ZN695_HUMAN
ID ZN695_HUMAN Reviewed; 515 AA.
AC Q8IW36; Q5T0N9; Q5T0P1; Q5T0P3; Q7Z2W8; Q7Z648;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 4.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 695;
DE AltName: Full=Zinc finger protein SBZF3;
GN Name=ZNF695;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANTS
RP LYS-84 AND ALA-87.
RC TISSUE=Leiomyosarcoma, and Lung carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IW36; P50222: MEOX2; NbExp=3; IntAct=EBI-10261951, EBI-748397;
CC Q8IW36-1; Q96JY6: PDLIM2; NbExp=3; IntAct=EBI-18985109, EBI-9057264;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=4;
CC IsoId=Q8IW36-4; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8IW36-1; Sequence=VSP_038548, VSP_038549;
CC Name=2;
CC IsoId=Q8IW36-2; Sequence=VSP_018108, VSP_018109;
CC Name=3;
CC IsoId=Q8IW36-3; Sequence=VSP_018106, VSP_018107;
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DR EMBL; AC113174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL512637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC023527; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC041082; AAH41082.2; -; mRNA.
DR EMBL; BC055096; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44344.1; -. [Q8IW36-4]
DR CCDS; CCDS55694.1; -. [Q8IW36-1]
DR RefSeq; NP_001191150.1; NM_001204221.1. [Q8IW36-1]
DR AlphaFoldDB; Q8IW36; -.
DR SMR; Q8IW36; -.
DR BioGRID; 121380; 24.
DR IntAct; Q8IW36; 13.
DR STRING; 9606.ENSP00000341236; -.
DR iPTMnet; Q8IW36; -.
DR PhosphoSitePlus; Q8IW36; -.
DR BioMuta; ZNF695; -.
DR DMDM; 284018174; -.
DR EPD; Q8IW36; -.
DR jPOST; Q8IW36; -.
DR MassIVE; Q8IW36; -.
DR MaxQB; Q8IW36; -.
DR PaxDb; Q8IW36; -.
DR PeptideAtlas; Q8IW36; -.
DR PRIDE; Q8IW36; -.
DR ProteomicsDB; 70800; -. [Q8IW36-4]
DR ProteomicsDB; 70801; -. [Q8IW36-1]
DR ProteomicsDB; 70802; -. [Q8IW36-2]
DR ProteomicsDB; 70803; -. [Q8IW36-3]
DR Antibodypedia; 11896; 155 antibodies from 26 providers.
DR DNASU; 57116; -.
DR Ensembl; ENST00000339986.8; ENSP00000341236.7; ENSG00000197472.15. [Q8IW36-4]
DR Ensembl; ENST00000366504.6; ENSP00000355460.2; ENSG00000197472.15. [Q8IW36-2]
DR Ensembl; ENST00000487338.6; ENSP00000429736.1; ENSG00000197472.15. [Q8IW36-1]
DR GeneID; 57116; -.
DR KEGG; hsa:57116; -.
DR MANE-Select; ENST00000339986.8; ENSP00000341236.7; NM_020394.5; NP_065127.5.
DR UCSC; uc001ibx.4; human. [Q8IW36-4]
DR CTD; 57116; -.
DR DisGeNET; 57116; -.
DR GeneCards; ZNF695; -.
DR HGNC; HGNC:30954; ZNF695.
DR HPA; ENSG00000197472; Not detected.
DR MIM; 616348; gene.
DR neXtProt; NX_Q8IW36; -.
DR OpenTargets; ENSG00000197472; -.
DR PharmGKB; PA142670493; -.
DR VEuPathDB; HostDB:ENSG00000197472; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154251; -.
DR HOGENOM; CLU_002678_69_5_1; -.
DR InParanoid; Q8IW36; -.
DR OMA; FTDYKRI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IW36; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q8IW36; -.
DR SignaLink; Q8IW36; -.
DR BioGRID-ORCS; 57116; 7 hits in 1092 CRISPR screens.
DR GenomeRNAi; 57116; -.
DR Pharos; Q8IW36; Tdark.
DR PRO; PR:Q8IW36; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8IW36; protein.
DR Bgee; ENSG00000197472; Expressed in ganglionic eminence and 89 other tissues.
DR ExpressionAtlas; Q8IW36; baseline and differential.
DR Genevisible; Q8IW36; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..515
FT /note="Zinc finger protein 695"
FT /id="PRO_0000233282"
FT DOMAIN 4..87
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 156..178
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 88
FT /note="L -> M (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018106"
FT VAR_SEQ 89..515
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018107"
FT VAR_SEQ 131..172
FT /note="VGEWKGQKASYNGLDLCSATTHSKNFQCNKCVKGFSKFANLN -> PCEDVL
FT ASPLPSAMILSFLRPPQKQKHVKPTEPVQSSTIELL (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038548"
FT VAR_SEQ 132..133
FT /note="GE -> AM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018108"
FT VAR_SEQ 134..515
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018109"
FT VAR_SEQ 173..515
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038549"
FT VARIANT 84
FT /note="R -> K (in dbSNP:rs2642973)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057446"
FT VARIANT 87
FT /note="V -> A (in dbSNP:rs2642992)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057447"
FT VARIANT 110
FT /note="M -> I (in dbSNP:rs55762230)"
FT /id="VAR_061963"
SQ SEQUENCE 515 AA; 60149 MW; B37EA43D0B16E8B5 CRC64;
MGLLAFRDVA LEFSPEEWEC LDPAQRSLYR DVMLENYRNL ISLGEDSFNM QFLFHSLAMS
KPELIICLEA RKEPWNVNTE KTARHSVLSS YLTEDILPEQ GLQVSFQKVM LRRYERCCLE
KLRLRNDWEI VGEWKGQKAS YNGLDLCSAT THSKNFQCNK CVKGFSKFAN LNKCKISHTG
EKPFKCKECG NVSCMSLIMT QQQRIHIGEN PYQCKKCGKA FNECSCFTDC KRIHVGEKHC
KCEECNNIFK SCSSLAVVEK NHTEKKTYRC EECGKAFNLC SVLTKHKKIH TGEKPYKCEE
CGKSFKLFPY LTQHKRIHSR EKPYKCEECG KVFKLLSYLT QHRRIHTGEK TFRCEECGKA
FNQSSHLTEH RRIHTGEKPY KCEECGKAFT WFSYLIQHKR IHTGQKPYKC EECGKAFTWF
SYLTQHKRIH TGEKPYKCDE CGKAFNWFSY LTNHKRIHTG EKPYKCEECG KAFGQSSHLS
KHKTIHTREK PYKCEECGKA FNHSAQLAVH EKTHT
