ZN679_HUMAN
ID ZN679_HUMAN Reviewed; 411 AA.
AC Q8IYX0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 679;
GN Name=ZNF679;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IYX0; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-745567, EBI-10172150;
CC Q8IYX0; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-745567, EBI-12012928;
CC Q8IYX0; Q9BS40: LXN; NbExp=3; IntAct=EBI-745567, EBI-1044504;
CC Q8IYX0; Q99750: MDFI; NbExp=4; IntAct=EBI-745567, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC073270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC033523; AAH33523.1; -; mRNA.
DR CCDS; CCDS47592.1; -.
DR RefSeq; NP_699194.2; NM_153363.2.
DR RefSeq; XP_016867286.1; XM_017011797.1.
DR AlphaFoldDB; Q8IYX0; -.
DR SMR; Q8IYX0; -.
DR BioGRID; 127961; 6.
DR IntAct; Q8IYX0; 5.
DR STRING; 9606.ENSP00000416809; -.
DR iPTMnet; Q8IYX0; -.
DR PhosphoSitePlus; Q8IYX0; -.
DR BioMuta; ZNF679; -.
DR DMDM; 296453054; -.
DR jPOST; Q8IYX0; -.
DR MassIVE; Q8IYX0; -.
DR MaxQB; Q8IYX0; -.
DR PaxDb; Q8IYX0; -.
DR PeptideAtlas; Q8IYX0; -.
DR PRIDE; Q8IYX0; -.
DR ProteomicsDB; 71254; -.
DR Antibodypedia; 72015; 39 antibodies from 8 providers.
DR DNASU; 168417; -.
DR Ensembl; ENST00000255746.7; ENSP00000255746.4; ENSG00000197123.9.
DR Ensembl; ENST00000421025.3; ENSP00000416809.1; ENSG00000197123.9.
DR GeneID; 168417; -.
DR KEGG; hsa:168417; -.
DR MANE-Select; ENST00000421025.3; ENSP00000416809.1; NM_153363.3; NP_699194.2.
DR UCSC; uc003tsx.3; human.
DR CTD; 168417; -.
DR DisGeNET; 168417; -.
DR GeneCards; ZNF679; -.
DR HGNC; HGNC:28650; ZNF679.
DR HPA; ENSG00000197123; Tissue enriched (testis).
DR neXtProt; NX_Q8IYX0; -.
DR OpenTargets; ENSG00000197123; -.
DR PharmGKB; PA142670480; -.
DR VEuPathDB; HostDB:ENSG00000197123; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153236; -.
DR HOGENOM; CLU_002678_44_17_1; -.
DR InParanoid; Q8IYX0; -.
DR OMA; HKTRHSG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IYX0; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q8IYX0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8IYX0; -.
DR BioGRID-ORCS; 168417; 14 hits in 1050 CRISPR screens.
DR ChiTaRS; ZNF679; human.
DR GenomeRNAi; 168417; -.
DR Pharos; Q8IYX0; Tdark.
DR PRO; PR:Q8IYX0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IYX0; protein.
DR Bgee; ENSG00000197123; Expressed in right testis and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..411
FT /note="Zinc finger protein 679"
FT /id="PRO_0000233999"
FT DOMAIN 16..87
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 156..178
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 69
FT /note="E -> G (in dbSNP:rs12154540)"
FT /id="VAR_033586"
FT VARIANT 120
FT /note="H -> R (in dbSNP:rs17139320)"
FT /id="VAR_033587"
FT VARIANT 212
FT /note="Y -> H (in dbSNP:rs1830035)"
FT /id="VAR_033588"
FT VARIANT 223
FT /note="C -> S (in dbSNP:rs1830036)"
FT /id="VAR_033589"
FT CONFLICT 328
FT /note="E -> K (in Ref. 2; AAH33523)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 411 AA; 47179 MW; C687350A4A2BCBC0 CRC64;
MAKRPGSPGS REMGLLTFRD VVIEFSLEEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS
KPDLITCLEQ NKEPWNIKRN EMVTKHPVMC SHFTQDLPPE LGIKDSLQKV IPRRYGKSGH
DNLQVKTCKS MGECEVQKGG CNEVNQCLST TQNKIFQTHK CVKVFGKFSN SNRHKTRHTG
KKHFKCKKYG KSFCMVSQLH QHQIIHTREN SYQCEECGKP FNCSSTLSKH KRIHTGEKPY
RCEECGKAFT WSSTLTKHRR IHTGEKPYTC EECGQAFSRS STLANHKRIH TGEKPYTCEE
CGKAFSLSSS LTYHKRIHTG EKPYTCEECG KAFNCSSTLK KHKIIHTGEK PYKCKECGKA
FAFSSTLNTH KRIHTGEEPY KCEECDKAFK WSSSLANHKS MHTGEKPYKC E
