ZN688_HUMAN
ID ZN688_HUMAN Reviewed; 276 AA.
AC P0C7X2; A8MV39; B3KV51; O75701; Q8IW91; Q8WV14; Q96MN0;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Zinc finger protein 688;
GN Name=ZNF688;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=B-cell, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-215 (ISOFORM 2).
RG The MGC Project Team;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P0C7X2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-4395732, EBI-11096309;
CC P0C7X2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-4395732, EBI-17183751;
CC P0C7X2; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-4395732, EBI-12006120;
CC P0C7X2; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-4395732, EBI-8643161;
CC P0C7X2; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-4395732, EBI-11530605;
CC P0C7X2; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-4395732, EBI-744545;
CC P0C7X2; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-4395732, EBI-10171570;
CC P0C7X2; P24863: CCNC; NbExp=3; IntAct=EBI-4395732, EBI-395261;
CC P0C7X2; P55273: CDKN2D; NbExp=3; IntAct=EBI-4395732, EBI-745859;
CC P0C7X2; Q86X02: CDR2L; NbExp=3; IntAct=EBI-4395732, EBI-11063830;
CC P0C7X2; Q96Q77: CIB3; NbExp=3; IntAct=EBI-4395732, EBI-10292696;
CC P0C7X2; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-4395732, EBI-745369;
CC P0C7X2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-4395732, EBI-6658203;
CC P0C7X2; P55040: GEM; NbExp=3; IntAct=EBI-4395732, EBI-744104;
CC P0C7X2; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-4395732, EBI-748515;
CC P0C7X2; O95872: GPANK1; NbExp=3; IntAct=EBI-4395732, EBI-751540;
CC P0C7X2; P49639: HOXA1; NbExp=3; IntAct=EBI-4395732, EBI-740785;
CC P0C7X2; O75031: HSF2BP; NbExp=3; IntAct=EBI-4395732, EBI-7116203;
CC P0C7X2; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-4395732, EBI-11955401;
CC P0C7X2; P25800: LMO1; NbExp=3; IntAct=EBI-4395732, EBI-8639312;
CC P0C7X2; P25791-3: LMO2; NbExp=3; IntAct=EBI-4395732, EBI-11959475;
CC P0C7X2; Q13064: MKRN3; NbExp=3; IntAct=EBI-4395732, EBI-2340269;
CC P0C7X2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-4395732, EBI-5662487;
CC P0C7X2; O43639: NCK2; NbExp=3; IntAct=EBI-4395732, EBI-713635;
CC P0C7X2; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-4395732, EBI-11750983;
CC P0C7X2; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-4395732, EBI-725252;
CC P0C7X2; P16118: PFKFB1; NbExp=3; IntAct=EBI-4395732, EBI-709807;
CC P0C7X2; O43189: PHF1; NbExp=3; IntAct=EBI-4395732, EBI-530034;
CC P0C7X2; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-4395732, EBI-10232538;
CC P0C7X2; O15160: POLR1C; NbExp=3; IntAct=EBI-4395732, EBI-1055079;
CC P0C7X2; P20618: PSMB1; NbExp=3; IntAct=EBI-4395732, EBI-372273;
CC P0C7X2; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-4395732, EBI-1504830;
CC P0C7X2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-4395732, EBI-748391;
CC P0C7X2; Q12824-2: SMARCB1; NbExp=3; IntAct=EBI-4395732, EBI-358436;
CC P0C7X2; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-4395732, EBI-11955057;
CC P0C7X2; Q8WWU5-7: TCP11; NbExp=3; IntAct=EBI-4395732, EBI-17721485;
CC P0C7X2; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-4395732, EBI-750487;
CC P0C7X2; Q96A09: TENT5B; NbExp=3; IntAct=EBI-4395732, EBI-752030;
CC P0C7X2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-4395732, EBI-11741437;
CC P0C7X2; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-4395732, EBI-948354;
CC P0C7X2; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-4395732, EBI-10183064;
CC P0C7X2; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-4395732, EBI-373456;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0C7X2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0C7X2-5; Sequence=VSP_046955;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: ZNF688 and ZNF785.; Evidence={ECO:0000305};
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DR EMBL; AK122680; BAG53663.1; -; mRNA.
DR EMBL; AC002310; AAC31673.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471192; EAW52233.1; -; Genomic_DNA.
DR EMBL; CH471192; EAW52235.1; -; Genomic_DNA.
DR EMBL; BC018997; AAH18997.1; -; mRNA.
