ZN678_HUMAN
ID ZN678_HUMAN Reviewed; 525 AA.
AC Q5SXM1; Q8IVQ9;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Zinc finger protein 678;
GN Name=ZNF678;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-144.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AL592310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042500; AAH42500.1; -; mRNA.
DR AlphaFoldDB; Q5SXM1; -.
DR SMR; Q5SXM1; -.
DR IntAct; Q5SXM1; 2.
DR STRING; 9606.ENSP00000344828; -.
DR iPTMnet; Q5SXM1; -.
DR PhosphoSitePlus; Q5SXM1; -.
DR BioMuta; ZNF678; -.
DR DMDM; 74756138; -.
DR EPD; Q5SXM1; -.
DR jPOST; Q5SXM1; -.
DR MassIVE; Q5SXM1; -.
DR PaxDb; Q5SXM1; -.
DR PeptideAtlas; Q5SXM1; -.
DR PRIDE; Q5SXM1; -.
DR Antibodypedia; 34656; 76 antibodies from 12 providers.
DR Ensembl; ENST00000343776.10; ENSP00000344828.4; ENSG00000181450.18.
DR Ensembl; ENST00000397097.4; ENSP00000440403.2; ENSG00000181450.18.
DR MANE-Select; ENST00000343776.10; ENSP00000344828.4; NM_001367909.1; NP_001354838.1.
DR UCSC; uc001hqw.3; human.
DR GeneCards; ZNF678; -.
DR HGNC; HGNC:28652; ZNF678.
DR HPA; ENSG00000181450; Low tissue specificity.
DR neXtProt; NX_Q5SXM1; -.
DR OpenTargets; ENSG00000181450; -.
DR VEuPathDB; HostDB:ENSG00000181450; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154251; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q5SXM1; -.
DR OMA; STHNSMN; -.
DR PhylomeDB; Q5SXM1; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q5SXM1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q5SXM1; -.
DR ChiTaRS; ZNF678; human.
DR Pharos; Q5SXM1; Tdark.
DR PRO; PR:Q5SXM1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SXM1; protein.
DR Bgee; ENSG00000181450; Expressed in buccal mucosa cell and 178 other tissues.
DR ExpressionAtlas; Q5SXM1; baseline and differential.
DR Genevisible; Q5SXM1; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..525
FT /note="Zinc finger protein 678"
FT /id="PRO_0000233998"
FT ZN_FING 97..119
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 125..147
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 153..175
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 181..203
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 209..231
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 293..315
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..399
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 405..427
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 433..455
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..483
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 489..511
FT /note="C2H2-type 15; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 144
FT /note="K -> E (in dbSNP:rs17854209)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026154"
FT VARIANT 152
FT /note="P -> T (in dbSNP:rs61283390)"
FT /id="VAR_061962"
FT VARIANT 197
FT /note="T -> I (in dbSNP:rs12118505)"
FT /id="VAR_057441"
SQ SEQUENCE 525 AA; 61411 MW; 23FD2180FF0F0152 CRC64;
MGTISLCIGV CAFEGANTST SFYKLVYTAI LSYSIQDLLP EQDMKDLCQK VTLTRHRSWG
LDNLHLVKDW RTVNEGKGQK EYCNRLTQCS STKSKIFQCI ECGRNFSWRS ILTEHKRIHT
GEKPYKCEEC GKVFNRCSNL TKHKRIHTGE KPYKCDECGK VFNWWSQLTN HKKIHTGEKP
YKCDECDKVF NWWSQLTSHK KIHSGEKPYP CEECGKAFTQ FSNLTQHKRI HTGEKPYKCK
ECCKAFNKFS NLTQHKRIHT GEKPYKCEEC GNVFNECSHL TRHRRIHTGE KPYKCEECGK
AFTQFASLTR HKRIHTGEKP YQCEECGKTF NRCSHLSSHK RIHTGEKPYK CEECGRTFTQ
FSNLTQHKRI HTGEKPYKCK ECGKAFNKFS SLTQHRRIHT GVKPYKCEEC GKVFKQCSHL
TSHKRIHTGE KPYKCKECGK AFYQSSILSK HKRIHTEEKP YKCEECGKAF NQFSSLTRHK
RIHTGEKRYK CKECGKGFYQ SSIHSKYKRI YTGEEPDKCK KCGSL
