ZN706_MOUSE
ID ZN706_MOUSE Reviewed; 76 AA.
AC Q9D115;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc finger protein 706 {ECO:0000305};
GN Name=Znf706 {ECO:0000250|UniProtKB:Q9Y5V0};
GN Synonyms=Zfp706 {ECO:0000312|MGI:MGI:1915286};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=BALB/cJ, C57BL/6J, and DBA/2J;
RC TISSUE=Cerebellum, Head, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP 41-CYS--CYS-44.
RX PubMed=24412312; DOI=10.1016/j.stem.2013.12.008;
RA Leeb M., Dietmann S., Paramor M., Niwa H., Smith A.;
RT "Genetic exploration of the exit from self-renewal using haploid embryonic
RT stem cells.";
RL Cell Stem Cell 14:385-393(2014).
CC -!- FUNCTION: Transcription repressor involved in the exit of embryonic
CC stem cells (ESCs) from self-renewal. Acts by repressing expression of
CC KLF4. {ECO:0000269|PubMed:24412312}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24412312}. Nucleus
CC {ECO:0000269|PubMed:24412312}.
CC -!- DEVELOPMENTAL STAGE: Present in self-renewing embryonic stem cells
CC (ESCs). Does not increase significantly at the onset of
CC differentiation. {ECO:0000269|PubMed:24412312}.
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DR EMBL; AK004076; BAB23156.1; -; mRNA.
DR EMBL; AK032231; BAC27773.1; -; mRNA.
DR EMBL; AK082392; BAC38485.1; -; mRNA.
DR EMBL; AK132053; BAE20963.1; -; mRNA.
DR EMBL; AK145319; BAE26365.1; -; mRNA.
DR EMBL; AK166530; BAE38834.1; -; mRNA.
DR EMBL; AK167791; BAE39821.1; -; mRNA.
DR EMBL; AK167897; BAE39908.1; -; mRNA.
DR EMBL; AK168303; BAE40244.1; -; mRNA.
DR EMBL; AK168958; BAE40764.1; -; mRNA.
DR EMBL; BC037600; AAH37600.1; -; mRNA.
DR EMBL; BC042704; AAH42704.1; -; mRNA.
DR EMBL; BC052459; AAH52459.1; -; mRNA.
DR EMBL; BC085477; AAH85477.1; -; mRNA.
DR CCDS; CCDS37063.1; -.
DR RefSeq; NP_080797.1; NM_026521.4.
DR AlphaFoldDB; Q9D115; -.
DR IntAct; Q9D115; 2.
DR MINT; Q9D115; -.
DR STRING; 10090.ENSMUSP00000077996; -.
DR iPTMnet; Q9D115; -.
DR PhosphoSitePlus; Q9D115; -.
DR EPD; Q9D115; -.
DR MaxQB; Q9D115; -.
DR PaxDb; Q9D115; -.
DR PRIDE; Q9D115; -.
DR ProteomicsDB; 302141; -.
DR Antibodypedia; 26241; 36 antibodies from 13 providers.
DR DNASU; 68036; -.
DR Ensembl; ENSMUST00000078976; ENSMUSP00000077996; ENSMUSG00000062397.
DR Ensembl; ENSMUST00000226453; ENSMUSP00000154190; ENSMUSG00000062397.
DR Ensembl; ENSMUST00000226671; ENSMUSP00000154192; ENSMUSG00000062397.
DR Ensembl; ENSMUST00000228275; ENSMUSP00000154243; ENSMUSG00000062397.
DR GeneID; 68036; -.
DR KEGG; mmu:68036; -.
DR UCSC; uc007vnb.1; mouse.
DR CTD; 68036; -.
DR MGI; MGI:1915286; Zfp706.
DR VEuPathDB; HostDB:ENSMUSG00000062397; -.
DR eggNOG; KOG4118; Eukaryota.
DR GeneTree; ENSGT00390000003465; -.
DR HOGENOM; CLU_176397_0_0_1; -.
DR InParanoid; Q9D115; -.
DR OMA; EAKHPKD; -.
DR OrthoDB; 1620202at2759; -.
DR PhylomeDB; Q9D115; -.
DR TreeFam; TF315171; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 68036; 7 hits in 70 CRISPR screens.
DR ChiTaRS; Zfp706; mouse.
DR PRO; PR:Q9D115; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D115; protein.
DR Bgee; ENSMUSG00000062397; Expressed in vestibular membrane of cochlear duct and 263 other tissues.
DR ExpressionAtlas; Q9D115; baseline and differential.
DR Genevisible; Q9D115; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1902455; P:negative regulation of stem cell population maintenance; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1050.10; -; 1.
DR InterPro; IPR045230; MBS1/2-like.
DR InterPro; IPR007513; Uncharacterised_SERF_N.
DR InterPro; IPR026939; ZNF706/At2g23090_sf.
DR PANTHER; PTHR21213; PTHR21213; 1.
DR Pfam; PF04419; 4F5; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repressor;
KW Translation regulation; Zinc; Zinc-finger.
FT CHAIN 1..76
FT /note="Zinc finger protein 706"
FT /id="PRO_0000047704"
FT ZN_FING 39..62
FT /note="C2H2-type"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 41..44
FT /note="CTVC->ATVA: Unable to restore differentiation of
FT embryonic stem cells (ESCs)."
FT /evidence="ECO:0000269|PubMed:24412312"
SQ SEQUENCE 76 AA; 8498 MW; 3EDEABD9FFE529FF CRC64;
MARGQQKIQS QQKNAKKQAG QKKKQGHDQK AAAKAALIYT CTVCRTQMPD PKTFKQHFES
KHPKTPLPPE LADVQA