DR EMBL; BM011208; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS10684.1; -. [P0C7X2-1]
DR CCDS; CCDS42151.1; -. [P0C7X2-5]
DR RefSeq; NP_001019854.1; NM_001024683.1. [P0C7X2-5]
DR RefSeq; NP_660314.1; NM_145271.3. [P0C7X2-1]
DR AlphaFoldDB; P0C7X2; -.
DR SMR; P0C7X2; -.
DR BioGRID; 126996; 113.
DR IntAct; P0C7X2; 45.
DR STRING; 9606.ENSP00000223459; -.
DR iPTMnet; P0C7X2; -.
DR PhosphoSitePlus; P0C7X2; -.
DR BioMuta; ZNF688; -.
DR DMDM; 205636136; -.
DR MassIVE; P0C7X2; -.
DR MaxQB; P0C7X2; -.
DR PaxDb; P0C7X2; -.
DR PeptideAtlas; P0C7X2; -.
DR PRIDE; P0C7X2; -.
DR ProteomicsDB; 2151; -.
DR ProteomicsDB; 52386; -. [P0C7X2-1]
DR Antibodypedia; 27350; 158 antibodies from 19 providers.
DR DNASU; 146542; -.
DR Ensembl; ENST00000223459.11; ENSP00000223459.6; ENSG00000229809.9. [P0C7X2-1]
DR Ensembl; ENST00000563276.5; ENSP00000455227.2; ENSG00000229809.9. [P0C7X2-5]
DR GeneID; 146542; -.
DR KEGG; hsa:146542; -.
DR MANE-Select; ENST00000223459.11; ENSP00000223459.6; NM_145271.4; NP_660314.1.
DR UCSC; uc002dyt.4; human. [P0C7X2-1]
DR CTD; 146542; -.
DR DisGeNET; 146542; -.
DR GeneCards; ZNF688; -.
DR HGNC; HGNC:30489; ZNF688.
DR HPA; ENSG00000229809; Low tissue specificity.
DR neXtProt; NX_P0C7X2; -.
DR OpenTargets; ENSG00000229809; -.
DR PharmGKB; PA142670487; -.
DR VEuPathDB; HostDB:ENSG00000229809; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162549; -.
DR HOGENOM; CLU_002678_13_2_1; -.
DR InParanoid; P0C7X2; -.
DR OMA; WMEQENE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P0C7X2; -.
DR TreeFam; TF339643; -.
DR PathwayCommons; P0C7X2; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P0C7X2; -.
DR BioGRID-ORCS; 146542; 7 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF688; human.
DR GenomeRNAi; 146542; -.
DR Pharos; P0C7X2; Tdark.
DR PRO; PR:P0C7X2; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P0C7X2; protein.
DR Bgee; ENSG00000229809; Expressed in sural nerve and 190 other tissues.
DR ExpressionAtlas; P0C7X2; baseline and differential.
DR Genevisible; P0C7X2; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..276
FT /note="Zinc finger protein 688"
FT /id="PRO_0000234007"
FT DOMAIN 26..97
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 183..205
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 211..233
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..65
FT /note="MAPPPAPLLAPRPGETRPGCRKPGTVSFADVAVYFSPEEWGCLRPAQRALYR
FT DVMQETYGHLGAL -> MPRSPLRSSLSTEASGPRGPFKCPASPRPITAQLLPGSSPII
FT GRCVLRVQR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_046955"
FT VARIANT 131
FT /note="S -> I (in dbSNP:rs33997546)"
FT /id="VAR_052896"
FT CONFLICT 153
FT /note="P -> A (in Ref. 5; BM011208)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="T -> S (in Ref. 5; BM011208)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 30575 MW; 11D583A6D671CBFE CRC64;
MAPPPAPLLA PRPGETRPGC RKPGTVSFAD VAVYFSPEEW GCLRPAQRAL YRDVMQETYG
HLGALGFPGP KPALISWMEQ ESEAWSPAAQ DPEKGERLGG ARRGDVPNRK EEEPEEVPRA
KGPRKAPVKE SPEVLVERNP DPAISVAPAR AQPPKNAAWD PTTGAQPPAP IPSMDAQAGQ
RRHVCTDCGR RFTYPSLLVS HRRMHSGERP FPCPECGMRF KRKFAVEAHQ WIHRSCSGGR
RGRRPGIRAV PRAPVRGDRD PPVLFRHYPD IFEECG
