ZN706_HUMAN
ID ZN706_HUMAN Reviewed; 76 AA.
AC Q9Y5V0; A8K362;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Zinc finger protein 706 {ECO:0000305};
GN Name=ZNF706 {ECO:0000312|HGNC:HGNC:24992}; ORFNames=HSPC038, PNAS-113;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Promyelocytic leukemia;
RA Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W.,
RA Yang H., Zhao Z.-L.;
RT "Human acute promyelocytic leukemia cell line NB4's apoptosis related
RT genes.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Transcription repressor involved in the exit of embryonic
CC stem cells (ESCs) from self-renewal. Acts by repressing expression of
CC KLF4. {ECO:0000250|UniProtKB:Q9D115}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D115}. Nucleus
CC {ECO:0000250|UniProtKB:Q9D115}.
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DR EMBL; AF125099; AAD39916.1; -; mRNA.
DR EMBL; AF275809; AAG23820.1; -; mRNA.
DR EMBL; AK290477; BAF83166.1; -; mRNA.
DR EMBL; CH471060; EAW91831.1; -; Genomic_DNA.
DR EMBL; BC015925; AAH15925.1; -; mRNA.
DR EMBL; BC068524; AAH68524.1; -; mRNA.
DR CCDS; CCDS6291.1; -.
DR RefSeq; NP_001035975.1; NM_001042510.1.
DR RefSeq; NP_001254637.1; NM_001267708.1.
DR RefSeq; NP_001254638.1; NM_001267709.1.
DR RefSeq; NP_057180.1; NM_016096.3.
DR AlphaFoldDB; Q9Y5V0; -.
DR BioGRID; 119310; 8.
DR IntAct; Q9Y5V0; 2.
DR STRING; 9606.ENSP00000430823; -.
DR iPTMnet; Q9Y5V0; -.
DR PhosphoSitePlus; Q9Y5V0; -.
DR BioMuta; ZNF706; -.
DR DMDM; 74735296; -.
DR EPD; Q9Y5V0; -.
DR jPOST; Q9Y5V0; -.
DR MassIVE; Q9Y5V0; -.
DR MaxQB; Q9Y5V0; -.
DR PaxDb; Q9Y5V0; -.
DR PeptideAtlas; Q9Y5V0; -.
DR PRIDE; Q9Y5V0; -.
DR ProteomicsDB; 86513; -.
DR TopDownProteomics; Q9Y5V0; -.
DR Antibodypedia; 26241; 36 antibodies from 13 providers.
DR DNASU; 51123; -.
DR Ensembl; ENST00000311212.9; ENSP00000311768.4; ENSG00000120963.12.
DR Ensembl; ENST00000517844.5; ENSP00000428227.1; ENSG00000120963.12.
DR Ensembl; ENST00000518336.5; ENSP00000428696.1; ENSG00000120963.12.
DR Ensembl; ENST00000519882.5; ENSP00000428985.1; ENSG00000120963.12.
DR Ensembl; ENST00000520347.5; ENSP00000430823.1; ENSG00000120963.12.
DR Ensembl; ENST00000520984.5; ENSP00000427761.1; ENSG00000120963.12.
DR Ensembl; ENST00000521272.5; ENSP00000430165.1; ENSG00000120963.12.
DR GeneID; 51123; -.
DR KEGG; hsa:51123; -.
DR MANE-Select; ENST00000311212.9; ENSP00000311768.4; NM_016096.5; NP_057180.1.
DR UCSC; uc003yka.4; human.
DR CTD; 51123; -.
DR GeneCards; ZNF706; -.
DR HGNC; HGNC:24992; ZNF706.
DR HPA; ENSG00000120963; Low tissue specificity.
DR MIM; 619526; gene.
DR neXtProt; NX_Q9Y5V0; -.
DR OpenTargets; ENSG00000120963; -.
DR PharmGKB; PA142670505; -.
DR VEuPathDB; HostDB:ENSG00000120963; -.
DR eggNOG; KOG4118; Eukaryota.
DR GeneTree; ENSGT00390000003465; -.
DR HOGENOM; CLU_176397_0_0_1; -.
DR InParanoid; Q9Y5V0; -.
DR OMA; EAKHPKD; -.
DR OrthoDB; 1620202at2759; -.
DR PhylomeDB; Q9Y5V0; -.
DR TreeFam; TF315171; -.
DR PathwayCommons; Q9Y5V0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9Y5V0; -.
DR BioGRID-ORCS; 51123; 35 hits in 1055 CRISPR screens.
DR ChiTaRS; ZNF706; human.
DR GenomeRNAi; 51123; -.
DR Pharos; Q9Y5V0; Tdark.
DR PRO; PR:Q9Y5V0; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9Y5V0; protein.
DR Bgee; ENSG00000120963; Expressed in body of pancreas and 175 other tissues.
DR ExpressionAtlas; Q9Y5V0; baseline and differential.
DR Genevisible; Q9Y5V0; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1902455; P:negative regulation of stem cell population maintenance; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1050.10; -; 1.
DR InterPro; IPR045230; MBS1/2-like.
DR InterPro; IPR007513; Uncharacterised_SERF_N.
DR InterPro; IPR026939; ZNF706/At2g23090_sf.
DR PANTHER; PTHR21213; PTHR21213; 1.
DR Pfam; PF04419; 4F5; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repressor;
KW Translation regulation; Zinc; Zinc-finger.
FT CHAIN 1..76
FT /note="Zinc finger protein 706"
FT /id="PRO_0000047703"
FT ZN_FING 39..62
FT /note="C2H2-type"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 8498 MW; 3EDEABD9FFE529FF CRC64;
MARGQQKIQS QQKNAKKQAG QKKKQGHDQK AAAKAALIYT CTVCRTQMPD PKTFKQHFES
KHPKTPLPPE LADVQA
