGRID-ORCS; 93474; 15 hits in 1092 CRISPR screens.
DR GenomeRNAi; 93474; -.
DR Pharos; Q9BS34; Tdark.
DR PRO; PR:Q9BS34; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BS34; protein.
DR Bgee; ENSG00000277462; Expressed in cortical plate and 123 other tissues.
DR Genevisible; Q9BS34; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0044255; P:cellular lipid metabolic process; IDA:MGI.
DR GO; GO:0006629; P:lipid metabolic process; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..389
FT /note="Zinc finger protein 670"
FT /id="PRO_0000233989"
FT DOMAIN 4..90
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 103..125
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 141..163
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 9; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 281
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:15592455"
SQ SEQUENCE 389 AA; 44603 MW; E0828F813293C098 CRC64;
MDSVSFEDVA VAFTQEEWAL LDPSQKNLYR DVMQEIFRNL ASVGNKSEDQ NIQDDFKNPG
RNLSSHVVER LFEIKEGSQY GETFSQDSNL NLNKKVSTGV KPCECSVCGK VFICHSALHR
HILSHIGNKL FECEECPEKL YHCKQCGKAF ISLTSVDRHM VTHTSNGPYK GPVYEKPFDF
PSVFQMPQST YTGEKTYKCK HCDKAFNYSS YLREHERTHT GEKPYACKKC GKSFTFSSSL
RQHERSHTGE KPYECKECGK AFSRSTYLGI HERTHTGEKP YECIKCGKAF RCSRVLRVHE
RTHSGEKPYE CKQCGKAFKY SSNLCEHERT HTGVKPYGCK ECGKSFTSSS ALRSHERTHT
GEKPYECKKC GKAFSCSSSL RKHERAYMW
