ZN676_HUMAN
ID ZN676_HUMAN Reviewed; 588 AA.
AC Q8N7Q3; A8MVX5;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Zinc finger protein 676;
GN Name=ZNF676;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-588.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC073539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK097798; BAC05174.1; -; mRNA.
DR CCDS; CCDS42539.1; -.
DR RefSeq; NP_001001411.2; NM_001001411.2.
DR AlphaFoldDB; Q8N7Q3; -.
DR SMR; Q8N7Q3; -.
DR BioGRID; 127857; 1.
DR IntAct; Q8N7Q3; 1.
DR STRING; 9606.ENSP00000380310; -.
DR iPTMnet; Q8N7Q3; -.
DR PhosphoSitePlus; Q8N7Q3; -.
DR BioMuta; ZNF676; -.
DR DMDM; 215273918; -.
DR EPD; Q8N7Q3; -.
DR jPOST; Q8N7Q3; -.
DR MassIVE; Q8N7Q3; -.
DR MaxQB; Q8N7Q3; -.
DR PaxDb; Q8N7Q3; -.
DR PeptideAtlas; Q8N7Q3; -.
DR PRIDE; Q8N7Q3; -.
DR ProteomicsDB; 72318; -.
DR Antibodypedia; 44182; 33 antibodies from 10 providers.
DR DNASU; 163223; -.
DR Ensembl; ENST00000395385.7; ENSP00000378783.4; ENSG00000276219.4.
DR Ensembl; ENST00000397121.3; ENSP00000380310.1; ENSG00000196109.9.
DR GeneID; 163223; -.
DR KEGG; hsa:163223; -.
DR MANE-Select; ENST00000397121.3; ENSP00000380310.1; NM_001001411.3; NP_001001411.2.
DR UCSC; uc002nqs.2; human.
DR CTD; 163223; -.
DR DisGeNET; 163223; -.
DR GeneCards; ZNF676; -.
DR HGNC; HGNC:20429; ZNF676.
DR HPA; ENSG00000196109; Low tissue specificity.
DR neXtProt; NX_Q8N7Q3; -.
DR OpenTargets; ENSG00000196109; -.
DR PharmGKB; PA142670477; -.
DR VEuPathDB; HostDB:ENSG00000196109; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q8N7Q3; -.
DR OMA; FAQNIHL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N7Q3; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q8N7Q3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N7Q3; -.
DR BioGRID-ORCS; 163223; 293 hits in 1017 CRISPR screens.
DR GenomeRNAi; 163223; -.
DR Pharos; Q8N7Q3; Tdark.
DR PRO; PR:Q8N7Q3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N7Q3; protein.
DR Bgee; ENSG00000196109; Expressed in thyroid gland and 90 other tissues.
DR ExpressionAtlas; Q8N7Q3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..588
FT /note="Zinc finger protein 676"
FT /id="PRO_0000233996"
FT DOMAIN 1..43
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 169..191
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 561..583
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 27
FT /note="G -> E (in dbSNP:rs8104929)"
FT /id="VAR_047437"
FT VARIANT 96
FT /note="E -> K (in dbSNP:rs12986319)"
FT /id="VAR_047438"
FT VARIANT 292
FT /note="S -> W (in dbSNP:rs11671538)"
FT /id="VAR_047439"
FT CONFLICT 180
FT /note="W -> S (in Ref. 2; BAC05174)"
FT /evidence="ECO:0000305"
FT CONFLICT 183..190
FT /note="TLTYYKSI -> NLMEHKRV (in Ref. 2; BAC05174)"
FT /evidence="ECO:0000305"
FT CONFLICT 208..220
FT /note="KFSILTKHKVIHT -> WSSSLTEHKRIHA (in Ref. 2;
FT BAC05174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 588 AA; 67624 MW; 662E28DBE1CBB6D6 CRC64;
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS QEFWPEQGIE
DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK LNQSLTTTQS KVFQCGKYAN
VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF CMLSHLSQHE RIYTRENSYK CEENGKAFNW
SSTLTYYKSI HTGEKPYKCE ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL
TKHKIIHTGE KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS ILTKHKIIHT
GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK ASNSSSKLME HKRIHTGEKP
YKCEECGKAF SWSSSLTEHK RIHAGEKPYK CEECGKAFTW SSSFTKHKRI HAAEKPYKCE
ECGKGFSTFS ILTKHKIIHT GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK
AFSRSSSLTR HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP
