ZN696_HUMAN
ID ZN696_HUMAN Reviewed; 374 AA.
AC Q9H7X3; A0AVE2;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Zinc finger protein 696;
GN Name=ZNF696;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9H7X3; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-11090299, EBI-739580;
CC Q9H7X3; O95273: CCNDBP1; NbExp=3; IntAct=EBI-11090299, EBI-748961;
CC Q9H7X3; O60729: CDC14B; NbExp=3; IntAct=EBI-11090299, EBI-970231;
CC Q9H7X3; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-11090299, EBI-739624;
CC Q9H7X3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11090299, EBI-3867333;
CC Q9H7X3; Q92997: DVL3; NbExp=3; IntAct=EBI-11090299, EBI-739789;
CC Q9H7X3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11090299, EBI-5916454;
CC Q9H7X3; P28799: GRN; NbExp=3; IntAct=EBI-11090299, EBI-747754;
CC Q9H7X3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11090299, EBI-11959885;
CC Q9H7X3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11090299, EBI-11749135;
CC Q9H7X3; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11090299, EBI-10172150;
CC Q9H7X3; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11090299, EBI-12012928;
CC Q9H7X3; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-11090299, EBI-10172290;
CC Q9H7X3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11090299, EBI-10171774;
CC Q9H7X3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11090299, EBI-10172052;
CC Q9H7X3; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11090299, EBI-10176379;
CC Q9H7X3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11090299, EBI-11953334;
CC Q9H7X3; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11090299, EBI-11988175;
CC Q9H7X3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-11090299, EBI-739863;
CC Q9H7X3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11090299, EBI-3958099;
CC Q9H7X3; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11090299, EBI-1044640;
CC Q9H7X3; Q99750: MDFI; NbExp=3; IntAct=EBI-11090299, EBI-724076;
CC Q9H7X3; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11090299, EBI-10172526;
CC Q9H7X3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11090299, EBI-11522433;
CC Q9H7X3; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-11090299, EBI-9640281;
CC Q9H7X3; P78317: RNF4; NbExp=5; IntAct=EBI-11090299, EBI-2340927;
CC Q9H7X3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-11090299, EBI-5235340;
CC Q9H7X3; Q16623: STX1A; NbExp=3; IntAct=EBI-11090299, EBI-712466;
CC Q9H7X3; Q6N022: TENM4; NbExp=3; IntAct=EBI-11090299, EBI-12827077;
CC Q9H7X3; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-11090299, EBI-725997;
CC Q9H7X3; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11090299, EBI-11957238;
CC Q9H7X3; O76024: WFS1; NbExp=3; IntAct=EBI-11090299, EBI-720609;
CC Q9H7X3; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11090299, EBI-11035148;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK024191; BAB14850.1; -; mRNA.
DR EMBL; CH471162; EAW82267.1; -; Genomic_DNA.
DR EMBL; BC126317; AAI26318.1; -; mRNA.
DR CCDS; CCDS6399.1; -.
DR RefSeq; NP_112157.2; NM_030895.2.
DR AlphaFoldDB; Q9H7X3; -.
DR SMR; Q9H7X3; -.
DR BioGRID; 123015; 69.
DR IntAct; Q9H7X3; 46.
DR STRING; 9606.ENSP00000328515; -.
DR iPTMnet; Q9H7X3; -.
DR PhosphoSitePlus; Q9H7X3; -.
DR BioMuta; ZNF696; -.
DR DMDM; 212276484; -.
DR EPD; Q9H7X3; -.
DR jPOST; Q9H7X3; -.
DR MassIVE; Q9H7X3; -.
DR MaxQB; Q9H7X3; -.
DR PaxDb; Q9H7X3; -.
DR PeptideAtlas; Q9H7X3; -.
DR PRIDE; Q9H7X3; -.
DR ProteomicsDB; 81154; -.
DR Antibodypedia; 27868; 95 antibodies from 18 providers.
DR DNASU; 79943; -.
DR Ensembl; ENST00000330143.8; ENSP00000328515.3; ENSG00000185730.8.
DR GeneID; 79943; -.
DR KEGG; hsa:79943; -.
DR MANE-Select; ENST00000330143.8; ENSP00000328515.3; NM_030895.3; NP_112157.2.
DR UCSC; uc003yxy.5; human.
DR CTD; 79943; -.
DR GeneCards; ZNF696; -.
DR HGNC; HGNC:25872; ZNF696.
DR HPA; ENSG00000185730; Low tissue specificity.
DR neXtProt; NX_Q9H7X3; -.
DR OpenTargets; ENSG00000185730; -.
DR PharmGKB; PA142670494; -.
DR VEuPathDB; HostDB:ENSG00000185730; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163493; -.
DR HOGENOM; CLU_002678_3_0_1; -.
DR InParanoid; Q9H7X3; -.
DR OMA; CGLSFKC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9H7X3; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q9H7X3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9H7X3; -.
DR BioGRID-ORCS; 79943; 23 hits in 1101 CRISPR screens.
DR ChiTaRS; ZNF696; human.
DR GenomeRNAi; 79943; -.
DR Pharos; Q9H7X3; Tdark.
DR PRO; PR:Q9H7X3; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9H7X3; protein.
DR Bgee; ENSG00000185730; Expressed in tendon of biceps brachii and 155 other tissues.
DR ExpressionAtlas; Q9H7X3; baseline and differential.
DR Genevisible; Q9H7X3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..374
FT /note="Zinc finger protein 696"
FT /id="PRO_0000233278"
FT ZN_FING 125..147
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 153..175
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 181..203
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 209..231
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 293..315
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 30..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 312
FT /note="R -> C (in Ref. 1; BAB14850)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 40575 MW; 68AE7E35A33FD6FE CRC64;
MEPGGEPTGA KESSTLMESL AAVKAAFLAQ APSGSRSAEV QAAQSTEPAA EAGAPEGEGH
RGGPPRALGS LGLCENQEAR ERPGGSPRGP VTSEKTGGQS GLESDVPPNA GPGAEGGGSW
KGRPFPCGAC GRSFKCSSDA AKHRSIHSGE KPYECSDCGK AFIHSSHVVR HQRAHSGERP
YACAECGKAF GQSFNLLRHQ RVHTGEKPYA CADCGKAFGQ RSDAAKHRRT HTGERLYACG
ECGKRFLHSS NVVRHRRTHH GENPYECREC GQAFSQSSNL LQHQRVHTGE RPFACQDCGR
AFSRSSFLRE HRRIHTGEKP HQCGHCGRAF RALSGFFRHQ RLHTGEKPFR CTECGRAFRL
SFHLIQHRRV HGAE
