CCA23_ARATH
ID CCA23_ARATH Reviewed; 450 AA.
AC Q38819; Q8VYG1; Q9M9D7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 146.
DE RecName: Full=Cyclin-A2-3;
DE AltName: Full=Cyc3c-At;
DE AltName: Full=Cyclin-3c;
DE AltName: Full=G2/mitotic-specific cyclin-A2-3;
DE Short=CycA2;3;
GN Name=CYCA2-3; Synonyms=CYC3C; OrderedLocusNames=At1g15570;
GN ORFNames=T16N11.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 224-450.
RC STRAIN=cv. Columbia;
RA Lu G., Ferl R.J.;
RT "An Arabidopsis cDNA clone encoding cyclin.";
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CDKA-1.
RX PubMed=16415207; DOI=10.1105/tpc.105.037309;
RA Imai K.K., Ohashi Y., Tsuge T., Yoshizumi T., Matsui M., Oka A., Aoyama T.;
RT "The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in
RT Arabidopsis endoreduplication.";
RL Plant Cell 18:382-396(2006).
RN [7]
RP REGULATION BY MYB88 AND MYB124.
RX PubMed=21772250; DOI=10.1038/emboj.2011.240;
RA Vanneste S., Coppens F., Lee E., Donner T.J., Xie Z., Van Isterdael G.,
RA Dhondt S., De Winter F., De Rybel B., Vuylsteke M., De Veylder L.,
RA Friml J., Inze D., Grotewold E., Scarpella E., Sack F., Beemster G.T.,
RA Beeckman T.;
RT "Developmental regulation of CYCA2s contributes to tissue-specific
RT proliferation in Arabidopsis.";
RL EMBO J. 30:3430-3441(2011).
RN [8]
RP INTERACTION WITH SAMBA.
RX PubMed=22869741; DOI=10.1073/pnas.1211418109;
RA Eloy N.B., Gonzalez N., Van Leene J., Maleux K., Vanhaeren H., De Milde L.,
RA Dhondt S., Vercruysse L., Witters E., Mercier R., Cromer L., Beemster G.T.,
RA Remaut H., Van Montagu M.C., De Jaeger G., Ferreira P.C., Inze D.;
RT "SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is
RT involved in early development and A-type cyclin stabilization.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:13853-13858(2012).
RN [9]
RP FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=24687979; DOI=10.1093/jxb/eru139;
RA Yang K., Wang H., Xue S., Qu X., Zou J., Le J.;
RT "Requirement for A-type cyclin-dependent kinase and cyclins for the
RT terminal division in the stomatal lineage of Arabidopsis.";
RL J. Exp. Bot. 65:2449-2461(2014).
CC -!- FUNCTION: Negatively regulates endocycles and acts as a regulator of
CC ploidy levels in endoreduplication (PubMed:16415207). Promotes
CC divisions in the guard cells (GCs) after the guard mother cells (GMC)
CC symmetric division (PubMed:24687979). {ECO:0000269|PubMed:16415207,
CC ECO:0000269|PubMed:24687979}.
CC -!- SUBUNIT: Interacts with CDKA-1 (PubMed:16415207). Interacts with SAMBA
CC (PubMed:22869741). {ECO:0000269|PubMed:16415207,
CC ECO:0000269|PubMed:22869741}.
CC -!- INTERACTION:
CC Q38819; A0A384L704: At3g12720; NbExp=3; IntAct=EBI-1781564, EBI-25519283;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16415207}.
CC -!- INDUCTION: Repressed by MYB88 and MYB124 in newly formed guard cells.
CC {ECO:0000269|PubMed:21772250}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF71982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC013453; AAF71982.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29336.1; -; Genomic_DNA.
DR EMBL; AY072105; AAL59927.1; -; mRNA.
DR EMBL; AY096733; AAM20367.1; -; mRNA.
DR EMBL; U17890; AAA90946.1; -; mRNA.
DR PIR; F86289; F86289.
DR PIR; S71193; S71193.
DR RefSeq; NP_173010.1; NM_101426.5.
DR AlphaFoldDB; Q38819; -.
DR SMR; Q38819; -.
DR BioGRID; 23367; 32.
DR IntAct; Q38819; 26.
DR STRING; 3702.AT1G15570.1; -.
DR PaxDb; Q38819; -.
DR PRIDE; Q38819; -.
DR EnsemblPlants; AT1G15570.1; AT1G15570.1; AT1G15570.
DR GeneID; 838127; -.
DR Gramene; AT1G15570.1; AT1G15570.1; AT1G15570.
DR KEGG; ath:AT1G15570; -.
DR Araport; AT1G15570; -.
DR TAIR; locus:2196563; AT1G15570.
DR eggNOG; KOG0654; Eukaryota.
DR HOGENOM; CLU_020695_13_3_1; -.
DR InParanoid; Q38819; -.
DR OMA; AKWTMDQ; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; Q38819; -.
DR PRO; PR:Q38819; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q38819; baseline and differential.
DR Genevisible; Q38819; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044839; P:cell cycle G2/M phase transition; IGI:TAIR.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0042023; P:DNA endoreduplication; IMP:TAIR.
DR GO; GO:0010444; P:guard mother cell differentiation; IMP:UniProtKB.
DR GO; GO:0010311; P:lateral root formation; IGI:TAIR.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:2000123; P:positive regulation of stomatal complex development; IGI:TAIR.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IGI:TAIR.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Nucleus; Reference proteome.
FT CHAIN 1..450
FT /note="Cyclin-A2-3"
FT /id="PRO_0000286995"
FT REGION 18..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 299
FT /note="R -> E (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="F -> S (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="E -> G (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="T -> A (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="Y -> C (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="N -> T (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="E -> D (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="A -> P (in Ref. 4; AAA90946)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 450 AA; 50642 MW; 8EF3B638843CD478 CRC64;
MGKENAVSRP FTRSLASALR ASEVTSTTQN QQRVNTKRPA LEDTRATGPN KRKKRAVLGE
ITNVNSNTAI LEAKNSKQIK KGRGHGLAST SQLATSVTSE VTDLQSRTDA KVEVASNTAG
NLSVSKGTDN TADNCIEIWN SRLPPRPLGR SASTAEKSAV IGSSTVPDIP KFVDIDSDDK
DPLLCCLYAP EIHYNLRVSE LKRRPLPDFM ERIQKDVTQS MRGILVDWLV EVSEEYTLAS
DTLYLTVYLI DWFLHGNYVQ RQQLQLLGIT CMLIASKYEE ISAPRIEEFC FITDNTYTRD
QVLEMENQVL KHFSFQIYTP TPKTFLRRFL RAAQASRLSP SLEVEFLASY LTELTLIDYH
FLKFLPSVVA ASAVFLAKWT MDQSNHPWNP TLEHYTTYKA SDLKASVHAL QDLQLNTKGC
PLSAIRMKYR QEKYKSVAVL TSPKLLDTLF
