ZN672_HUMAN
ID ZN672_HUMAN Reviewed; 452 AA.
AC Q499Z4; Q96H65; Q96IM3; Q9H6G5;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Zinc finger protein 672 {ECO:0000305};
GN Name=ZNF672 {ECO:0000312|HGNC:HGNC:26179};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Epithelium, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lymph, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q499Z4; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-12146251, EBI-12012928;
CC Q499Z4; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-12146251, EBI-14065470;
CC Q499Z4; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-12146251, EBI-22310682;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH08872.1; Type=Miscellaneous discrepancy; Note=Non-canonical splice intron-exon junction.; Evidence={ECO:0000305};
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DR EMBL; AK025954; BAB15294.1; -; mRNA.
DR EMBL; AK027679; BAB55290.1; -; mRNA.
DR EMBL; BC007385; AAH07385.2; -; mRNA.
DR EMBL; BC008872; AAH08872.1; ALT_SEQ; mRNA.
DR EMBL; BC035140; AAH35140.1; -; mRNA.
DR EMBL; BC050348; AAH50348.1; -; mRNA.
DR EMBL; BC068506; AAH68506.1; -; mRNA.
DR CCDS; CCDS1638.1; -.
DR RefSeq; NP_079112.1; NM_024836.2.
DR RefSeq; XP_005270393.1; XM_005270336.1.
DR AlphaFoldDB; Q499Z4; -.
DR SMR; Q499Z4; -.
DR BioGRID; 122978; 11.
DR IntAct; Q499Z4; 4.
DR STRING; 9606.ENSP00000421915; -.
DR iPTMnet; Q499Z4; -.
DR PhosphoSitePlus; Q499Z4; -.
DR BioMuta; ZNF672; -.
DR DMDM; 116242864; -.
DR EPD; Q499Z4; -.
DR jPOST; Q499Z4; -.
DR MassIVE; Q499Z4; -.
DR MaxQB; Q499Z4; -.
DR PaxDb; Q499Z4; -.
DR PeptideAtlas; Q499Z4; -.
DR PRIDE; Q499Z4; -.
DR Antibodypedia; 34768; 119 antibodies from 19 providers.
DR DNASU; 79894; -.
DR Ensembl; ENST00000306562.8; ENSP00000421915.1; ENSG00000171161.13.
DR GeneID; 79894; -.
DR KEGG; hsa:79894; -.
DR MANE-Select; ENST00000306562.8; ENSP00000421915.1; NM_024836.3; NP_079112.1.
DR UCSC; uc001iex.4; human.
DR CTD; 79894; -.
DR GeneCards; ZNF672; -.
DR HGNC; HGNC:26179; ZNF672.
DR HPA; ENSG00000171161; Low tissue specificity.
DR neXtProt; NX_Q499Z4; -.
DR OpenTargets; ENSG00000171161; -.
DR PharmGKB; PA142670473; -.
DR VEuPathDB; HostDB:ENSG00000171161; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244873; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q499Z4; -.
DR OMA; DAHQCGV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q499Z4; -.
DR TreeFam; TF337999; -.
DR PathwayCommons; Q499Z4; -.
DR SignaLink; Q499Z4; -.
DR BioGRID-ORCS; 79894; 9 hits in 1102 CRISPR screens.
DR ChiTaRS; ZNF672; human.
DR GenomeRNAi; 79894; -.
DR Pharos; Q499Z4; Tdark.
DR PRO; PR:Q499Z4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q499Z4; protein.
DR Bgee; ENSG00000171161; Expressed in hindlimb stylopod muscle and 188 other tissues.
DR ExpressionAtlas; Q499Z4; baseline and differential.
DR Genevisible; Q499Z4; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..452
FT /note="Zinc finger protein 672"
FT /id="PRO_0000233991"
FT ZN_FING 14..36
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 42..64
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 70..92
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 99..122
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 128..150
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 163..185
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 199..221
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 227..249
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..277
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 283..305
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..333
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..417
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 182
FT /note="A -> P (in Ref. 2; AAH50348/AAH35140)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 452 AA; 50224 MW; 4D9D8B262748A39E CRC64;
MFATSGAVAA GKPYSCSECG KSFCYSSVLL RHERAHGGDG RFRCLECGER CARAADLRAH
RRTHAGQTLY ICSECGQSFR HSGRLDLHLG AHRQRCRTCP CRTCGRRFPH LPALLLHRRR
QHLPERPRRC PLCARTFRQS ALLFHQARAH PLGTTSDPAA PPHRCAQCPR AFRSGAGLRS
HARIHVSRSP TRPRVSDAHQ CGVCGKCFGK SSTLTRHLQT HSGEKPFKCP ECGKGFLESA
TLVRHQRTHT GEKPYACGDC GRCFSESSTL LRHRRSHQGE RPHACATCGK GFGQRSDLVV
HQRIHTGEKP FACPECGRRF SDRSDLTKHR RTHTGEKPYR CELCGKRFTC VSNLNVHRRN
HAGHKPHKCP ECSKAFSVAS KLALHRKTHL GERPAECAEC GKCFSHSRSL SQHQRAHTRA
RTAAAVAIQS AVGTALVFEG PAEQEKPGFS VS
