ZN684_HUMAN
ID ZN684_HUMAN Reviewed; 378 AA.
AC Q5T5D7; Q2NKY4;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 684;
GN Name=ZNF684;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AL356379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC091518; AAH91518.1; -; mRNA.
DR EMBL; BC111463; AAI11464.1; -; mRNA.
DR CCDS; CCDS454.1; -.
DR RefSeq; NP_689586.3; NM_152373.3.
DR RefSeq; XP_011538973.1; XM_011540671.2.
DR RefSeq; XP_011538974.1; XM_011540672.2.
DR RefSeq; XP_011538975.1; XM_011540673.2.
DR RefSeq; XP_016855779.1; XM_017000290.1.
DR AlphaFoldDB; Q5T5D7; -.
DR SMR; Q5T5D7; -.
DR BioGRID; 126056; 15.
DR IntAct; Q5T5D7; 1.
DR STRING; 9606.ENSP00000361784; -.
DR iPTMnet; Q5T5D7; -.
DR PhosphoSitePlus; Q5T5D7; -.
DR BioMuta; ZNF684; -.
DR DMDM; 74756332; -.
DR EPD; Q5T5D7; -.
DR jPOST; Q5T5D7; -.
DR MassIVE; Q5T5D7; -.
DR PaxDb; Q5T5D7; -.
DR PeptideAtlas; Q5T5D7; -.
DR PRIDE; Q5T5D7; -.
DR ProteomicsDB; 64513; -.
DR Antibodypedia; 32104; 35 antibodies from 13 providers.
DR DNASU; 127396; -.
DR Ensembl; ENST00000372699.8; ENSP00000361784.3; ENSG00000117010.17.
DR Ensembl; ENST00000648542.1; ENSP00000497154.1; ENSG00000117010.17.
DR GeneID; 127396; -.
DR KEGG; hsa:127396; -.
DR MANE-Select; ENST00000372699.8; ENSP00000361784.3; NM_152373.4; NP_689586.3.
DR UCSC; uc001cft.2; human.
DR CTD; 127396; -.
DR GeneCards; ZNF684; -.
DR HGNC; HGNC:28418; ZNF684.
DR HPA; ENSG00000117010; Low tissue specificity.
DR neXtProt; NX_Q5T5D7; -.
DR OpenTargets; ENSG00000117010; -.
DR PharmGKB; PA142670485; -.
DR VEuPathDB; HostDB:ENSG00000117010; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163099; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q5T5D7; -.
DR OMA; DCPLIDE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5T5D7; -.
DR TreeFam; TF337898; -.
DR PathwayCommons; Q5T5D7; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q5T5D7; -.
DR BioGRID-ORCS; 127396; 19 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF684; human.
DR GenomeRNAi; 127396; -.
DR Pharos; Q5T5D7; Tdark.
DR PRO; PR:Q5T5D7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T5D7; protein.
DR Bgee; ENSG00000117010; Expressed in right lobe of liver and 121 other tissues.
DR ExpressionAtlas; Q5T5D7; baseline and differential.
DR Genevisible; Q5T5D7; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..378
FT /note="Zinc finger protein 684"
FT /id="PRO_0000234003"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 159..181
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 187..209
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 215..237
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 378 AA; 43945 MW; 47AD3D8DE2A8B613 CRC64;
MISFQESVTF QDVAVDFTAE EWQLLDCAER TLYWDVMLEN YRNLISVGCP ITKTKVILKV
EQGQEPWMVE GANPHESSPE SDYPLVDEPG KHRESKDNFL KSVLLTFNKI LTMERIHHYN
MSTSLNPMRK KSYKSFEKCL PPNLDLLKYN RSYTVENAYE CSECGKAFKK KFHFIRHEKN
HTRKKPFECN DCGKAYSRKA HLATHQKIHN GERPFVCNDC GKAFMHKAQL VVHQRLHTGE
KPYECSQCGK TFTWNSSFNQ HVKSHTLEKS FECKECGKTF RYSSSLYKHS RFHTGEKPYQ
CIICGKAFGN TSVLVTHQRI HTGEKPYSCI ECGKAFIKKS HLLRHQITHT GEKPYECNRC
GKAFSQKSNL IVHQKIHT
