ZN671_HUMAN
ID ZN671_HUMAN Reviewed; 534 AA.
AC Q8TAW3; A6NF07; Q9H5E9;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 671;
GN Name=ZNF671;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-149.
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH25728.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK027159; BAB15677.1; -; mRNA.
DR EMBL; AC003006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72529.1; -; Genomic_DNA.
DR EMBL; BC025728; AAH25728.1; ALT_FRAME; mRNA.
DR CCDS; CCDS12961.1; -.
DR RefSeq; NP_079109.2; NM_024833.2.
DR AlphaFoldDB; Q8TAW3; -.
DR SMR; Q8TAW3; -.
DR BioGRID; 122975; 3.
DR IntAct; Q8TAW3; 1.
DR MINT; Q8TAW3; -.
DR STRING; 9606.ENSP00000321848; -.
DR iPTMnet; Q8TAW3; -.
DR PhosphoSitePlus; Q8TAW3; -.
DR BioMuta; ZNF671; -.
DR DMDM; 229462791; -.
DR MassIVE; Q8TAW3; -.
DR MaxQB; Q8TAW3; -.
DR PaxDb; Q8TAW3; -.
DR PeptideAtlas; Q8TAW3; -.
DR PRIDE; Q8TAW3; -.
DR ProteomicsDB; 73931; -.
DR Antibodypedia; 33287; 94 antibodies from 22 providers.
DR DNASU; 79891; -.
DR Ensembl; ENST00000317398.10; ENSP00000321848.5; ENSG00000083814.13.
DR GeneID; 79891; -.
DR KEGG; hsa:79891; -.
DR MANE-Select; ENST00000317398.10; ENSP00000321848.5; NM_024833.3; NP_079109.2.
DR UCSC; uc002qpz.5; human.
DR CTD; 79891; -.
DR DisGeNET; 79891; -.
DR GeneCards; ZNF671; -.
DR HGNC; HGNC:26279; ZNF671.
DR HPA; ENSG00000083814; Low tissue specificity.
DR neXtProt; NX_Q8TAW3; -.
DR OpenTargets; ENSG00000083814; -.
DR PharmGKB; PA142670518; -.
DR VEuPathDB; HostDB:ENSG00000083814; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163659; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q8TAW3; -.
DR OMA; RPGCWHG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TAW3; -.
DR TreeFam; TF342033; -.
DR PathwayCommons; Q8TAW3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TAW3; -.
DR BioGRID-ORCS; 79891; 12 hits in 1102 CRISPR screens.
DR ChiTaRS; ZNF671; human.
DR GenomeRNAi; 79891; -.
DR Pharos; Q8TAW3; Tbio.
DR PRO; PR:Q8TAW3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TAW3; protein.
DR Bgee; ENSG00000083814; Expressed in cerebellar hemisphere and 116 other tissues.
DR ExpressionAtlas; Q8TAW3; baseline and differential.
DR Genevisible; Q8TAW3; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..534
FT /note="Zinc finger protein 671"
FT /id="PRO_0000233990"
FT DOMAIN 49..120
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 192..214
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..501
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 507..529
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 149
FT /note="A -> V (in dbSNP:rs3746207)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026151"
FT VARIANT 237
FT /note="P -> S (in dbSNP:rs34419645)"
FT /id="VAR_055240"
SQ SEQUENCE 534 AA; 60972 MW; 701BC2C02BC95124 CRC64;
MLSPVSRDAS DALQGRKCLR PRSRRLPLPA AVRAHGPMAE LTDSARGCVV FEDVFVYFSR
EEWELLDDAQ RLLYHDVMLE NFALLASLGI AFSRSRAVMK LERGEEPWVY DQVDMTSATE
REAQRGLRPG CWHGVEDEEV SSEQSIFVAG VSEVRTLMAE LESHPCDICG PILKDTLHLA
KYHGGKARQK PYLCGACGKQ FWFSTDFDQH QNQPNGGKLF PRKEGRDSVK SCRVHVPEKT
LTCGKGRRDF SATSGLLQHQ ASLSSMKPHK STKLVSGFLM GQRYHRCGEC GKAFTRKDTL
ARHQRIHTGE RPYECNECGK FFSQSYDLFK HQTVHTGERP YECSECGKFF RQISGLIEHR
RVHTGERLYQ CGKCGKFFSS KSNLIRHQEV HTGARPYVCS ECGKEFSRKH TLVLHQRTHT
GERPYECSEC GKAFSQSSHL NVHWRIHSSD YECSRCGKAF SCISKLIQHQ KVHSGEKPYE
CSKCGKAFTQ RPNLIRHWKV HTGERPYVCS ECGREFIRKQ TLVLHQRVHA GEKL
