ZN700_HUMAN
ID ZN700_HUMAN Reviewed; 742 AA.
AC Q9H0M5; B9EGU4;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 700;
GN Name=ZNF700;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AL136732; CAB66666.1; -; mRNA.
DR EMBL; CH471106; EAW84251.1; -; Genomic_DNA.
DR EMBL; BC136777; AAI36778.1; -; mRNA.
DR CCDS; CCDS32915.1; -.
DR RefSeq; NP_001258777.1; NM_001271848.1.
DR RefSeq; NP_653167.1; NM_144566.2.
DR AlphaFoldDB; Q9H0M5; -.
DR SMR; Q9H0M5; -.
DR IntAct; Q9H0M5; 1.
DR STRING; 9606.ENSP00000479449; -.
DR iPTMnet; Q9H0M5; -.
DR PhosphoSitePlus; Q9H0M5; -.
DR BioMuta; ZNF700; -.
DR DMDM; 74761386; -.
DR jPOST; Q9H0M5; -.
DR MassIVE; Q9H0M5; -.
DR MaxQB; Q9H0M5; -.
DR PaxDb; Q9H0M5; -.
DR PeptideAtlas; Q9H0M5; -.
DR PRIDE; Q9H0M5; -.
DR ProteomicsDB; 80302; -.
DR Antibodypedia; 25970; 23 antibodies from 11 providers.
DR DNASU; 90592; -.
DR Ensembl; ENST00000254321.10; ENSP00000254321.4; ENSG00000196757.8.
DR GeneID; 90592; -.
DR KEGG; hsa:90592; -.
DR MANE-Select; ENST00000254321.10; ENSP00000254321.4; NM_144566.3; NP_653167.1.
DR UCSC; uc002msu.5; human.
DR CTD; 90592; -.
DR GeneCards; ZNF700; -.
DR HGNC; HGNC:25292; ZNF700.
DR HPA; ENSG00000196757; Low tissue specificity.
DR neXtProt; NX_Q9H0M5; -.
DR OpenTargets; ENSG00000196757; -.
DR PharmGKB; PA142670497; -.
DR VEuPathDB; HostDB:ENSG00000196757; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q9H0M5; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9H0M5; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q9H0M5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9H0M5; -.
DR BioGRID-ORCS; 90592; 8 hits in 1089 CRISPR screens.
DR GenomeRNAi; 90592; -.
DR Pharos; Q9H0M5; Tdark.
DR PRO; PR:Q9H0M5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H0M5; protein.
DR Bgee; ENSG00000196757; Expressed in granulocyte and 94 other tissues.
DR ExpressionAtlas; Q9H0M5; baseline and differential.
DR Genevisible; Q9H0M5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 21.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..742
FT /note="Zinc finger protein 700"
FT /id="PRO_0000233280"
FT DOMAIN 24..104
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 194..216
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 222..244
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..272
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 362..384
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 390..412
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 418..440
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..502
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..530
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 592..614
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 620..642
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 648..670
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 676..698
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 704..726
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 269
FT /note="E -> G (in dbSNP:rs12327617)"
FT /id="VAR_052897"
FT VARIANT 321
FT /note="L -> V (in dbSNP:rs17001730)"
FT /id="VAR_033591"
SQ SEQUENCE 742 AA; 86232 MW; 99EA4FE63E7D12DC CRC64;
MPCCSHRSCR EDPGTSESRE MDPVAFEDVA VNFTQEEWTL LDISQKNLFR EVMLETFRNL
TSIGKKWSDQ NIEYEYQNPR RSFRSLIEEK VNEIKEDSHC GETFTQVPDD RLNFQEKKAS
PEVKSCDSFV CAEVGIGNSS FNMSIRGDTG HKAYEYQEYG PKPYKCQQPK NKKAFRYRPS
IRTQERDHTG EKPYACKVCG KTFIFHSSIR RHMVMHSGDG TYKCKFCGKA FHSFSLYLIH
ERTHTGEKPY ECKQCGKSFT YSATLQIHER THTGEKPYEC SKCDKAFHSS SSYHRHERSH
MGEKPYQCKE CGKAFAYTSS LRRHERTHSG KKPYECKQYG EGLSYLISFQ THIRMNSGER
PYKCKICGKG FYSAKSFQTH EKTHTGEKRY KCKQCGKAFN LSSSFRYHER IHTGEKPYEC
KQCGKAFRSA SQLRVHGGTH TGEKPYECKE CGKAFRSTSH LRVHGRTHTG EKPYECKECG
KAFRYVKHLQ IHERTEKHIR MPSGERPYKC SICEKGFYSA KSFQTHEKTH TGEKPYECNQ
CGKAFRCCNS LRYHERTHTG EKPYECKQCG KAFRSASHLR MHERTHTGEK PYECKQCGKA
FSCASNLRKH GRTHTGEKPY ECKQCGKAFR SASNLQMHER THTGEKPYEC KECEKAFCKF
SSFQIHERKH RGEKPYECKH CGNGFTSAKI LQIHARTHIG EKHYECKECG KAFNYFSSLH
IHARTHMGEK PYECKDCGKA FS
