ID   ZN677_HUMAN             Reviewed;         584 AA.
AC   Q86XU0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Zinc finger protein 677;
GN   Name=ZNF677;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC050038; AAH50038.1; -; mRNA.
DR   CCDS; CCDS12861.1; -.
DR   RefSeq; NP_001304927.1; NM_001317998.1.
DR   RefSeq; NP_872415.1; NM_182609.3.
DR   RefSeq; XP_011525214.1; XM_011526912.2.
DR   AlphaFoldDB; Q86XU0; -.
DR   SMR; Q86XU0; -.
DR   BioGRID; 131210; 27.
DR   IntAct; Q86XU0; 2.
DR   STRING; 9606.ENSP00000469391; -.
DR   iPTMnet; Q86XU0; -.
DR   PhosphoSitePlus; Q86XU0; -.
DR   BioMuta; ZNF677; -.
DR   DMDM; 74759507; -.
DR   EPD; Q86XU0; -.
DR   jPOST; Q86XU0; -.
DR   MassIVE; Q86XU0; -.
DR   MaxQB; Q86XU0; -.
DR   PaxDb; Q86XU0; -.
DR   PeptideAtlas; Q86XU0; -.
DR   PRIDE; Q86XU0; -.
DR   ProteomicsDB; 70334; -.
DR   Antibodypedia; 19160; 79 antibodies from 18 providers.
DR   DNASU; 342926; -.
DR   Ensembl; ENST00000333952.8; ENSP00000334394.4; ENSG00000197928.11.
DR   Ensembl; ENST00000598513.6; ENSP00000469391.1; ENSG00000197928.11.
DR   GeneID; 342926; -.
DR   KEGG; hsa:342926; -.
DR   MANE-Select; ENST00000598513.6; ENSP00000469391.1; NM_182609.4; NP_872415.1.
DR   UCSC; uc002qbg.2; human.
DR   CTD; 342926; -.
DR   DisGeNET; 342926; -.
DR   GeneCards; ZNF677; -.
DR   HGNC; HGNC:28730; ZNF677.
DR   HPA; ENSG00000197928; Tissue enhanced (testis).
DR   neXtProt; NX_Q86XU0; -.
DR   OpenTargets; ENSG00000197928; -.
DR   PharmGKB; PA142670478; -.
DR   VEuPathDB; HostDB:ENSG00000197928; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000160770; -.
DR   HOGENOM; CLU_002678_0_2_1; -.
DR   InParanoid; Q86XU0; -.
DR   OMA; WENMSKF; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q86XU0; -.
DR   TreeFam; TF341892; -.
DR   PathwayCommons; Q86XU0; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q86XU0; -.
DR   BioGRID-ORCS; 342926; 8 hits in 1095 CRISPR screens.
DR   ChiTaRS; ZNF677; human.
DR   GenomeRNAi; 342926; -.
DR   Pharos; Q86XU0; Tdark.
DR   PRO; PR:Q86XU0; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q86XU0; protein.
DR   Bgee; ENSG00000197928; Expressed in secondary oocyte and 174 other tissues.
DR   ExpressionAtlas; Q86XU0; baseline and differential.
DR   Genevisible; Q86XU0; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 6.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..584
FT                   /note="Zinc finger protein 677"
FT                   /id="PRO_0000233997"
FT   DOMAIN          8..90
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         263..285
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         291..313
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         319..341
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         347..369
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         375..397
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         403..425
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         431..453
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         459..481
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         487..509
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         515..537
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         56
FT                   /note="D -> N (in dbSNP:rs11881131)"
FT                   /id="VAR_052889"
FT   VARIANT         254
FT                   /note="G -> E (in dbSNP:rs10425706)"
FT                   /id="VAR_052890"
SQ   SEQUENCE   584 AA;  67996 MW;  F111E49F528CB29F CRC64;
     MALSQGLFTF KDVAIEFSQE EWECLDPAQR ALYRDVMLEN YRNLLSLDED NIPPEDDISV
     GFTSKGLSPK ENNKEELYHL VILERKESHG INNFDLKEVW ENMPKFDSLW DYDVKNYKGM
     PLTCNKNLTH RKDQQHNKSS IHFSLKQSVS IRDSAHQYFI HDKPFIRNLL KLKNNIRYAG
     NKYVKCFENK IGLSLQAQLA ELQRFQTGEK MYECNPVEKS INSSSVSPLP PCVKNICNKY
     RKILKYPLLH TQYGRTHIRE KSYKCNDCGK AFSKSSNLTN HQRIHSGQRP YKCNECGKAF
     NQCSNLTRHQ RVHTGEKPYQ CNICGKVCSQ NSNLASHQRM HTGEKPYKCN ECGKAFIQRS
     HLWGHERIHT GEKPYKCNEC DKAFAERSSL TQHKRIHTGE KPYICNECGK AFKQCSHLTR
     HQNIHPGEKP HKCNVCGRAF IQSSSLVEHQ RIHTGEKPYK CNKCDKAFIK RSHLWGHQRT
     HTGEKPYKCT ECGKAFTERS NLTQHKKIHT GEKPYKCTEC GKAFTQFANL TRHQKIHIEK
     KHCKHNIHGN ALFQSSNLGD HQKSYNREKH IKYNETKIKY SSCT