CCA21_ARATH
ID CCA21_ARATH Reviewed; 443 AA.
AC Q39071; F4JWR7; Q9ZU09;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 3.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Cyclin-A2-1;
DE AltName: Full=Cyc3a-At;
DE AltName: Full=Cyclin-3a;
DE AltName: Full=G2/mitotic-specific cyclin-A2-1;
DE Short=CycA2;1;
GN Name=CYCA2-1; Synonyms=CYC3A; OrderedLocusNames=At5g25380;
GN ORFNames=F18G18.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=7972055; DOI=10.1073/pnas.91.24.11313;
RA Ferreira P., Hemerly A., de Almeida Engler J., Bergounioux C., Burssens S.,
RA van Montagu M., Engler G., Inze D.;
RT "Three discrete classes of Arabidopsis cyclins are expressed during
RT different intervals of the cell cycle.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:11313-11317(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=11089674; DOI=10.1007/s004250000333;
RA Burssens S., de Almeida Engler J., Beeckman T., Richard C., Shaul O.,
RA Ferreira P.C.G., van Montagu M., Inze D.;
RT "Developmental expression of the Arabidopsis thaliana CycA2;1 gene.";
RL Planta 211:623-631(2000).
RN [5]
RP INDUCTION.
RX PubMed=11089675; DOI=10.1007/s004250000334;
RA Burssens S., Himanen K., van de Cotte B., Beeckman T., van Montagu M.,
RA Inze D., Verbruggen N.;
RT "Expression of cell cycle regulatory genes and morphological alterations in
RT response to salt stress in Arabidopsis thaliana.";
RL Planta 211:632-640(2000).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [7]
RP FUNCTION.
RX PubMed=17012601; DOI=10.1105/tpc.106.043869;
RA Yoshizumi T., Tsumoto Y., Takiguchi T., Nagata N., Yamamoto Y.Y.,
RA Kawashima M., Ichikawa T., Nakazawa M., Yamamoto N., Matsui M.;
RT "Increased level of polyploidy1, a conserved repressor of CYCLINA2
RT transcription, controls endoreduplication in Arabidopsis.";
RL Plant Cell 18:2452-2468(2006).
CC -!- FUNCTION: May negatively regulate endocycles and act as a regulator of
CC ploidy levels in endoreduplication. {ECO:0000269|PubMed:17012601}.
CC -!- TISSUE SPECIFICITY: Expressed in tissues with active cell division:
CC apical root and shoot meristems, lateral root and leaf primordia,
CC floral meristems and developing pollen. {ECO:0000269|PubMed:11089674,
CC ECO:0000269|PubMed:7972055}.
CC -!- DEVELOPMENTAL STAGE: Starts to be expressed during S phase with a
CC maximum just before the G2-to-M boundary and disappears in the
CC metaphase of mitosis. Expressed during embryogenesis in the ovule,
CC integuments, egg cell and synergids, and in the embryo up to late-
CC torpedo stage. Expressed during germination in the root apical
CC meristem, shoot apical meristem, vascular bundles of the cotyledons and
CC vascular cylinder of the roots up to lateral roots emergence. Expressed
CC during flowering in the caulines leaves, peduncle, sepals of flower
CC buds, early expanded petals, ovary, placenta, funiculi, devoloping
CC ovules, pollen connective tissues, tapetum, endothecium, epidermis and
CC developing pollen grains. {ECO:0000269|PubMed:11089674}.
CC -!- INDUCTION: By auxin in the roots, cytokinin in the shoot apex and
CC sucrose in suspension cell culture. Down-regulated by salt stress in
CC root meristem and shoot apex. {ECO:0000269|PubMed:11089674,
CC ECO:0000269|PubMed:11089675}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AED93433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; Z31589; CAA83460.1; -; Genomic_DNA.
DR EMBL; AC006258; AAC98445.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93433.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; ANM70898.1; -; Genomic_DNA.
DR RefSeq; NP_001318646.1; NM_001343923.1.
DR RefSeq; NP_001332473.1; NM_001343925.1.
DR RefSeq; NP_197920.2; NM_122447.3.
DR AlphaFoldDB; Q39071; -.
DR SMR; Q39071; -.
DR BioGRID; 17885; 12.
DR IntAct; Q39071; 5.
DR STRING; 3702.AT5G25380.1; -.
DR PaxDb; Q39071; -.
DR PRIDE; Q39071; -.
DR EnsemblPlants; AT5G25380.4; AT5G25380.4; AT5G25380.
DR GeneID; 832610; -.
DR Gramene; AT5G25380.4; AT5G25380.4; AT5G25380.
DR KEGG; ath:AT5G25380; -.
DR Araport; AT5G25380; -.
DR eggNOG; KOG0654; Eukaryota.
DR HOGENOM; CLU_020695_13_3_1; -.
DR InParanoid; Q39071; -.
DR OrthoDB; 993640at2759; -.
DR PRO; PR:Q39071; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q39071; baseline and differential.
DR Genevisible; Q39071; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cyclin; Reference proteome.
FT CHAIN 1..443
FT /note="Cyclin-A2-1"
FT /id="PRO_0000286993"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 97
FT /note="K -> RQ (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 144..145
FT /note="QK -> E (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="V -> L (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="Q -> R (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="I -> V (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 381
FT /note="Q -> K (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 397
FT /note="T -> A (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 403
FT /note="E -> D (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
FT CONFLICT 417
FT /note="H -> R (in Ref. 1; CAA83460)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 443 AA; 50336 MW; A4A8D9707F7A13A5 CRC64;
MHRASSKHTN AKKEAISTSK IRDNNVRVTR SRAKALGVSN SPSKPAFKHE TKRVARPSNK
RMASDNITVC NQKRRAVLKD VTNTLAESII STEGNVKACK RGGKETKQIE EDGLVDVDGE
KSKLAEDLSK IRMVESLDAS ASKQKLVDCA EEDRSDVTDC VQIVDIDSGV QDPQFCSLYA
ASIYDSINVA ELEQRPSTSY MVQVQRDIDP TMRGILIDWL VEVSEEYKLV SDTLYLTVNL
IDRFMSHNYI EKQKLQLLGI TCMLIASKYE EISAPRLEEF CFITDNTYTR LEVLSMEIKV
LNSLHFRLSV PTTKTFLRRF IRAAQASDKV PLIEMEYLAN YFAELTLTEY TFLRFLPSLI
AASAVFLARW TLDQSNHPWN QTLQHYTRYE TSALKNTVLA MEELQLNTSG STLIAIHTKY
NQQKFKRVAT LTSPERVNTL FSR
