ZN707_HUMAN
ID ZN707_HUMAN Reviewed; 371 AA.
AC Q96C28; A8K317; B3KNY1; D3DWK7;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 707;
GN Name=ZNF707;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT HIS-96.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-96.
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-144, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96C28; Q6NVI2: CASP8; NbExp=3; IntAct=EBI-748111, EBI-12861768;
CC Q96C28; O95273: CCNDBP1; NbExp=7; IntAct=EBI-748111, EBI-748961;
CC Q96C28; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-748111, EBI-10172150;
CC Q96C28; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-748111, EBI-10172290;
CC Q96C28; Q99750: MDFI; NbExp=5; IntAct=EBI-748111, EBI-724076;
CC Q96C28; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-748111, EBI-928842;
CC Q96C28; Q15311: RALBP1; NbExp=6; IntAct=EBI-748111, EBI-749285;
CC Q96C28; Q16623: STX1A; NbExp=3; IntAct=EBI-748111, EBI-712466;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH14894.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAF83121.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK290432; BAF83121.1; ALT_INIT; mRNA.
DR EMBL; AK055263; BAG51493.1; -; mRNA.
DR EMBL; AC105219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471162; EAW82210.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82211.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82214.1; -; Genomic_DNA.
DR EMBL; BC014894; AAH14894.1; ALT_INIT; mRNA.
DR CCDS; CCDS47932.1; -.
DR RefSeq; NP_001094068.1; NM_001100598.1.
DR RefSeq; NP_001094069.1; NM_001100599.1.
DR RefSeq; NP_001275734.1; NM_001288805.1.
DR RefSeq; NP_001275735.1; NM_001288806.1.
DR RefSeq; NP_001275736.1; NM_001288807.1.
DR RefSeq; NP_001275737.1; NM_001288808.1.
DR RefSeq; NP_001275738.1; NM_001288809.1.
DR RefSeq; NP_776192.2; NM_173831.3.
DR RefSeq; XP_011515279.1; XM_011516977.2.
DR AlphaFoldDB; Q96C28; -.
DR SMR; Q96C28; -.
DR BioGRID; 130290; 80.
DR IntAct; Q96C28; 45.
DR STRING; 9606.ENSP00000436212; -.
DR iPTMnet; Q96C28; -.
DR PhosphoSitePlus; Q96C28; -.
DR BioMuta; ZNF707; -.
DR DMDM; 296453056; -.
DR EPD; Q96C28; -.
DR MassIVE; Q96C28; -.
DR PaxDb; Q96C28; -.
DR PeptideAtlas; Q96C28; -.
DR PRIDE; Q96C28; -.
DR Antibodypedia; 7422; 97 antibodies from 22 providers.
DR DNASU; 286075; -.
DR Ensembl; ENST00000358656.9; ENSP00000351482.4; ENSG00000181135.16.
DR Ensembl; ENST00000418203.3; ENSP00000413215.2; ENSG00000181135.16.
DR Ensembl; ENST00000532158.5; ENSP00000436250.1; ENSG00000181135.16.
DR Ensembl; ENST00000532205.5; ENSP00000436212.1; ENSG00000181135.16.
DR Ensembl; ENST00000611146.4; ENSP00000484032.2; ENSG00000274352.4.
DR Ensembl; ENST00000611844.4; ENSP00000481069.1; ENSG00000274352.4.
DR Ensembl; ENST00000617261.4; ENSP00000484744.2; ENSG00000274352.4.
DR Ensembl; ENST00000622212.1; ENSP00000481033.1; ENSG00000274352.4.
DR GeneID; 286075; -.
DR KEGG; hsa:286075; -.
DR MANE-Select; ENST00000358656.9; ENSP00000351482.4; NM_001100598.2; NP_001094068.1.
DR UCSC; uc003yze.5; human.
DR CTD; 286075; -.
DR GeneCards; ZNF707; -.
DR HGNC; HGNC:27815; ZNF707.
DR HPA; ENSG00000181135; Low tissue specificity.
DR neXtProt; NX_Q96C28; -.
DR OpenTargets; ENSG00000181135; -.
DR PharmGKB; PA142670506; -.
DR VEuPathDB; HostDB:ENSG00000181135; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164666; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q96C28; -.
DR OMA; EPWVEDW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96C28; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q96C28; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96C28; -.
DR BioGRID-ORCS; 286075; 12 hits in 1099 CRISPR screens.
DR GenomeRNAi; 286075; -.
DR Pharos; Q96C28; Tdark.
DR PRO; PR:Q96C28; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96C28; protein.
DR Bgee; ENSG00000181135; Expressed in right testis and 97 other tissues.
DR ExpressionAtlas; Q96C28; baseline and differential.
DR Genevisible; Q96C28; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..371
FT /note="Zinc finger protein 707"
FT /id="PRO_0000233284"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 176..198
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 71..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 144
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 96
FT /note="P -> H (in dbSNP:rs6987308)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_033596"
FT CONFLICT 26
FT /note="E -> V (in Ref. 1; BAF83121)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="L -> F (in Ref. 1; BAG51493)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 43088 MW; 113B680E5296FF3B CRC64;
MDMAQEPVTF RDVAIYFSRE EWACLEPSQR ALYRDVMLDN FSSVAALGFC SPRPDLVSRL
EQWEEPWVED RERPEFQAVQ RGPRPGARKS ADPKRPCDHP AWAHKKTHVR RERAREGSSF
RKGFRLDTDD GQLPRAAPER TDAKPTAFPC QVLTQRCGRR PGRRERRKQR AVELSFICGT
CGKALSCHSR LLAHQTVHTG TKAFECPECG QTFRWASNLQ RHQKNHTREK PFCCEACGQA
FSLKDRLAQH RKVHTEHRPY SCGDCGKAFK QKSNLLRHQL VHTGERPFYC ADCGKAFRTK
ENLSHHQRVH SGEKPYTCAE CGKSFRWPKG FSIHRRLHLT KRFYECGHCG KGFRHLGFFT
RHQRTHRHGE V
