ZN701_HUMAN
ID ZN701_HUMAN Reviewed; 531 AA.
AC Q9NV72; A2RRM8; B9EGF2; F5GZM6; Q66K42;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2014, sequence version 3.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Zinc finger protein 701;
GN Name=ZNF701;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS PRO-70;
RP ILE-182; LYS-337 AND HIS-495.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP PRO-70; ILE-182 AND LYS-337.
RC TISSUE=Lymphoma, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-271, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NV72-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NV72-2; Sequence=VSP_055969;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK001753; BAA91884.1; -; mRNA.
DR EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC080612; AAH80612.2; -; mRNA.
DR EMBL; BC131719; AAI31720.1; -; mRNA.
DR EMBL; BC136425; AAI36426.1; -; mRNA.
DR EMBL; BC136426; AAI36427.1; -; mRNA.
DR CCDS; CCDS33092.1; -. [Q9NV72-2]
DR CCDS; CCDS54311.1; -. [Q9NV72-1]
DR RefSeq; NP_001166126.1; NM_001172655.1. [Q9NV72-1]
DR RefSeq; NP_060730.2; NM_018260.2. [Q9NV72-2]
DR RefSeq; XP_011525394.1; XM_011527092.1. [Q9NV72-1]
DR AlphaFoldDB; Q9NV72; -.
DR SMR; Q9NV72; -.
DR BioGRID; 120880; 5.
DR IntAct; Q9NV72; 3.
DR STRING; 9606.ENSP00000444339; -.
DR iPTMnet; Q9NV72; -.
DR PhosphoSitePlus; Q9NV72; -.
DR BioMuta; ZNF701; -.
DR DMDM; 296453055; -.
DR EPD; Q9NV72; -.
DR jPOST; Q9NV72; -.
DR MassIVE; Q9NV72; -.
DR MaxQB; Q9NV72; -.
DR PaxDb; Q9NV72; -.
DR PeptideAtlas; Q9NV72; -.
DR PRIDE; Q9NV72; -.
DR ProteomicsDB; 25076; -.
DR ProteomicsDB; 82756; -. [Q9NV72-1]
DR TopDownProteomics; Q9NV72-2; -. [Q9NV72-2]
DR Antibodypedia; 818; 100 antibodies from 16 providers.
DR DNASU; 55762; -.
DR Ensembl; ENST00000301093.6; ENSP00000301093.2; ENSG00000167562.14. [Q9NV72-1]
DR Ensembl; ENST00000391785.8; ENSP00000375662.2; ENSG00000167562.14. [Q9NV72-2]
DR Ensembl; ENST00000540331.1; ENSP00000444339.1; ENSG00000167562.14. [Q9NV72-1]
DR GeneID; 55762; -.
DR KEGG; hsa:55762; -.
DR MANE-Select; ENST00000391785.8; ENSP00000375662.2; NM_018260.3; NP_060730.2. [Q9NV72-2]
DR UCSC; uc002pzs.3; human. [Q9NV72-1]
DR CTD; 55762; -.
DR GeneCards; ZNF701; -.
DR HGNC; HGNC:25597; ZNF701.
DR HPA; ENSG00000167562; Low tissue specificity.
DR neXtProt; NX_Q9NV72; -.
DR OpenTargets; ENSG00000167562; -.
DR PharmGKB; PA142670498; -.
DR VEuPathDB; HostDB:ENSG00000167562; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154397; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; Q9NV72; -.
DR PhylomeDB; Q9NV72; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q9NV72; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9NV72; -.
DR BioGRID-ORCS; 55762; 9 hits in 1056 CRISPR screens.
DR ChiTaRS; ZNF701; human.
DR GenomeRNAi; 55762; -.
DR Pharos; Q9NV72; Tdark.
DR PRO; PR:Q9NV72; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NV72; protein.
DR Bgee; ENSG00000167562; Expressed in buccal mucosa cell and 123 other tissues.
DR ExpressionAtlas; Q9NV72; baseline and differential.
DR Genevisible; Q9NV72; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..531
FT /note="Zinc finger protein 701"
FT /id="PRO_0000233281"
FT DOMAIN 74..146
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 281..303
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..330
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..470
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 476..498
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 504..526
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 271
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..66
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_055969"
FT VARIANT 70
FT /note="L -> P (in dbSNP:rs162832)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_033592"
FT VARIANT 182
FT /note="T -> I (in dbSNP:rs366793)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_033593"
FT VARIANT 185
FT /note="L -> V (in dbSNP:rs12462687)"
FT /id="VAR_060432"
FT VARIANT 306
FT /note="D -> E (in dbSNP:rs427127)"
FT /id="VAR_061964"
FT VARIANT 337
FT /note="T -> K (in dbSNP:rs373554)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_052898"
FT VARIANT 495
FT /note="R -> H (in dbSNP:rs3745102)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_060433"
FT VARIANT 521
FT /note="R -> C (in dbSNP:rs444172)"
FT /id="VAR_033594"
SQ SEQUENCE 531 AA; 60903 MW; 0C93D18DC4B2BEBE CRC64;
MGFLHVGQDG LELPTSGDPP ASASQSAGIT GVSHRTQPPC FEGLTSKDLV REEKTRKRKR
KAKESGMALL QGLLTFRDVA IEFSQEEWKC LDPAQRTLYR DVMLENYRNL VSLDTSSKCM
MKMFSSTGQG NTEVVHTGTL QIHASHHIGD TCFQEIEKDI HDFVFQWQEN ETNGHEALMT
KTKKLMSSTE RHDQRHAGNK PIKNELGSSF HSHLPEVHIF HPEGKIGNQV EKAINDAFSV
SASQRISCRP KTRISNKYRN NFLQSSLLTQ KREVHTREKS FQRNESGKAF NGSSLLKKHQ
IIHLGDKQYK CDVCGKDFHQ KRYLACHRCH TGENPYTCNE CGKTFSHNSA LLVHKAIHTG
EKPYKCNECG KVFNQQSNLA RHHRVHTGEK PYKCEECDKV FSRKSHLERH RRIHTGEKPY
KCKVCDKAFR RDSHLAQHTV IHTGEKPYKC NECGKTFVQN SSLVMHKVIH TGEKRYKCNE
CGKVFNHKSN LACHRRLHTG EKPYKCNECG KVFNRKSNLE RHHRLHTGKK S
