ZN704_DANRE
ID ZN704_DANRE Reviewed; 501 AA.
AC Q1LY51;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Zinc finger protein 704;
GN Name=znf704; ORFNames=si:ch211-203l9.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Transcription factor. {ECO:0000250|UniProtKB:Q9ERQ3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ERQ3}.
CC -!- DOMAIN: The CR1 and CR2 motifs mediate sequence-specific DNA binding.
CC {ECO:0000250|UniProtKB:Q9ERQ3}.
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DR EMBL; BX119962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038383.2; NM_001044918.2.
DR AlphaFoldDB; Q1LY51; -.
DR SMR; Q1LY51; -.
DR STRING; 7955.ENSDARP00000082791; -.
DR PaxDb; Q1LY51; -.
DR Ensembl; ENSDART00000088358; ENSDARP00000082791; ENSDARG00000061718.
DR GeneID; 560056; -.
DR KEGG; dre:560056; -.
DR CTD; 619279; -.
DR ZFIN; ZDB-GENE-060503-775; znf704.
DR eggNOG; ENOG502QTDT; Eukaryota.
DR GeneTree; ENSGT00940000156172; -.
DR HOGENOM; CLU_032989_2_0_1; -.
DR InParanoid; Q1LY51; -.
DR OMA; RINSVVF; -.
DR OrthoDB; 915379at2759; -.
DR PhylomeDB; Q1LY51; -.
DR TreeFam; TF326610; -.
DR Reactome; R-DRE-212436; Generic Transcription Pathway.
DR PRO; PR:Q1LY51; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000061718; Expressed in retina and 15 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR031940; DUF4772.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF15997; DUF4772; 1.
DR SMART; SM00355; ZnF_C2H2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..501
FT /note="Zinc finger protein 704"
FT /id="PRO_0000288826"
FT ZN_FING 281..306
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 80..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 472..476
FT /note="CR1"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT MOTIF 490..494
FT /note="CR2"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT COMPBIAS 80..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 54294 MW; 10E81DE5DED32550 CRC64;
MHTRRLVKRS VIGSRVYAPG LTGDAAPLTG VIQAVKQDNR DASTGHRRNV YTVLMQDGSV
KEYSEEEIAQ MTAKAPLKSS LKSTCNGGQR DGLTQGQNGG VQRGEALSLS PESTEEPRVL
EHKRTGRALE TEKDHTRSVS LLEQKRKVVS SSIDVPQARK SEEEVDMDKV TAAMVLTSLS
TSPLVRSPPV KVSEGLNGSW KDGGFTPSSY SSSGYWSWSA PSDQSNPSTP SPPLSADSFK
PFRMPSLSGP PDDNIDEHDG NSLLFDEPIP RKRKNSMKVM FKCLWKNCGK VLSTAAGIQR
HIRTVHLGRN CDSECSDGEE DFYYTEIKLN TDSVADGLSS LSPVSPSVLS PPPALDQRQP
DGTNGTKSES SSSTPLSRSA PSALYLVHTD HAYQATTPVT IPSTSSTGFT PSSSSFSISW
QSPPVTFTGT SASPTHSRTQ GFGEQHSQTI AVLSSPPRAA GSLSRKSRGE GKKCRKVYGM
ENRDMWCTAC RWKKACQRFV D
