ZN703_MOUSE
ID ZN703_MOUSE Reviewed; 594 AA.
AC P0CL69;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Zinc finger protein 703;
DE AltName: Full=Zinc finger elbow-related proline domain protein 1;
GN Name=Znf703; Synonyms=Zeppo1, Zfp703, Zpo1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND INTERACTION WITH TLE4.
RX PubMed=21317240; DOI=10.1101/gad.1998111;
RA Slorach E.M., Chou J., Werb Z.;
RT "Zeppo1 is a novel metastasis promoter that represses E-cadherin expression
RT and regulates p120-catenin isoform expression and localization.";
RL Genes Dev. 25:471-484(2011).
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-584, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Transcriptional corepressor which does not bind directly to
CC DNA and may regulate transcription through recruitment of histone
CC deacetylases to gene promoters. Regulates cell adhesion, migration and
CC proliferation. May be required for segmental gene expression during
CC hindbrain development. {ECO:0000269|PubMed:21317240}.
CC -!- SUBUNIT: Interacts with DCAF7 and PHB2 (By similarity). Interacts with
CC TLE4; increases transcriptional repression. {ECO:0000250,
CC ECO:0000269|PubMed:21317240}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21317240}. Cytoplasm
CC {ECO:0000269|PubMed:21317240}.
CC -!- TISSUE SPECIFICITY: Expressed in mammary epithelium.
CC {ECO:0000269|PubMed:21317240}.
CC -!- DEVELOPMENTAL STAGE: Expressed in mammary placodes from 11.5 dpc onward
CC and in the developing intestinal epithelium.
CC {ECO:0000269|PubMed:21317240}.
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR EMBL; AC115820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52532.1; -.
DR RefSeq; NP_001094972.1; NM_001101502.1.
DR AlphaFoldDB; P0CL69; -.
DR STRING; 10090.ENSMUSP00000128757; -.
DR iPTMnet; P0CL69; -.
DR PhosphoSitePlus; P0CL69; -.
DR EPD; P0CL69; -.
DR MaxQB; P0CL69; -.
DR PaxDb; P0CL69; -.
DR PRIDE; P0CL69; -.
DR ProteomicsDB; 302140; -.
DR Antibodypedia; 10770; 306 antibodies from 32 providers.
DR Ensembl; ENSMUST00000154256; ENSMUSP00000128757; ENSMUSG00000085795.
DR GeneID; 353310; -.
DR KEGG; mmu:353310; -.
DR UCSC; uc012gbq.1; mouse.
DR CTD; 353310; -.
DR MGI; MGI:2662729; Zfp703.
DR VEuPathDB; HostDB:ENSMUSG00000085795; -.
DR eggNOG; ENOG502QV57; Eukaryota.
DR GeneTree; ENSGT00390000014618; -.
DR HOGENOM; CLU_035082_1_0_1; -.
DR InParanoid; P0CL69; -.
DR OMA; CKDPYCQ; -.
DR OrthoDB; 1163882at2759; -.
DR PhylomeDB; P0CL69; -.
DR TreeFam; TF324968; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 353310; 3 hits in 75 CRISPR screens.
DR PRO; PR:P0CL69; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P0CL69; protein.
DR Bgee; ENSMUSG00000085795; Expressed in prostate gland ventral lobe and 254 other tissues.
DR ExpressionAtlas; P0CL69; baseline and differential.
DR Genevisible; P0CL69; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016363; C:nuclear matrix; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034333; P:adherens junction assembly; IDA:UniProtKB.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IDA:UniProtKB.
DR GO; GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IDA:UniProtKB.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
DR InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12402; nlz1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Metal-binding; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H7S9"
FT CHAIN 2..594
FT /note="Zinc finger protein 703"
FT /id="PRO_0000407219"
FT ZN_FING 460..488
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H7S9"
FT MOD_RES 257
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H7S9"
FT MOD_RES 584
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 594 AA; 58730 MW; 4F87777F921DA6E9 CRC64;
MSDSPAGSNP RTPESSGSGG GSSSGGGGGK RPAVPAVVSL LPPADPLRQA NRLPIRVLKM
LSAHTGHLLH PEYLQPLSST PVSPIELDAK KSPLALLAQT CSQIGKPDPP PSSKLNSVAA
AAANGLGSEK DPSRSAPGAA SAAAALKQLG DSPAEDKSSF KPYSKGSGGG DSRKDSGSSS
VSSTTSSSSS SPGDKAGFRV PSAACPPFPP HGASVSTSSN SSSPGGSRGG SPHHSDCKNG
GGGAGELDKK EQEAKPSPEP AAGSRGSGGD SAHGGPEATA SGRKSEPPSA LVGAGHVAPV
SPYKPGHSVF PLPPSSIGYH GSIVGAYAGY PSQFVPGLDP SKSGLVGGQL SGGLGLPPGK
PPSSSPLTGA SPPSFLQGLC RDPYCLGGYH SASHLGGSSC STCSAHDPTG PSLKASGYPL
VYPGHPLQPA ALSSSAAQAA LPGHPLYTYG FMLQNEPLPH SCNWVAASGP CDKRFATSEE
LLSHLRTHTA LPGAEKLLAA YPGASSLGSA AAAAAAAASC HLHLPPPAAP GSPGSLSLRS
PHTLGLSRYH PYGKSHLSTA GGLAVPSLPT AGPYYSPYAL YGQRLASASA LGYQ
