ID   ZN703_XENTR             Reviewed;         537 AA.
AC   Q566L4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Zinc finger protein 703;
GN   Name=znf703;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional corepressor which does not bind directly to
CC       DNA and may regulate transcription through recruitment of histone
CC       deacetylases to gene promoters. Regulates cell adhesion, migration and
CC       proliferation (By similarity). Involved in specification of the lateral
CC       neural plate border (NPB) (By similarity). May be required for
CC       segmental gene expression during hindbrain development (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZWN6, ECO:0000250|UniProtKB:Q9H7S9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H7S9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9H7S9}.
CC   -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR   EMBL; BC093467; AAH93467.1; -; mRNA.
DR   RefSeq; NP_001025678.1; NM_001030507.1.
DR   AlphaFoldDB; Q566L4; -.
DR   PaxDb; Q566L4; -.
DR   DNASU; 595070; -.
DR   Ensembl; ENSXETT00000052626; ENSXETP00000052626; ENSXETG00000024347.
DR   GeneID; 595070; -.
DR   KEGG; xtr:595070; -.
DR   CTD; 80139; -.
DR   Xenbase; XB-GENE-1217460; znf703.
DR   eggNOG; ENOG502QV57; Eukaryota.
DR   HOGENOM; CLU_035082_1_0_1; -.
DR   InParanoid; Q566L4; -.
DR   OrthoDB; 1163882at2759; -.
DR   Reactome; R-XTR-212436; Generic Transcription Pathway.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024347; Expressed in neurula embryo and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016363; C:nuclear matrix; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034333; P:adherens junction assembly; ISS:UniProtKB.
DR   GO; GO:0034111; P:negative regulation of homotypic cell-cell adhesion; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF12402; nlz1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..537
FT                   /note="Zinc finger protein 703"
FT                   /id="PRO_0000292211"
FT   ZN_FING         409..437
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          90..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  55789 MW;  C01249CBB7EA2F3C CRC64;
     MNCSPPGSST DTERQSSSSG TPVAPRPTLA PTHPLRQANR LPIRLLKMLT AHTGHLLHPE
     YLQPLSSTPV SPIELDAKKS PLALLAQTCS QIGKPDPPPS SKLNSVTSSG LSEKESGRSS
     SLKLGESPLE DKSSFKPYSK GGESRKESGS SSGGAADKAG FRVPSGSCQP FPHAPSPSSR
     VSSPGQHCDS KNNESQEKKE PEANKANSET SQVNPTLTRA STSNSSAESS QSGDVTPISK
     ADPPSLGSGH VAPVSPYKPG HSVFPLPPSG IGYHGSIVGA YAGYPSQFVP GLDHTKTSLV
     GNQLPGTLGL PGKPPSSSPL TGASPPSFMQ GLCRDPYCLS YHNASHLGSS SCSTCVHDPS
     ALKSGYPLVY PSHPLHSVHT TLSSSVTPSL PGHPLYTYGF MLPNDPVPHI CNWVSASGPC
     DKRFSTSEEL LAHLRTHTAL PGADKLLAGY PTSTLGSAAS CHLHLPPAGP GSPNTLPGSL
     SLRSPHSLGL SRYHPYGKGH LTTPSGLPLP SLPAGSYYSP YALYGQRLTS ASALGYQ