ZN672_MOUSE
ID ZN672_MOUSE Reviewed; 468 AA.
AC Q99LH4; Q8BIR7;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein 672;
GN Name=Znf672; Synonyms=Zfp672;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Lung, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK029711; BAC26575.1; -; mRNA.
DR EMBL; AK035113; BAC28948.1; -; mRNA.
DR EMBL; AK085166; BAC39380.1; -; mRNA.
DR EMBL; AL845463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003258; AAH03258.1; -; mRNA.
DR EMBL; BC034706; AAH34706.1; -; mRNA.
DR CCDS; CCDS24727.1; -.
DR RefSeq; NP_001243445.1; NM_001256516.1.
DR RefSeq; NP_001243446.1; NM_001256517.1.
DR RefSeq; NP_001243447.1; NM_001256518.1.
DR RefSeq; NP_001243448.1; NM_001256519.1.
DR RefSeq; NP_001243449.1; NM_001256520.1.
DR RefSeq; NP_848876.2; NM_178761.5.
DR RefSeq; XP_006533583.1; XM_006533520.3.
DR RefSeq; XP_011247371.1; XM_011249069.2.
DR RefSeq; XP_017170079.1; XM_017314590.1.
DR RefSeq; XP_017170080.1; XM_017314591.1.
DR AlphaFoldDB; Q99LH4; -.
DR SMR; Q99LH4; -.
DR STRING; 10090.ENSMUSP00000104457; -.
DR PhosphoSitePlus; Q99LH4; -.
DR EPD; Q99LH4; -.
DR MaxQB; Q99LH4; -.
DR PaxDb; Q99LH4; -.
DR PeptideAtlas; Q99LH4; -.
DR PRIDE; Q99LH4; -.
DR ProteomicsDB; 302139; -.
DR Antibodypedia; 34768; 119 antibodies from 19 providers.
DR DNASU; 319475; -.
DR Ensembl; ENSMUST00000057836; ENSMUSP00000060088; ENSMUSG00000049755.
DR Ensembl; ENSMUST00000064786; ENSMUSP00000070567; ENSMUSG00000049755.
DR Ensembl; ENSMUST00000108829; ENSMUSP00000104457; ENSMUSG00000049755.
DR GeneID; 319475; -.
DR KEGG; mmu:319475; -.
DR UCSC; uc007jaz.2; mouse.
DR CTD; 319475; -.
DR MGI; MGI:2442105; Zfp672.
DR VEuPathDB; HostDB:ENSMUSG00000049755; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244873; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q99LH4; -.
DR OMA; DAHQCGV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q99LH4; -.
DR TreeFam; TF337999; -.
DR BioGRID-ORCS; 319475; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Zfp672; mouse.
DR PRO; PR:Q99LH4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99LH4; protein.
DR Bgee; ENSMUSG00000049755; Expressed in spermatocyte and 251 other tissues.
DR ExpressionAtlas; Q99LH4; baseline and differential.
DR Genevisible; Q99LH4; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..468
FT /note="Zinc finger protein 672"
FT /id="PRO_0000233992"
FT ZN_FING 15..37
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 43..65
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 71..93
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 100..123
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 129..151
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 167..189
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 202..224
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..252
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..308
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 306
FT /note="R -> H (in Ref. 1; BAC26575)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 468 AA; 52154 MW; 110623DEE3A39C1D CRC64;
MFTAPGMATT QERPYSCSVC GKSFQYSAVL LRHERAHGGD KRFCCLECGE RCARAADLRA
HRWTHAGQTL YICSECGQSF SHSGLLDLHL GTHRRRSRTR PCRLCGRRFP HVPALLLHRA
RQHPPEKPHR CPLCARSFRQ SALPFHLARA HPPEIITVTA PSPSTLYHCT QCPRAFHSSA
GLRNHSRIHV VPSLSDPGTE AHLCGICGKS FSKSSTLTRH LQRHSGEKPF KCPECGKGFL
ESATLVRHQR THTGEKPYAC SDCGRCFSES STLLRHQRSH QGERPHVCAT CGKGFGQRYD
LVVHQRSHTG ERPFPCPQCG RGFTDRSDLT KHLRTHTGEK PYHCELCGKR FTCISNLNVH
LRNHAGHKPH KCPECGKSFS VASKLALHRK THLGERTAEC TECGKFFSHG RSLSQHQRSH
RRARAAAMAA TTTTTVVTEV TIGPSLTLTG PTEQEKSGLL VSPFQETC
