ID   CCA22_ARATH             Reviewed;         436 AA.
AC   Q147G5; Q39073; Q9LFM7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Cyclin-A2-2;
DE   AltName: Full=Cyc3b-At;
DE   AltName: Full=Cyclin-3b;
DE   AltName: Full=G2/mitotic-specific cyclin-A2-2;
DE            Short=CycA2;2;
GN   Name=CYCA2-2; Synonyms=CYC3B; OrderedLocusNames=At5g11300;
GN   ORFNames=F2I11.190;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Columbia; TISSUE=Callus;
RX   PubMed=7972055; DOI=10.1073/pnas.91.24.11313;
RA   Ferreira P., Hemerly A., de Almeida Engler J., Bergounioux C., Burssens S.,
RA   van Montagu M., Engler G., Inze D.;
RT   "Three discrete classes of Arabidopsis cyclins are expressed during
RT   different intervals of the cell cycle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11313-11317(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15208425; DOI=10.1104/pp.104.040436;
RA   Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA   Ma H.;
RT   "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT   phylogenetic analysis of plant cyclin-like proteins.";
RL   Plant Physiol. 135:1084-1099(2004).
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers and
CC       siliques. {ECO:0000269|PubMed:7972055}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB96665.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; Z31402; CAA83277.1; -; mRNA.
DR   EMBL; AL360314; CAB96665.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED91657.1; -; Genomic_DNA.
DR   EMBL; BT026128; ABG48484.1; -; mRNA.
DR   RefSeq; NP_568248.2; NM_121168.5.
DR   AlphaFoldDB; Q147G5; -.
DR   SMR; Q147G5; -.
DR   BioGRID; 16279; 15.
DR   IntAct; Q147G5; 4.
DR   STRING; 3702.AT5G11300.1; -.
DR   PaxDb; Q147G5; -.
DR   PRIDE; Q147G5; -.
DR   EnsemblPlants; AT5G11300.1; AT5G11300.1; AT5G11300.
DR   GeneID; 831001; -.
DR   Gramene; AT5G11300.1; AT5G11300.1; AT5G11300.
DR   KEGG; ath:AT5G11300; -.
DR   Araport; AT5G11300; -.
DR   TAIR; locus:2148052; AT5G11300.
DR   eggNOG; KOG0654; Eukaryota.
DR   HOGENOM; CLU_020695_13_3_1; -.
DR   InParanoid; Q147G5; -.
DR   OMA; ELTLMEY; -.
DR   OrthoDB; 993640at2759; -.
DR   PhylomeDB; Q147G5; -.
DR   PRO; PR:Q147G5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q147G5; baseline and differential.
DR   Genevisible; Q147G5; AT.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:2000123; P:positive regulation of stomatal complex development; IGI:TAIR.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IGI:TAIR.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cyclin; Reference proteome.
FT   CHAIN           1..436
FT                   /note="Cyclin-A2-2"
FT                   /id="PRO_0000286994"
FT   CONFLICT        284
FT                   /note="P -> R (in Ref. 1; CAA83277)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        432
FT                   /note="S -> L (in Ref. 1; CAA83277)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   436 AA;  49694 MW;  E8971BD931AA25EF CRC64;
     MYCSSSMHPN ANKENISTSD VQESFVRITR SRAKKAMGRG VSIPPTKPSF KQQKRRAVLK
     DVSNTSADII YSELRKGGNI KANRKCLKEP KKAAKEGANS AMDILVDMHT EKSKLAEDLS
     KIRMAEAQDV SLSNFKDEEI TEQQEDGSGV MELLQVVDID SNVEDPQCCS LYAADIYDNI
     HVAELQQRPL ANYMELVQRD IDPDMRKILI DWLVEVSDDY KLVPDTLYLT VNLIDRFLSN
     SYIERQRLQL LGVSCMLIAS KYEELSAPGV EEFCFITANT YTRPEVLSME IQILNFVHFR
     LSVPTTKTFL RRFIKAAQAS YKVPFIELEY LANYLAELTL VEYSFLRFLP SLIAASAVFL
     ARWTLDQTDH PWNPTLQHYT RYEVAELKNT VLAMEDLQLN TSGCTLAATR EKYNQPKFKS
     VAKLTSPKRV TSLFSR