ZN704_HUMAN
ID ZN704_HUMAN Reviewed; 412 AA.
AC Q6ZNC4; B2RNE6; B9EGW6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Zinc finger protein 704;
GN Name=ZNF704;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: Transcription factor which binds to RE2 sequence elements in
CC the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}.
CC -!- INTERACTION:
CC Q6ZNC4; Q6P9E2: RECK; NbExp=3; IntAct=EBI-20866837, EBI-10253121;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ERQ3}.
CC -!- DOMAIN: The CR1 and CR2 motifs mediate sequence-specific DNA binding,
CC and are important for binding to the MYOD1 enhancer.
CC {ECO:0000250|UniProtKB:Q9ERQ3}.
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DR EMBL; AK131274; BAD18451.1; -; mRNA.
DR EMBL; BC136844; AAI36845.1; -; mRNA.
DR EMBL; BC136845; AAI36846.1; -; mRNA.
DR CCDS; CCDS34913.1; -.
DR RefSeq; NP_001028895.1; NM_001033723.2.
DR AlphaFoldDB; Q6ZNC4; -.
DR SMR; Q6ZNC4; -.
DR BioGRID; 534810; 27.
DR IntAct; Q6ZNC4; 19.
DR STRING; 9606.ENSP00000331462; -.
DR iPTMnet; Q6ZNC4; -.
DR PhosphoSitePlus; Q6ZNC4; -.
DR BioMuta; ZNF704; -.
DR DMDM; 74758726; -.
DR jPOST; Q6ZNC4; -.
DR MassIVE; Q6ZNC4; -.
DR PaxDb; Q6ZNC4; -.
DR PeptideAtlas; Q6ZNC4; -.
DR PRIDE; Q6ZNC4; -.
DR ProteomicsDB; 68011; -.
DR Antibodypedia; 12438; 53 antibodies from 12 providers.
DR DNASU; 619279; -.
DR Ensembl; ENST00000327835.7; ENSP00000331462.3; ENSG00000164684.13.
DR GeneID; 619279; -.
DR KEGG; hsa:619279; -.
DR MANE-Select; ENST00000327835.7; ENSP00000331462.3; NM_001033723.3; NP_001028895.1.
DR UCSC; uc003yby.2; human.
DR CTD; 619279; -.
DR DisGeNET; 619279; -.
DR GeneCards; ZNF704; -.
DR HGNC; HGNC:32291; ZNF704.
DR HPA; ENSG00000164684; Low tissue specificity.
DR neXtProt; NX_Q6ZNC4; -.
DR OpenTargets; ENSG00000164684; -.
DR PharmGKB; PA142670501; -.
DR VEuPathDB; HostDB:ENSG00000164684; -.
DR eggNOG; ENOG502QTDT; Eukaryota.
DR GeneTree; ENSGT00940000156172; -.
DR HOGENOM; CLU_032989_1_1_1; -.
DR InParanoid; Q6ZNC4; -.
DR OMA; RINSVVF; -.
DR OrthoDB; 915379at2759; -.
DR PhylomeDB; Q6ZNC4; -.
DR TreeFam; TF326610; -.
DR PathwayCommons; Q6ZNC4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZNC4; -.
DR BioGRID-ORCS; 619279; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; ZNF704; human.
DR GenomeRNAi; 619279; -.
DR Pharos; Q6ZNC4; Tdark.
DR PRO; PR:Q6ZNC4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6ZNC4; protein.
DR Bgee; ENSG00000164684; Expressed in epithelial cell of pancreas and 190 other tissues.
DR ExpressionAtlas; Q6ZNC4; baseline and differential.
DR Genevisible; Q6ZNC4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..412
FT /note="Zinc finger protein 704"
FT /id="PRO_0000288824"
FT ZN_FING 193..218
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 98..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..412
FT /note="Sufficient for binding to RE2 sequence motifs"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT REGION 351..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 383..387
FT /note="CR1"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT MOTIF 401..405
FT /note="CR2"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT COMPBIAS 117..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT MOD_RES 228
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9ERQ3"
FT VARIANT 35
FT /note="A -> S (in dbSNP:rs3907424)"
FT /id="VAR_032506"
SQ SEQUENCE 412 AA; 45276 MW; 3093527F3415E748 CRC64;
MTFTFQSEDL KRDCGKKMSH QHVFSLAMEE DVKTADTKKA SRILDHEKEN TRSICLLEQK
RKVVSSNIDV PPARKSSEEL DMDKVTAAMV LTSLSTSPLV RSPPVRPNES LSGSWKEGGC
VPSSTSSSGY WSWSAPSDQS NPSTPSPPLS ADSFKPFRSP AQPDDGIDEA EASNLLFDEP
IPRKRKNSMK VMFKCLWKNC GKVLSTAAGI QKHIRTIHLG RVGDSDYSDG EEDFYYTEIK
LNTDSVADGL SSLAPVSPSQ SLASPPTFPI PDSSRTETPC AKTETKLMTP LSRSAPTTLY
LVHTDHAYQA TPPVTIPGSA KFTPNGSSFS ISWQSPPVTF TGIPVSPTHH PVGTGEQRQH
AHTVLSSPPR GTVSLRKPRG EGKKCRKVYG MENRDMWCTA CRWKKACQRF LD
